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Sex Hormone-Binding Globulin Deficiency

MedGen UID:
887851
•Concept ID:
C4054031
•
Finding

Definition

Subnormal concentration of the glycoprotein, sex hormone-binding globulin (SHBG), the primary transport protein for androgens and estrogens in serum, resulting in reduced concentrations of total sex steroids, but minimal change in concentrations of free sex steroids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Sex Hormone-Binding Globulin Deficiency

Professional guidelines

PubMed

EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA
J Clin Endocrinol Metab 2018 May 1;103(5):1715-1744. doi: 10.1210/jc.2018-00229. PMID: 29562364
Treatment with statins and testosterone levels in men.
Mędraś M, Kubicka E, Jóźkow P, Słowińska-Lisowska M, Trzmiel-Bira A, Filus A
Endokrynol Pol 2014;65(6):464-8. doi: 10.5603/EP.2014.0064. PMID: 25554614

Recent clinical studies

Etiology

Low circulating androgens and mortality risk in heart failure.
Güder G, Frantz S, Bauersachs J, Allolio B, Ertl G, Angermann CE, Störk S
Heart 2010 Apr;96(7):504-9. Epub 2009 Oct 28 doi: 10.1136/hrt.2009.181065. PMID: 19875366
Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age.
Ibáñez L, Lopez-Bermejo A, Díaz M, Suárez L, de Zegher F
J Clin Endocrinol Metab 2009 Oct;94(10):3696-9. Epub 2009 Sep 8 doi: 10.1210/jc.2009-0789. PMID: 19737922
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
Starka L, Duskova M, Cermakova I, Vrbiková J, Hill M
Endocr Regul 2005 Dec;39(4):127-31. PMID: 16552990
Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic beta-cell demand in men.
Reis AF, Miranda WL, Chacra AR
Braz J Med Biol Res 1998 Dec;31(12):1545-51. doi: 10.1590/s0100-879x1998001200006. PMID: 9951550
Characterization of obese women with reduced sex hormone-binding globulin concentrations.
Pasquali R, Casimirri F, Platè L, Capelli M
Horm Metab Res 1990 May;22(5):303-6. doi: 10.1055/s-2007-1004907. PMID: 2189819

Diagnosis

Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
Starka L, Duskova M, Cermakova I, Vrbiková J, Hill M
Endocr Regul 2005 Dec;39(4):127-31. PMID: 16552990

Therapy

Sex hormone binding globulin decrease as a potential pathogenetic factor for hirsutism in adolescent girls.
Cross G, Danilowicz K, Kral M, Caufriez A, Copinschi G, Bruno OD
Medicina (B Aires) 2008;68(2):120-4. PMID: 18499959
Hypergonadotropic hypogonadism, SHBG deficiency and hyperprolactinaemia: a transient phenomenon during induction chemotherapy in leukemic children.
Beck W, Schwarz S, Heidemann PH, Jentsch E, Stubbe P, König A
Eur J Pediatr 1982 May;138(3):216-20. doi: 10.1007/BF00441205. PMID: 6811275

Prognosis

Sex hormone binding globulin deficiency due to a homozygous missense mutation.
Vos MJ, Mijnhout GS, Rondeel JM, Baron W, Groeneveld PH
J Clin Endocrinol Metab 2014 Sep;99(9):E1798-802. Epub 2014 Jun 17 doi: 10.1210/jc.2014-2055. PMID: 24937543
Low circulating androgens and mortality risk in heart failure.
Güder G, Frantz S, Bauersachs J, Allolio B, Ertl G, Angermann CE, Störk S
Heart 2010 Apr;96(7):504-9. Epub 2009 Oct 28 doi: 10.1136/hrt.2009.181065. PMID: 19875366
Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age.
Ibáñez L, Lopez-Bermejo A, Díaz M, Suárez L, de Zegher F
J Clin Endocrinol Metab 2009 Oct;94(10):3696-9. Epub 2009 Sep 8 doi: 10.1210/jc.2009-0789. PMID: 19737922
Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic beta-cell demand in men.
Reis AF, Miranda WL, Chacra AR
Braz J Med Biol Res 1998 Dec;31(12):1545-51. doi: 10.1590/s0100-879x1998001200006. PMID: 9951550

Clinical prediction guides

Sex hormone binding globulin deficiency due to a homozygous missense mutation.
Vos MJ, Mijnhout GS, Rondeel JM, Baron W, Groeneveld PH
J Clin Endocrinol Metab 2014 Sep;99(9):E1798-802. Epub 2014 Jun 17 doi: 10.1210/jc.2014-2055. PMID: 24937543
Low circulating androgens and mortality risk in heart failure.
Güder G, Frantz S, Bauersachs J, Allolio B, Ertl G, Angermann CE, Störk S
Heart 2010 Apr;96(7):504-9. Epub 2009 Oct 28 doi: 10.1136/hrt.2009.181065. PMID: 19875366
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome?
Starka L, Duskova M, Cermakova I, Vrbiková J, Hill M
Endocr Regul 2005 Dec;39(4):127-31. PMID: 16552990
Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic beta-cell demand in men.
Reis AF, Miranda WL, Chacra AR
Braz J Med Biol Res 1998 Dec;31(12):1545-51. doi: 10.1590/s0100-879x1998001200006. PMID: 9951550
Characterization of obese women with reduced sex hormone-binding globulin concentrations.
Pasquali R, Casimirri F, Platè L, Capelli M
Horm Metab Res 1990 May;22(5):303-6. doi: 10.1055/s-2007-1004907. PMID: 2189819

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    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations

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