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Mirror movements 3(MRMV3)

MedGen UID:
863561
•Concept ID:
C4015124
•
Disease or Syndrome
Synonym: MRMV3
 
Gene (location): DNAL4 (22q13.1)
 
Monarch Initiative: MONDO:0014478
OMIM®: 616059

Definition

Any familial congenital mirror movements in which the cause of the disease is a mutation in the DNAL4 gene. [from MONDO]

Clinical features

From HPO
Situs inversus
MedGen UID:
1642262
•Concept ID:
C4551493
•
Congenital Abnormality
A left-right reversal (or mirror reflection) of the anatomical location of the major thoracic and abdominal organs.
See: Feature record | Search on this feature
Bimanual synkinesia
MedGen UID:
473166
•Concept ID:
C0454455
•
Disease or Syndrome
Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Neglect syndrome in post-stroke conditions: assessment and treatment (scoping review).
Tavaszi I, Nagy AS, Szabo G, Fazekas G
Int J Rehabil Res 2021 Mar 1;44(1):3-14. doi: 10.1097/MRR.0000000000000438. PMID: 32991354
The Efficacy of Movement Representation Techniques for Treatment of Limb Pain--A Systematic Review and Meta-Analysis.
Thieme H, Morkisch N, Rietz C, Dohle C, Borgetto B
J Pain 2016 Feb;17(2):167-80. Epub 2015 Nov 6 doi: 10.1016/j.jpain.2015.10.015. PMID: 26552501

Recent clinical studies

Etiology

Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Action observation for upper limb rehabilitation after stroke.
Borges LR, Fernandes AB, Oliveira Dos Passos J, Rego IAO, Campos TF
Cochrane Database Syst Rev 2022 Aug 5;8(8):CD011887. doi: 10.1002/14651858.CD011887.pub3. PMID: 35930301Free PMC Article
Efficacy of mirror therapy and virtual reality therapy in alleviating phantom limb pain: a meta-analysis and systematic review.
Rajendram C, Ken-Dror G, Han T, Sharma P
BMJ Mil Health 2022 Apr;168(2):173-177. Epub 2022 Jan 18 doi: 10.1136/bmjmilitary-2021-002018. PMID: 35042760
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084

Diagnosis

The cerebellar clock: Predicting and timing somatosensory touch.
Andersen LM, Dalal SS
Neuroimage 2021 Sep;238:118202. Epub 2021 Jun 2 doi: 10.1016/j.neuroimage.2021.118202. PMID: 34089874
Transition in endocrinology: induction of puberty.
Dunkel L, Quinton R
Eur J Endocrinol 2014 Jun;170(6):R229-39. Epub 2014 May 17 doi: 10.1530/EJE-13-0894. PMID: 24836550
Repetition priming effects dissociate between miniature eye movements and induced gamma-band responses in the human electroencephalogram.
Hassler U, Friese U, Martens U, Trujillo-Barreto N, Gruber T
Eur J Neurosci 2013 Aug;38(3):2425-33. Epub 2013 May 15 doi: 10.1111/ejn.12244. PMID: 23675819
How does the brain create rhythms?
Szirmai I
Ideggyogy Sz 2010 Jan 30;63(1-2):13-23. PMID: 20420120
Illusory movements of the contralesional hand in patients with body image disorders.
Zampini M, Moro V, Aglioti SM
J Neurol Neurosurg Psychiatry 2004 Nov;75(11):1626-8. doi: 10.1136/jnnp.2003.028589. PMID: 15489402Free PMC Article

Therapy

Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Mirror therapy for unilateral neglect after stroke: A systematic review.
Zhang Y, Xing Y, Li C, Hua Y, Hu J, Wang Y, Ya R, Meng Q, Bai Y
Eur J Neurol 2022 Jan;29(1):358-371. Epub 2021 Oct 5 doi: 10.1111/ene.15122. PMID: 34558762
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
The effects of mirror therapy on pain and motor control of phantom limb in amputees: A systematic review.
Barbin J, Seetha V, Casillas JM, Paysant J, Pérennou D
Ann Phys Rehabil Med 2016 Sep;59(4):270-5. Epub 2016 May 30 doi: 10.1016/j.rehab.2016.04.001. PMID: 27256539

