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Abnormality of connective tissue

MedGen UID:
871127
Concept ID:
C4025596
Anatomical Abnormality
HPO: HP:0003549

Definition

Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of connective tissue

Professional guidelines

PubMed

Mokri B
Curr Opin Neurol 2003 Jun;16(3):319-26. doi: 10.1097/01.wco.0000073933.19076.c0. PMID: 12858068
Perloff JK, Child JS, Edwards JE
Am J Cardiol 1986 May 1;57(13):1124-9. doi: 10.1016/0002-9149(86)90686-7. PMID: 3706164

Recent clinical studies

Etiology

Alsiri N, Alhadhoud M, Alkatefi T, Palmer S
Semin Arthritis Rheum 2023 Feb;58:152127. Epub 2022 Nov 17 doi: 10.1016/j.semarthrit.2022.152127. PMID: 36462303
Saeidian AH, Youssefian L, Huang J, Touati A, Vahidnezhad H, Kowal L, Caffet M, Wurst T, Singh J, Snook AE, Ryu E, Fortina P, Terry SF, Schoenecker JG, Uitto J, Li Q
Genet Med 2022 Jan;24(1):75-86. Epub 2021 Nov 30 doi: 10.1016/j.gim.2021.08.011. PMID: 34906475Free PMC Article
Malfait F, Wenstrup RJ, De Paepe A
Genet Med 2010 Oct;12(10):597-605. doi: 10.1097/GIM.0b013e3181eed412. PMID: 20847697
David LR, Argenta LC, Venes J, Wilson J, Glazier S
J Craniofac Surg 1998 Jan;9(1):3-10. doi: 10.1097/00001665-199801000-00003. PMID: 9558561
Orlow SJ, Watsky KL, Bolognia JL
J Am Acad Dermatol 1991 Aug;25(2 Pt 1):205-21. doi: 10.1016/0190-9622(91)70185-5. PMID: 1918456

Diagnosis

Colombi M, Dordoni C, Chiarelli N, Ritelli M
Am J Med Genet C Semin Med Genet 2015 Mar;169C(1):6-22. doi: 10.1002/ajmg.c.31429. PMID: 25821090
Huang JT, Liang MG
Pediatr Clin North Am 2010 Oct;57(5):1091-110. doi: 10.1016/j.pcl.2010.08.003. PMID: 20888460
Malfait F, Wenstrup RJ, De Paepe A
Genet Med 2010 Oct;12(10):597-605. doi: 10.1097/GIM.0b013e3181eed412. PMID: 20847697
Allanson JE
J Med Genet 1987 Jan;24(1):9-13. doi: 10.1136/jmg.24.1.9. PMID: 3543368Free PMC Article
Walker BA, Scott CI, Hall JG, Murdoch JL, McKusick VA
Medicine (Baltimore) 1972 Jan;51(1):41-59. doi: 10.1097/00005792-197201000-00003. PMID: 4621588

Therapy

Bina S, Pacey V, Barnes EH, Burns J, Gray K
Cochrane Database Syst Rev 2020 May 15;5(5):CD008602. doi: 10.1002/14651858.CD008602.pub4. PMID: 32412098Free PMC Article
Cao Y, Hong Y, Xu Y, Zhu Y, Xu X
J Orthop Surg Res 2018 Jun 25;13(1):159. doi: 10.1186/s13018-018-0870-6. PMID: 29940985Free PMC Article
Judge DP, Dietz HC
Lancet 2005 Dec 3;366(9501):1965-76. doi: 10.1016/S0140-6736(05)67789-6. PMID: 16325700Free PMC Article
McBride WG
Teratology 1977 Aug;16(1):79-82. doi: 10.1002/tera.1420160113. PMID: 331548
Br Med J 1951 Oct 20;2(4737):955-6. PMID: 14869779Free PMC Article

Prognosis

Saeidian AH, Youssefian L, Huang J, Touati A, Vahidnezhad H, Kowal L, Caffet M, Wurst T, Singh J, Snook AE, Ryu E, Fortina P, Terry SF, Schoenecker JG, Uitto J, Li Q
Genet Med 2022 Jan;24(1):75-86. Epub 2021 Nov 30 doi: 10.1016/j.gim.2021.08.011. PMID: 34906475Free PMC Article
Saw J, Humphries K, Aymong E, Sedlak T, Prakash R, Starovoytov A, Mancini GBJ
J Am Coll Cardiol 2017 Aug 29;70(9):1148-1158. doi: 10.1016/j.jacc.2017.06.053. PMID: 28838364
Bhatia S, Holla RG
Indian Pediatr 2005 Apr;42(4):373-5. PMID: 15876600
Kulkarni ML, Kumar CS, Venkataramana V, George VG, Bhagyavathi M
Indian Pediatr 1995 Jan;32(1):82-7. PMID: 8617541
Hirst AE Jr, Gore I
Prog Cardiovasc Dis 1973 Sep-Oct;16(2):187-98. doi: 10.1016/s0033-0620(73)80013-1. PMID: 4592844

Clinical prediction guides

Alsiri N, Alhadhoud M, Alkatefi T, Palmer S
Semin Arthritis Rheum 2023 Feb;58:152127. Epub 2022 Nov 17 doi: 10.1016/j.semarthrit.2022.152127. PMID: 36462303
Saeidian AH, Youssefian L, Huang J, Touati A, Vahidnezhad H, Kowal L, Caffet M, Wurst T, Singh J, Snook AE, Ryu E, Fortina P, Terry SF, Schoenecker JG, Uitto J, Li Q
Genet Med 2022 Jan;24(1):75-86. Epub 2021 Nov 30 doi: 10.1016/j.gim.2021.08.011. PMID: 34906475Free PMC Article
Malfait F, Wenstrup RJ, De Paepe A
Genet Med 2010 Oct;12(10):597-605. doi: 10.1097/GIM.0b013e3181eed412. PMID: 20847697
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article
Tekin M, Kavaz A, Berberoğlu M, Fitoz S, Ekim M, Ocal G, Akar N
Am J Med Genet A 2004 Oct 15;130A(3):284-7. doi: 10.1002/ajmg.a.30291. PMID: 15378538

Recent systematic reviews

Bril F, Ezeh U, Amiri M, Hatoum S, Pace L, Chen YH, Bertrand F, Gower B, Azziz R
J Clin Endocrinol Metab 2023 Dec 21;109(1):10-24. doi: 10.1210/clinem/dgad356. PMID: 37329216Free PMC Article
Leszczynski R, da Silva CA, Pinto ACPN, Kuczynski U, da Silva EM
Cochrane Database Syst Rev 2022 Sep 26;9(9):CD011642. doi: 10.1002/14651858.CD011642.pub2. PMID: 36161591Free PMC Article
Thwaites PA, Gibson PR, Burgell RE
J Gastroenterol Hepatol 2022 Sep;37(9):1693-1709. Epub 2022 Jul 20 doi: 10.1111/jgh.15927. PMID: 35750466Free PMC Article
Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R
Int J Cardiol 2022 Sep 1;362:158-167. Epub 2022 Jun 1 doi: 10.1016/j.ijcard.2022.05.065. PMID: 35662564
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article

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