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Adrenocortical tumor, somatic

MedGen UID:
864829
•Concept ID:
C4016392
•
Neoplastic Process
Synonym: Adrenal cortical tumor, somatic
 
OMIM®: 188830

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

Recent clinical studies

Etiology

Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol.
Rodriguez-Galindo C, Krailo MD, Pinto EM, Pashankar F, Weldon CB, Huang L, Caran EM, Hicks J, McCarville MB, Malkin D, Wasserman JD, de Oliveira Filho AG, LaQuaglia MP, Ward DA, Zambetti G, Mastellaro MJ, Pappo AS, Ribeiro RC
J Clin Oncol 2021 Aug 1;39(22):2463-2473. Epub 2021 Apr 6 doi: 10.1200/JCO.20.02871. PMID: 33822640Free PMC Article
Disordered CYP11B2 Expression in Primary Aldosteronism.
Gomez-Sanchez CE, Kuppusamy M, Reincke M, Williams TA
Horm Metab Res 2017 Dec;49(12):957-962. Epub 2017 Dec 4 doi: 10.1055/s-0043-122238. PMID: 29202495
Aldosterone-Producing Cell Clusters in Normal and Pathological States.
Omata K, Tomlins SA, Rainey WE
Horm Metab Res 2017 Dec;49(12):951-956. Epub 2017 Dec 4 doi: 10.1055/s-0043-122394. PMID: 29202494Free PMC Article
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.
Dalmazi GD, Beuschlein F
Horm Metab Res 2017 Apr;49(4):301-306. Epub 2016 Nov 21 doi: 10.1055/s-0042-120416. PMID: 27871112
Genetic disorders in primary aldosteronism-familial and somatic.
Funder JW
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):154-157. Epub 2016 Mar 21 doi: 10.1016/j.jsbmb.2016.03.020. PMID: 27013018

Diagnosis

Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Timeline of Advances in Genetics of Primary Aldosteronism.
Meyer LS, Reincke M, Williams TA
Exp Suppl 2019;111:213-243. doi: 10.1007/978-3-030-25905-1_11. PMID: 31588534
Genetic disorders in primary aldosteronism-familial and somatic.
Funder JW
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):154-157. Epub 2016 Mar 21 doi: 10.1016/j.jsbmb.2016.03.020. PMID: 27013018
Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.
Stratakis CA
Endocrinol Metab Clin North Am 2016 Jun;45(2):311-28. doi: 10.1016/j.ecl.2016.01.006. PMID: 27241967Free PMC Article
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203

Therapy

Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol.
Rodriguez-Galindo C, Krailo MD, Pinto EM, Pashankar F, Weldon CB, Huang L, Caran EM, Hicks J, McCarville MB, Malkin D, Wasserman JD, de Oliveira Filho AG, LaQuaglia MP, Ward DA, Zambetti G, Mastellaro MJ, Pappo AS, Ribeiro RC
J Clin Oncol 2021 Aug 1;39(22):2463-2473. Epub 2021 Apr 6 doi: 10.1200/JCO.20.02871. PMID: 33822640Free PMC Article
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article
Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center.
Nelson CA, Noe MH, McMahon CM, Gowda A, Wu B, Ashchyan HJ, Perl AE, James WD, Micheletti RG, Rosenbach M
J Am Acad Dermatol 2018 Feb;78(2):303-309.e4. Epub 2017 Oct 26 doi: 10.1016/j.jaad.2017.09.013. PMID: 29107342
ILVEN - COMPLETE REMISSION AFTER ADMINISTRATION OF TOPICAL CORTICOSTEROID (CASE REVIEW).
Wollina U, Tchernev G
Georgian Med News 2017 Feb;(263):10-13. PMID: 28452721
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

Prognosis

Advances in translational research of the rare cancer type adrenocortical carcinoma.
Ghosh C, Hu J, Kebebew E
Nat Rev Cancer 2023 Dec;23(12):805-824. Epub 2023 Oct 19 doi: 10.1038/s41568-023-00623-0. PMID: 37857840
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome.
Santana LS, Guimaraes AG, Almeida MQ
Front Endocrinol (Lausanne) 2022;13:927669. Epub 2022 Jun 23 doi: 10.3389/fendo.2022.927669. PMID: 35813615Free PMC Article
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
Chueh JS, Peng KY, Wu VC, Wang SM, Chan CK, Chen YM, Ke YY, Pan CY, Liao HW
J Mol Endocrinol 2021 Sep 28;67(4):203-215. doi: 10.1530/JME-20-0282. PMID: 34463641
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

Clinical prediction guides

Targeted Mutational Analysis of Cortisol-Producing Adenomas.
Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K
J Clin Endocrinol Metab 2022 Jan 18;107(2):e594-e603. doi: 10.1210/clinem/dgab682. PMID: 34534321Free PMC Article
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Åkerström T, Maharjan R, Sven Willenberg H, Cupisti K, Ip J, Moser A, Stålberg P, Robinson B, Alexander Iwen K, Dralle H, Walz MK, Lehnert H, Sidhu S, Gomez-Sanchez C, Hellman P, Björklund P
Sci Rep 2016 Jan 27;6:19546. doi: 10.1038/srep19546. PMID: 26815163Free PMC Article
Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
Drougat L, Espiard S, Bertherat J
Eur J Endocrinol 2015 Oct;173(4):M121-31. Epub 2015 Aug 11 doi: 10.1530/EJE-15-0532. PMID: 26264719
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

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