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Bladder cancer, transitional cell, somatic

MedGen UID:
864840
•Concept ID:
C4016403
•
Neoplastic Process
Synonym: BLADDER CANCER, TRANSITIONAL CELL, SOMATIC
 
OMIM®: 190070

Professional guidelines

PubMed

Clinical Utility of Serial Circulating Tumor DNA Analysis as a Minimally Invasive Biomarker in Advanced Urothelial Cancer.
Sakatani T, Sumiyoshi T, Kita Y, Takada H, Nakamura K, Hamada A, Murakami K, Sano T, Goto T, Sawada A, Akamatsu S, Saito R, Kobayashi T
JCO Precis Oncol 2025 Jan;9:e2400472. Epub 2025 Jan 6 doi: 10.1200/PO-24-00472. PMID: 39761498
Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer.
Helal C, Pobel C, Bayle A, Vasseur D, Nicotra C, Blanc-Durand F, Naoun N, Bernard-Tessier A, Patrikidou A, Colomba E, Flippot R, Fuerea A, Auger N, Ngo Camus M, Besse B, Lacroix L, Rouleau E, Ponce S, Italiano A, Loriot Y
Eur J Cancer 2023 Dec;195:113368. Epub 2023 Oct 6 doi: 10.1016/j.ejca.2023.113368. PMID: 37897866
Systemic treatment of advanced and metastatic urothelial cancer: The landscape in Australia.
Gurney H, Clay TD, Oliveira N, Wong S, Tran B, Harris C
Asia Pac J Clin Oncol 2023 Dec;19(6):585-595. Epub 2023 Sep 20 doi: 10.1111/ajco.14001. PMID: 37727139

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

Recent clinical studies

Etiology

FGFR Inhibition in Urothelial Carcinoma.
Li R, Linscott J, Catto JWF, Daneshmand S, Faltas BM, Kamat AM, Meeks JJ, Necchi A, Pradere B, Ross JS, van der Heijden MS, van Rhijn BWG, Loriot Y
Eur Urol 2025 Feb;87(2):110-122. Epub 2024 Sep 30 doi: 10.1016/j.eururo.2024.09.012. PMID: 39353825
DNA-Damage-Repair Gene Alterations in Genitourinary Malignancies.
Dariane C, Timsit MO
Eur Surg Res 2022;63(4):155-164. Epub 2022 Aug 9 doi: 10.1159/000526415. PMID: 35944490
Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience.
Rose TL, Weir WH, Mayhew GM, Shibata Y, Eulitt P, Uronis JM, Zhou M, Nielsen M, Smith AB, Woods M, Hayward MC, Salazar AH, Milowsky MI, Wobker SE, McGinty K, Millburn MV, Eisner JR, Kim WY
Br J Cancer 2021 Oct;125(9):1251-1260. Epub 2021 Jul 22 doi: 10.1038/s41416-021-01488-6. PMID: 34294892Free PMC Article
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Sweis RF, Galsky MD
Urol Oncol 2016 Dec;34(12):556-565. Epub 2016 Nov 9 doi: 10.1016/j.urolonc.2016.10.006. PMID: 27836246Free PMC Article
Molecular pathogenesis of bladder cancer.
Knowles MA
Int J Clin Oncol 2008 Aug;13(4):287-97. Epub 2008 Aug 15 doi: 10.1007/s10147-008-0812-0. PMID: 18704628

Diagnosis

Molecular Pathology of Urothelial Carcinoma.
Al-Ahmadie H, Netto GJ
Clin Lab Med 2024 Jun;44(2):181-198. doi: 10.1016/j.cll.2023.08.010. PMID: 38821640
DNA-Damage-Repair Gene Alterations in Genitourinary Malignancies.
Dariane C, Timsit MO
Eur Surg Res 2022;63(4):155-164. Epub 2022 Aug 9 doi: 10.1159/000526415. PMID: 35944490
Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.
Zhang R, Zang J, Xie F, Zhang Y, Wang Y, Jing Y, Zhang Y, Chen Z, Shahatiaili A, Cai MC, Zhao Z, Du P, Jia S, Zhuang G, Chen H
J Urol 2021 Oct;206(4):873-884. Epub 2021 Jun 1 doi: 10.1097/JU.0000000000001878. PMID: 34061567
Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.
Genitsch V, Kollár A, Vandekerkhove G, Blarer J, Furrer M, Annala M, Herberts C, Pycha A, de Jong JJ, Liu Y, Krentel F, Davicioni E, Gibb EA, Kruithof-de Julio M, Wyatt AW, Seiler R
Urol Oncol 2019 Nov;37(11):826-836. Epub 2019 Oct 1 doi: 10.1016/j.urolonc.2019.09.025. PMID: 31585777
FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review).
Katoh Y, Katoh M
Int J Mol Med 2009 Mar;23(3):307-11. doi: 10.3892/ijmm_00000132. PMID: 19212647

