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GLUCOCORTICOID RESISTANCE, CELLULAR

MedGen UID:
864549
•Concept ID:
C4016112
•
Finding
OMIM®: 138040

Professional guidelines

PubMed

Glucocorticoids in the Treatment of Glomerular Diseases: Pitfalls and Pearls.
Ponticelli C, Locatelli F
Clin J Am Soc Nephrol 2018 May 7;13(5):815-822. Epub 2018 Feb 23 doi: 10.2215/CJN.12991117. PMID: 29475991Free PMC Article
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease.
Urzua CA, Guerrero J, Gatica H, Velasquez V, Goecke A
Invest Ophthalmol Vis Sci 2017 Feb 1;58(2):974-980. doi: 10.1167/iovs.16-20783. PMID: 28535268
The glucocorticoid receptor: pivot of depression and of antidepressant treatment?
Anacker C, Zunszain PA, Carvalho LA, Pariante CM
Psychoneuroendocrinology 2011 Apr;36(3):415-25. doi: 10.1016/j.psyneuen.2010.03.007. PMID: 20399565Free PMC Article

Recent clinical studies

Etiology

Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia.
Sarno J, Domizi P, Liu Y, Merchant M, Pedersen CB, Jedoui D, Jager A, Nolan GP, Gaipa G, Bendall SC, Bava FA, Davis KL
Nat Commun 2023 May 22;14(1):2935. doi: 10.1038/s41467-023-38456-y. PMID: 37217509Free PMC Article
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma.
Palumbo ML, Prochnik A, Wald MR, Genaro AM
Clin Ther 2020 Jun;42(6):993-1006. Epub 2020 Mar 26 doi: 10.1016/j.clinthera.2020.03.002. PMID: 32224031
Suppressive effect of glucocorticoids on TNF-alpha production is associated with their clinical effect in multiple sclerosis.
van Winsen LM, Polman CH, Dijkstra CD, Tilders FJ, Uitdehaag BM
Mult Scler 2010 Apr;16(4):500-2. Epub 2010 Jan 19 doi: 10.1177/1352458509359721. PMID: 20086025
Stress and multiple sclerosis.
Mohr DC
J Neurol 2007 May;254 Suppl 2:II65-8. doi: 10.1007/s00415-007-2015-4. PMID: 17503132
Glucocorticoid-resistant asthma. T-lymphocyte defects.
Corrigan CJ
Am J Respir Crit Care Med 1996 Aug;154(2 Pt 2):S53-5; discussion S55-7. doi: 10.1164/ajrccm/154.2_Pt_2.S53. PMID: 8756789

Diagnosis

Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia.
Sarno J, Domizi P, Liu Y, Merchant M, Pedersen CB, Jedoui D, Jager A, Nolan GP, Gaipa G, Bendall SC, Bava FA, Davis KL
Nat Commun 2023 May 22;14(1):2935. doi: 10.1038/s41467-023-38456-y. PMID: 37217509Free PMC Article
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma.
Palumbo ML, Prochnik A, Wald MR, Genaro AM
Clin Ther 2020 Jun;42(6):993-1006. Epub 2020 Mar 26 doi: 10.1016/j.clinthera.2020.03.002. PMID: 32224031
Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
Sai S, Esteves C, Kelly V, Sakaguchi K, McAndrew R, Chudleigh S, Spence A, Gibson B, Thomas A, Chapman KE
J Pediatr 2020 May;220:249-253. Epub 2020 Jan 24 doi: 10.1016/j.jpeds.2019.12.054. PMID: 31987650
Timing and crosstalk of glucocorticoid signaling with cytokines, neurotransmitters and growth factors.
Arango-Lievano M, Jeanneteau F
Pharmacol Res 2016 Nov;113(Pt A):1-17. Epub 2016 Aug 3 doi: 10.1016/j.phrs.2016.08.005. PMID: 27498156
Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK.
Yang N, Caratti G, Ince LM, Poolman TM, Trebble PJ, Holt CM, Ray DW, Matthews LC
J Endocrinol 2014 Nov;223(2):155-66. Epub 2014 Aug 26 doi: 10.1530/JOE-14-0456. PMID: 25161081Free PMC Article

