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Allergic rhinitis, susceptibility to

MedGen UID:
865977
Concept ID:
C4017540
Finding
Synonym: ALLERGIC RHINITIS, SUSCEPTIBILITY TO
 
Gene (location): IL13 (5q31.1)
 
Monarch Initiative: MONDO:0100177
OMIM®: 607154

Definition

An inherited susceptibility or predisposition to developing allergic rhinitis. [from MONDO]

Professional guidelines

PubMed

Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K; Japanese Society of Allergology
Allergol Int 2020 Jul;69(3):331-345. Epub 2020 May 27 doi: 10.1016/j.alit.2020.04.001. PMID: 32473790
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Recent clinical studies

Etiology

Cayrol C, Girard JP
Cytokine 2022 Aug;156:155891. Epub 2022 May 25 doi: 10.1016/j.cyto.2022.155891. PMID: 35640416
Langan SM, Irvine AD, Weidinger S
Lancet 2020 Aug 1;396(10247):345-360. doi: 10.1016/S0140-6736(20)31286-1. PMID: 32738956
Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD
J Allergy Clin Immunol 2019 Jan;143(1):46-55. Epub 2018 Nov 17 doi: 10.1016/j.jaci.2018.11.006. PMID: 30458183
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL
Nat Genet 2018 Jan;50(1):42-53. Epub 2017 Dec 22 doi: 10.1038/s41588-017-0014-7. PMID: 29273806Free PMC Article

Diagnosis

Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K; Japanese Society of Allergology
Allergol Int 2020 Jul;69(3):331-345. Epub 2020 May 27 doi: 10.1016/j.alit.2020.04.001. PMID: 32473790
Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY
Asian Pac J Allergy Immunol 2020 Dec;38(4):251-257. doi: 10.12932/AP-070918-0403. PMID: 31012599
Watson J, Schobitz E, Davis J
Am J Emerg Med 2018 Jan;36(1):171.e5-171.e6. Epub 2017 Oct 16 doi: 10.1016/j.ajem.2017.10.040. PMID: 29070434
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Therapy

Zhang HP, Sun YL, Wang YF, Yazici D, Azkur D, Ogulur I, Azkur AK, Yang ZW, Chen XX, Zhang AZ, Hu JQ, Liu GH, Akdis M, Akdis CA, Gao YD
Allergy 2023 Feb;78(2):369-388. Epub 2022 Dec 5 doi: 10.1111/all.15593. PMID: 36420736Free PMC Article
Li L, Liu R, Peng C, Chen X, Li J
Exp Dermatol 2022 Jul;31(7):993-1004. Epub 2022 May 17 doi: 10.1111/exd.14602. PMID: 35538735
Pacheco SE, Guidos-Fogelbach G, Annesi-Maesano I, Pawankar R, D' Amato G, Latour-Staffeld P, Urrutia-Pereira M, Kesic MJ, Hernandez ML; American Academy of Allergy, Asthma & Immunology Environmental Exposures and Respiratory Health Committee
J Allergy Clin Immunol 2021 Dec;148(6):1366-1377. Epub 2021 Oct 21 doi: 10.1016/j.jaci.2021.10.011. PMID: 34688774
Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD
Nat Rev Dis Primers 2018 Jun 21;4(1):1. doi: 10.1038/s41572-018-0001-z. PMID: 29930242
Watson J, Schobitz E, Davis J
Am J Emerg Med 2018 Jan;36(1):171.e5-171.e6. Epub 2017 Oct 16 doi: 10.1016/j.ajem.2017.10.040. PMID: 29070434

Prognosis

Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Dinakar C, Ellis AK, Finegold I, Golden DBK, Greenhawt MJ, Hagan JB, Horner CC, Khan DA, Lang DM, Larenas-Linnemann DES, Lieberman JA, Meltzer EO, Oppenheimer JJ, Rank MA, Shaker MS, Shaw JL, Steven GC, Stukus DR, Wang J; Chief Editor(s):, Dykewicz MS, Wallace DV; Joint Task Force on Practice Parameters:, Dinakar C, Ellis AK, Golden DBK, Greenhawt MJ, Horner CC, Khan DA, Lang DM, Lieberman JA, Oppenheimer JJ, Rank MA, Shaker MS, Stukus DR, Wang J; Workgroup Contributors:, Dykewicz MS, Wallace DV, Amrol DJ, Baroody FM, Bernstein JA, Craig TJ, Finegold I, Hagan JB, Larenas-Linnemann DES, Meltzer EO, Shaw JL, Steven GC
J Allergy Clin Immunol 2020 Oct;146(4):721-767. Epub 2020 Jul 22 doi: 10.1016/j.jaci.2020.07.007. PMID: 32707227
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD
J Allergy Clin Immunol 2019 Jan;143(1):46-55. Epub 2018 Nov 17 doi: 10.1016/j.jaci.2018.11.006. PMID: 30458183
Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD
Nat Rev Dis Primers 2018 Jun 21;4(1):1. doi: 10.1038/s41572-018-0001-z. PMID: 29930242
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Clinical prediction guides

Elhage KG, Kranyak A, Jin JQ, Haran K, Spencer RK, Smith PL, Davis MS, Hakimi M, Bhutani T, Liao W
J Invest Dermatol 2024 May;144(5):1022-1037. Epub 2023 Nov 17 doi: 10.1016/j.jid.2023.10.016. PMID: 37977498
Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY
Asian Pac J Allergy Immunol 2020 Dec;38(4):251-257. doi: 10.12932/AP-070918-0403. PMID: 31012599
Verschoor D, von Gunten S
Int Arch Allergy Immunol 2019;180(4):235-243. Epub 2019 Nov 6 doi: 10.1159/000504439. PMID: 31694044
Paller AS, Spergel JM, Mina-Osorio P, Irvine AD
J Allergy Clin Immunol 2019 Jan;143(1):46-55. Epub 2018 Nov 17 doi: 10.1016/j.jaci.2018.11.006. PMID: 30458183
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Recent systematic reviews

Elhage KG, Kranyak A, Jin JQ, Haran K, Spencer RK, Smith PL, Davis MS, Hakimi M, Bhutani T, Liao W
J Invest Dermatol 2024 May;144(5):1022-1037. Epub 2023 Nov 17 doi: 10.1016/j.jid.2023.10.016. PMID: 37977498
Chen K, Hou C, Liu C, Meng Y
Medicine (Baltimore) 2023 Mar 3;102(9):e32997. doi: 10.1097/MD.0000000000032997. PMID: 36862898Free PMC Article
Proper SP, Azouz NP, Mersha TB
Front Immunol 2021;12:720746. Epub 2021 Aug 18 doi: 10.3389/fimmu.2021.720746. PMID: 34484229Free PMC Article
Tamasauskiene L, Sitkauskiene B
J Interferon Cytokine Res 2020 Mar;40(3):125-130. Epub 2019 Dec 31 doi: 10.1089/jir.2019.0094. PMID: 31895598
Huang RF, Dong P, Zhang TZ, Ying XJ, Hu H
Eur Arch Otorhinolaryngol 2016 Feb;273(2):277-83. Epub 2014 Oct 24 doi: 10.1007/s00405-014-3350-6. PMID: 25341696

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