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RENAL CELL CARCINOMA WITH PARANEOPLASTIC ERYTHROCYTOSIS

MedGen UID:
865598
•Concept ID:
C4017161
•
Finding
OMIM®: 608537

Recent clinical studies

Etiology

Paraneoplastic syndromes are associated with adverse prognosis among patients with renal cell carcinoma undergoing nephrectomy.
Moreira DM, Gershman B, Lohse CM, Boorjian SA, Cheville JC, Leibovich BC, Thompson RH
World J Urol 2016 Oct;34(10):1465-72. Epub 2016 Feb 25 doi: 10.1007/s00345-016-1793-7. PMID: 26914818
Is there an association between advanced stage of renal cell carcinoma and paraneoplastic syndrome?
Ding GX, Song NH, Feng CC, Xia GW, Jiang HW, Hua LX, Ding Q
Med Princ Pract 2012;21(4):370-4. Epub 2012 Jan 6 doi: 10.1159/000334873. PMID: 22237047

Diagnosis

Polycythemia Secondary to Renal Hemangioblastoma: A Case Report and Literature Review.
Lee Y, Cheng SM, Hwang DY, Chiu YL, Chou YH
Int J Surg Pathol 2024 Feb;32(1):140-144. Epub 2023 May 7 doi: 10.1177/10668969231171133. PMID: 37150964
Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera.
Guo R, Liang Y, Yan L, Xu Z, Ren J
Chin J Cancer 2017 Sep 6;36(1):72. doi: 10.1186/s40880-017-0238-z. PMID: 28877745Free PMC Article
Paraneoplastic syndromes are associated with adverse prognosis among patients with renal cell carcinoma undergoing nephrectomy.
Moreira DM, Gershman B, Lohse CM, Boorjian SA, Cheville JC, Leibovich BC, Thompson RH
World J Urol 2016 Oct;34(10):1465-72. Epub 2016 Feb 25 doi: 10.1007/s00345-016-1793-7. PMID: 26914818
Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma.
Ding GX, Feng CC, Song NH, Fang ZJ, Xia GW, Jiang HW, Hua LX, Ding Q
Urol Oncol 2013 Nov;31(8):1820-5. Epub 2012 Apr 24 doi: 10.1016/j.urolonc.2012.03.021. PMID: 22534085
Extrarenal manifestations of renal cell carcinoma.
Marshall FF, Walsh PC
J Urol 1977 Apr;117(4):439-40. doi: 10.1016/s0022-5347(17)58491-8. PMID: 850316

Therapy

A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma.
Brugarolas J, Obara G, Beckermann KE, Rini B, Lam ET, Hamilton J, Schluep T, Yi M, Wong S, Mao ZL, Gamelin E, Tannir NM
Clin Cancer Res 2024 Jun 3;30(11):2402-2411. doi: 10.1158/1078-0432.CCR-23-3029. PMID: 38652038Free PMC Article
HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans.
Ma Y, Joyce A, Brandenburg O, Saatchi F, Stevens C, Toffessi Tcheuyap V, Christie A, Do QN, Fatunde O, Macchiaroli A, Wong SC, Woolford L, Yousuf Q, Miyata J, Carrillo D, Onabolu O, McKenzie T, Mishra A, Hardy T, He W, Li D, Ivanishev A, Zhang Q, Pedrosa I, Kapur P, Schluep T, Kanner SB, Hamilton J, Brugarolas J
Clin Cancer Res 2022 Dec 15;28(24):5405-5418. doi: 10.1158/1078-0432.CCR-22-0963. PMID: 36190432Free PMC Article

Prognosis

Paraneoplastic syndromes are associated with adverse prognosis among patients with renal cell carcinoma undergoing nephrectomy.
Moreira DM, Gershman B, Lohse CM, Boorjian SA, Cheville JC, Leibovich BC, Thompson RH
World J Urol 2016 Oct;34(10):1465-72. Epub 2016 Feb 25 doi: 10.1007/s00345-016-1793-7. PMID: 26914818
Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma.
Wiesener MS, Seyfarth M, Warnecke C, Jürgensen JS, Rosenberger C, Morgan NV, Maher ER, Frei U, Eckardt KU
Blood 2002 May 15;99(10):3562-5. doi: 10.1182/blood.v99.10.3562. PMID: 11986208

Clinical prediction guides

A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma.
Brugarolas J, Obara G, Beckermann KE, Rini B, Lam ET, Hamilton J, Schluep T, Yi M, Wong S, Mao ZL, Gamelin E, Tannir NM
Clin Cancer Res 2024 Jun 3;30(11):2402-2411. doi: 10.1158/1078-0432.CCR-23-3029. PMID: 38652038Free PMC Article
Polycythemia Secondary to Renal Hemangioblastoma: A Case Report and Literature Review.
Lee Y, Cheng SM, Hwang DY, Chiu YL, Chou YH
Int J Surg Pathol 2024 Feb;32(1):140-144. Epub 2023 May 7 doi: 10.1177/10668969231171133. PMID: 37150964
A man with a deltoid swelling and paraneoplastic erythrocytosis: case report.
Alimonti A, Di Cosimo S, Maccallini V, Ferretti G, Pavese I, Satta F, Di Palma M, Vecchione A
Anticancer Res 2003 Nov-Dec;23(6D):5181-4. PMID: 14981986
Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma.
Wiesener MS, Seyfarth M, Warnecke C, Jürgensen JS, Rosenberger C, Morgan NV, Maher ER, Frei U, Eckardt KU
Blood 2002 May 15;99(10):3562-5. doi: 10.1182/blood.v99.10.3562. PMID: 11986208
Erythropoietin immunolocalization in renal cell carcinoma.
Clark D, Kersting R, Rojiani AM
Mod Pathol 1998 Jan;11(1):24-8. PMID: 9556419

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