Therapy

Th17 Cells, Glucocorticoid Resistance, and Depression.
Khantakova JN, Mutovina A, Ayriyants KA, Bondar NP
Cells 2023 Nov 30;12(23) doi: 10.3390/cells12232749. PMID: 38067176Free PMC Article
Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia.
Sarno J, Domizi P, Liu Y, Merchant M, Pedersen CB, Jedoui D, Jager A, Nolan GP, Gaipa G, Bendall SC, Bava FA, Davis KL
Nat Commun 2023 May 22;14(1):2935. doi: 10.1038/s41467-023-38456-y. PMID: 37217509Free PMC Article
Chronic Stress and Glucocorticoid Receptor Resistance in Asthma.
Palumbo ML, Prochnik A, Wald MR, Genaro AM
Clin Ther 2020 Jun;42(6):993-1006. Epub 2020 Mar 26 doi: 10.1016/j.clinthera.2020.03.002. PMID: 32224031
Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation.
Haarman EG, Kaspers GJ, Veerman AJ
Br J Haematol 2003 Mar;120(6):919-29. doi: 10.1046/j.1365-2141.2003.04189.x. PMID: 12648060
Glucocorticoid-resistant asthma.
Loke TK, Sousa AR, Corrigan CJ, Lee TH
Curr Allergy Asthma Rep 2002 Mar;2(2):144-50. doi: 10.1007/s11882-002-0009-y. PMID: 11892094

Prognosis

Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
Allam VSRR, Pavlidis S, Liu G, Kermani NZ, Simpson J, To J, Donnelly S, Guo YK, Hansbro PM, Phipps S, Morand EF, Djukanovic R, Sterk P, Chung KF, Adcock I, Harris J, Sukkar MB
Thorax 2023 Jul;78(7):661-673. Epub 2022 Nov 7 doi: 10.1136/thorax-2021-218555. PMID: 36344253
Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML
Br J Haematol 2022 Jul;198(1):137-141. Epub 2022 Apr 17 doi: 10.1111/bjh.18181. PMID: 35434798Free PMC Article
Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
Sai S, Esteves C, Kelly V, Sakaguchi K, McAndrew R, Chudleigh S, Spence A, Gibson B, Thomas A, Chapman KE
J Pediatr 2020 May;220:249-253. Epub 2020 Jan 24 doi: 10.1016/j.jpeds.2019.12.054. PMID: 31987650
Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression.
Lambrou GI, Vlahopoulos S, Papathanasiou C, Papanikolaou M, Karpusas M, Zoumakis E, Tzortzatou-Stathopoulou F
Leuk Res 2009 Dec;33(12):1684-95. Epub 2009 May 18 doi: 10.1016/j.leukres.2009.04.018. PMID: 19450877
Glucocorticoid-resistant asthma.
Loke TK, Sousa AR, Corrigan CJ, Lee TH
Curr Allergy Asthma Rep 2002 Mar;2(2):144-50. doi: 10.1007/s11882-002-0009-y. PMID: 11892094

Clinical prediction guides

Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma.
Allam VSRR, Pavlidis S, Liu G, Kermani NZ, Simpson J, To J, Donnelly S, Guo YK, Hansbro PM, Phipps S, Morand EF, Djukanovic R, Sterk P, Chung KF, Adcock I, Harris J, Sukkar MB
Thorax 2023 Jul;78(7):661-673. Epub 2022 Nov 7 doi: 10.1136/thorax-2021-218555. PMID: 36344253
Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
Sai S, Esteves C, Kelly V, Sakaguchi K, McAndrew R, Chudleigh S, Spence A, Gibson B, Thomas A, Chapman KE
J Pediatr 2020 May;220:249-253. Epub 2020 Jan 24 doi: 10.1016/j.jpeds.2019.12.054. PMID: 31987650
The effects of microRNAs on glucocorticoid responsiveness.
Wang H, Gou X, Jiang T, Ouyang J
J Cancer Res Clin Oncol 2017 Jun;143(6):1005-1011. Epub 2017 Mar 12 doi: 10.1007/s00432-017-2388-4. PMID: 28286901
Targeting of the deubiquitinase USP9X attenuates B-cell acute lymphoblastic leukemia cell survival and overcomes glucocorticoid resistance.
Zhou M, Wang T, Lai H, Zhao X, Yu Q, Zhou J, Yang Y
Biochem Biophys Res Commun 2015 Apr 3;459(2):333-339. Epub 2015 Feb 28 doi: 10.1016/j.bbrc.2015.02.115. PMID: 25735983
An emphasis on molecular mechanisms of anti-inflammatory effects and glucocorticoid resistance.
Ingawale DK, Mandlik SK, Patel SS
J Complement Integr Med 2015 Mar;12(1):1-13. doi: 10.1515/jcim-2014-0051. PMID: 25503867

Recent systematic reviews

Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.
Charmandari E, Kino T, Ichijo T, Chrousos GP
J Clin Endocrinol Metab 2008 May;93(5):1563-72. Epub 2008 Mar 4 doi: 10.1210/jc.2008-0040. PMID: 18319312Free PMC Article

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