Therapy

FGFR Inhibition in Urothelial Carcinoma.
Li R, Linscott J, Catto JWF, Daneshmand S, Faltas BM, Kamat AM, Meeks JJ, Necchi A, Pradere B, Ross JS, van der Heijden MS, van Rhijn BWG, Loriot Y
Eur Urol 2025 Feb;87(2):110-122. Epub 2024 Sep 30 doi: 10.1016/j.eururo.2024.09.012. PMID: 39353825
Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer.
Helal C, Pobel C, Bayle A, Vasseur D, Nicotra C, Blanc-Durand F, Naoun N, Bernard-Tessier A, Patrikidou A, Colomba E, Flippot R, Fuerea A, Auger N, Ngo Camus M, Besse B, Lacroix L, Rouleau E, Ponce S, Italiano A, Loriot Y
Eur J Cancer 2023 Dec;195:113368. Epub 2023 Oct 6 doi: 10.1016/j.ejca.2023.113368. PMID: 37897866
DNA-Damage-Repair Gene Alterations in Genitourinary Malignancies.
Dariane C, Timsit MO
Eur Surg Res 2022;63(4):155-164. Epub 2022 Aug 9 doi: 10.1159/000526415. PMID: 35944490
Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience.
Rose TL, Weir WH, Mayhew GM, Shibata Y, Eulitt P, Uronis JM, Zhou M, Nielsen M, Smith AB, Woods M, Hayward MC, Salazar AH, Milowsky MI, Wobker SE, McGinty K, Millburn MV, Eisner JR, Kim WY
Br J Cancer 2021 Oct;125(9):1251-1260. Epub 2021 Jul 22 doi: 10.1038/s41416-021-01488-6. PMID: 34294892Free PMC Article
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Sweis RF, Galsky MD
Urol Oncol 2016 Dec;34(12):556-565. Epub 2016 Nov 9 doi: 10.1016/j.urolonc.2016.10.006. PMID: 27836246Free PMC Article

Prognosis

FGFR Inhibition in Urothelial Carcinoma.
Li R, Linscott J, Catto JWF, Daneshmand S, Faltas BM, Kamat AM, Meeks JJ, Necchi A, Pradere B, Ross JS, van der Heijden MS, van Rhijn BWG, Loriot Y
Eur Urol 2025 Feb;87(2):110-122. Epub 2024 Sep 30 doi: 10.1016/j.eururo.2024.09.012. PMID: 39353825
Nested and Large Nested Subtypes of Urothelial Carcinoma of the Upper Urinary Tract: A Multi-institutional Study.
Aron M, Chandrashekar DS, Canete-Portillo S, Brimo F, Williamson SR, Osunkoya AO, Raspollini MR, Kunju LP, Varambally S, Mackinnon AC, Harada S, Netto GJ
Mod Pathol 2023 Dec;36(12):100333. Epub 2023 Sep 15 doi: 10.1016/j.modpat.2023.100333. PMID: 37717923
Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.
Zhang R, Zang J, Xie F, Zhang Y, Wang Y, Jing Y, Zhang Y, Chen Z, Shahatiaili A, Cai MC, Zhao Z, Du P, Jia S, Zhuang G, Chen H
J Urol 2021 Oct;206(4):873-884. Epub 2021 Jun 1 doi: 10.1097/JU.0000000000001878. PMID: 34061567
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Sweis RF, Galsky MD
Urol Oncol 2016 Dec;34(12):556-565. Epub 2016 Nov 9 doi: 10.1016/j.urolonc.2016.10.006. PMID: 27836246Free PMC Article
The clinical and histopathological significance of Feulgen DNA-values in transitional cell carcinoma of the human urinary bladder.
Fossa SD, Kaalhus O, Scott-Knudsen O
Eur J Cancer (1965) 1977 Oct;13(10):1155-62. doi: 10.1016/0014-2964(77)90015-9. PMID: 72669

Clinical prediction guides

Integrated longitudinal circulating tumor DNA profiling predicts immunotherapy response of metastatic urothelial carcinoma in the POLARIS-03 trial.
Zang J, Zhang R, Jin D, Xie F, Shahatiaili A, Wu G, Zhang Y, Zhao Z, Du P, Jia S, Chen H, Zhuang G
J Pathol 2023 Oct;261(2):198-209. Epub 2023 Aug 16 doi: 10.1002/path.6166. PMID: 37584165
DNA-Damage-Repair Gene Alterations in Genitourinary Malignancies.
Dariane C, Timsit MO
Eur Surg Res 2022;63(4):155-164. Epub 2022 Aug 9 doi: 10.1159/000526415. PMID: 35944490
Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience.
Rose TL, Weir WH, Mayhew GM, Shibata Y, Eulitt P, Uronis JM, Zhou M, Nielsen M, Smith AB, Woods M, Hayward MC, Salazar AH, Milowsky MI, Wobker SE, McGinty K, Millburn MV, Eisner JR, Kim WY
Br J Cancer 2021 Oct;125(9):1251-1260. Epub 2021 Jul 22 doi: 10.1038/s41416-021-01488-6. PMID: 34294892Free PMC Article
Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.
Zhang R, Zang J, Xie F, Zhang Y, Wang Y, Jing Y, Zhang Y, Chen Z, Shahatiaili A, Cai MC, Zhao Z, Du P, Jia S, Zhuang G, Chen H
J Urol 2021 Oct;206(4):873-884. Epub 2021 Jun 1 doi: 10.1097/JU.0000000000001878. PMID: 34061567
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.
Sweis RF, Galsky MD
Urol Oncol 2016 Dec;34(12):556-565. Epub 2016 Nov 9 doi: 10.1016/j.urolonc.2016.10.006. PMID: 27836246Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

    Consumer resources

    Reviews

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