Greek HPFH

MedGen UID:: 865974
•Concept ID:: C4017537
•: Finding

Synonym:	GREEK HPFH

OMIM®:	142200

Recent clinical studies

Therapy

Use of the hereditary persistence of fetal hemoglobin 2 enhancer to increase the expression of oncoretrovirus vectors for human gamma-globin.

Fragkos M, Anagnou NP, Tubb J, Emery DW
Gene Ther 2005 Nov;12(21):1591-600. doi: 10.1038/sj.gt.3302566. PMID: 15944728

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Prognosis

A frequent A gamma-hereditary persistence of fetal hemoglobin in northern Sardinia: its molecular basis and hematologic phenotype in heterozygotes and compound heterozygotes with beta-thalassemia.

Ottolenghi S, Camaschella C, Comi P, Giglioni B, Longinotti M, Oggiano L, Dore F, Sciarratta G, Ivaldi G, Saglio G
Hum Genet 1988 May;79(1):13-7. doi: 10.1007/BF00291702. PMID: 2452784

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Clinical prediction guides

Regulation of human fetal and adult globin genes in mouse erythroleukemia cells.

Morley BJ, Abbott CA, Wood WG
Blood 1991 Sep 1;78(5):1355-63. PMID: 1878596

Greek (A gamma) variant of hereditary persistence of fetal haemoglobin: globin gene organization and studies of expression of fetal haemoglobins in clonal erythroid cultures.

Papayannopoulou T, Lawn RM, Stamatoyannopoulos G, Maniatis T
Br J Haematol 1982 Mar;50(3):387-99. doi: 10.1111/j.1365-2141.1982.tb01934.x. PMID: 6175332

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Greek HPFH

Recent clinical studies

Therapy

Prognosis

Clinical prediction guides

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