Prognosis

Using mechanistic knowledge to appraise contemporary approaches to the rehabilitation of upper limb function following stroke.
Carson RG, Hayward KS
J Physiol 2025 Feb;603(3):635-650. Epub 2024 Aug 11 doi: 10.1113/JP285559. PMID: 39129269Free PMC Article
Mirror movements and brain pathology in children with unilateral cerebral palsy.
Kuo HC, Ferre CL, Chin KY, Friel KM, Gordon AM
Dev Med Child Neurol 2023 Feb;65(2):264-273. Epub 2022 Jun 24 doi: 10.1111/dmcn.15322. PMID: 35751166
The cerebellar clock: Predicting and timing somatosensory touch.
Andersen LM, Dalal SS
Neuroimage 2021 Sep;238:118202. Epub 2021 Jun 2 doi: 10.1016/j.neuroimage.2021.118202. PMID: 34089874
Callosal agenesis and congenital mirror movements: outcomes associated with DCC mutations.
Spencer-Smith M, Knight JL, Lacaze E; Irc5 Consortium, Depienne C, Lockhart PJ, Richards LJ, Heron D, Leventer RJ, Robinson GA
Dev Med Child Neurol 2020 Jun;62(6):758-762. Epub 2020 Feb 14 doi: 10.1111/dmcn.14486. PMID: 32060908
Effects of intentional movement preparation on response times to symbolic and imitative cues.
Naish KR, Rajagobal A, Galang CM, Sartori L, Obhi SS
Exp Brain Res 2017 Mar;235(3):753-761. Epub 2016 Nov 19 doi: 10.1007/s00221-016-4837-8. PMID: 27866264

Clinical prediction guides

Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial.
Wen X, Li L, Li X, Zha H, Liu Z, Peng Y, Liu X, Liu H, Yang Q, Wang J
Neural Plast 2022;2022:8966920. Epub 2022 Dec 31 doi: 10.1155/2022/8966920. PMID: 36624743Free PMC Article
Action observation for upper limb rehabilitation after stroke.
Borges LR, Fernandes AB, Oliveira Dos Passos J, Rego IAO, Campos TF
Cochrane Database Syst Rev 2022 Aug 5;8(8):CD011887. doi: 10.1002/14651858.CD011887.pub3. PMID: 35930301Free PMC Article
Efficacy of mirror therapy and virtual reality therapy in alleviating phantom limb pain: a meta-analysis and systematic review.
Rajendram C, Ken-Dror G, Han T, Sharma P
BMJ Mil Health 2022 Apr;168(2):173-177. Epub 2022 Jan 18 doi: 10.1136/bmjmilitary-2021-002018. PMID: 35042760
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
Effects of phantom exercises on pain, mobility, and quality of life among lower limb amputees; a randomized controlled trial.
Zaheer A, Malik AN, Masood T, Fatima S
BMC Neurol 2021 Oct 27;21(1):416. doi: 10.1186/s12883-021-02441-z. PMID: 34706654Free PMC Article

Recent systematic reviews

Effect of mirror therapy in the treatment of phantom limb pain in amputees: A systematic review of randomized placebo-controlled trials does not find any evidence of efficacy.
Guémann M, Olié E, Raquin L, Courtet P, Risch N
Eur J Pain 2023 Jan;27(1):3-13. Epub 2022 Sep 19 doi: 10.1002/ejp.2035. PMID: 36094758Free PMC Article
Efficacy of mirror therapy and virtual reality therapy in alleviating phantom limb pain: a meta-analysis and systematic review.
Rajendram C, Ken-Dror G, Han T, Sharma P
BMJ Mil Health 2022 Apr;168(2):173-177. Epub 2022 Jan 18 doi: 10.1136/bmjmilitary-2021-002018. PMID: 35042760
Mirror therapy for unilateral neglect after stroke: A systematic review.
Zhang Y, Xing Y, Li C, Hua Y, Hu J, Wang Y, Ya R, Meng Q, Bai Y
Eur J Neurol 2022 Jan;29(1):358-371. Epub 2021 Oct 5 doi: 10.1111/ene.15122. PMID: 34558762
Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-analysis.
Xie HM, Zhang KX, Wang S, Wang N, Wang N, Li X, Huang LP
Arch Phys Med Rehabil 2022 May;103(5):988-997. Epub 2021 Aug 28 doi: 10.1016/j.apmr.2021.07.810. PMID: 34461084
The effects of mirror therapy on pain and motor control of phantom limb in amputees: A systematic review.
Barbin J, Seetha V, Casillas JM, Paysant J, Pérennou D
Ann Phys Rehabil Med 2016 Sep;59(4):270-5. Epub 2016 May 30 doi: 10.1016/j.rehab.2016.04.001. PMID: 27256539

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