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Fetal and neonatal alloimmune thrombocytopenia

MedGen UID:
1720701
Concept ID:
C3854603
Disease or Syndrome
Synonyms: fetal and neonatal alloimmune thrombocytopenia; FNAIT; NAIT
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019415
Orphanet: ORPHA853

Definition

A rare hematological disease characterized by maternal alloimmunisation against fetal platelet antigens that are inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopenia in otherwise healthy newborns. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal and neonatal alloimmune thrombocytopenia

Professional guidelines

PubMed

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Petermann R, Bakchoul T, Curtis BR, Mullier F, Miyata S, Arnold DM; Subcommittee on Platelet Immunology
J Thromb Haemost 2018 Dec;16(12):2526-2529. Epub 2018 Nov 1 doi: 10.1111/jth.14294. PMID: 30382606

Recent clinical studies

Etiology

Stam W, Wachholz GE, de Pereda JM, Kapur R, van der Schoot E, Margadant C
Blood Rev 2023 May;59:101038. Epub 2022 Dec 22 doi: 10.1016/j.blre.2022.101038. PMID: 36581513
Barg A, Bonstein L
Semin Thromb Hemost 2023 Jun;49(4):402-408. Epub 2022 Nov 11 doi: 10.1055/s-0042-1757900. PMID: 36368687
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Zdravic D, Yougbare I, Vadasz B, Li C, Marshall AH, Chen P, Kjeldsen-Kragh J, Ni H
Semin Fetal Neonatal Med 2016 Feb;21(1):19-27. Epub 2016 Jan 20 doi: 10.1016/j.siny.2015.12.004. PMID: 26810319

Diagnosis

Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Petermann R, Bakchoul T, Curtis BR, Mullier F, Miyata S, Arnold DM; Subcommittee on Platelet Immunology
J Thromb Haemost 2018 Dec;16(12):2526-2529. Epub 2018 Nov 1 doi: 10.1111/jth.14294. PMID: 30382606
Kaplan C, Forestier F, Daffos F, Tchernia G, Waters A
Transfus Med Rev 1996 Jul;10(3):233-40. doi: 10.1016/s0887-7963(96)80062-9. PMID: 8809972

Therapy

Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Baker JM, Shehata N, Bussel J, Murphy MF, Greinacher A, Bakchoul T, Massey E, Lieberman L, Landry D, Tanael S, Arnold DM, Baidya S, Bertrand G, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Savoia H, Ryan G, Hume H; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
J Perinatol 2019 Oct;39(10):1329-1339. Epub 2019 Apr 10 doi: 10.1038/s41372-019-0360-7. PMID: 30971767
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Oepkes D, Lopriore E
Expert Rev Hematol 2017 Aug;10(8):729-737. Epub 2017 Jun 29 doi: 10.1080/17474086.2017.1346471. PMID: 28644735
Kaplan C, Daffos F, Forestier F, Morel-Kopp MC, Tchernia G
Vox Sang 1994;67 Suppl 3:85-8. doi: 10.1111/j.1423-0410.1994.tb04550.x. PMID: 7975518

Prognosis

Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
de Vos TW, Winkelhorst D, Árnadóttir V, van der Bom JG, Canals Surís C, Caram-Deelder C, Deschmann E, Haysom HE, Hverven HBC, Lozar Krivec J, McQuilten ZK, Muñiz-Diaz E, Nogués N, Oepkes D, Porcelijn L, van der Schoot CE, Saxonhouse M, Sola-Visner M, Tiblad E, Tiller H, Wood EM, Young V, Železnik M, de Haas M, Lopriore E
Lancet Haematol 2022 Nov;9(11):e844-e853. Epub 2022 Sep 12 doi: 10.1016/S2352-3026(22)00243-5. PMID: 36108655
Petermann R, Bakchoul T, Curtis BR, Mullier F, Miyata S, Arnold DM; Subcommittee on Platelet Immunology
J Thromb Haemost 2018 Dec;16(12):2526-2529. Epub 2018 Nov 1 doi: 10.1111/jth.14294. PMID: 30382606
Symington A, Paes B
Am J Perinatol 2011 Feb;28(2):137-44. Epub 2010 Aug 10 doi: 10.1055/s-0030-1263296. PMID: 20700860
Porcelijn L, Van den Akker ES, Oepkes D
Semin Fetal Neonatal Med 2008 Aug;13(4):223-30. Epub 2008 Apr 8 doi: 10.1016/j.siny.2008.02.008. PMID: 18400574

Clinical prediction guides

de Vos TW, Winkelhorst D, Porcelijn L, Beaufort M, Oldert G, van der Bom JG, Lopriore E, Oepkes D, de Haas M, van der Schoot E
Lancet Haematol 2023 Dec;10(12):e985-e993. Epub 2023 Oct 27 doi: 10.1016/S2352-3026(23)00271-5. PMID: 38407610
de Vos TW, van Zagten M, de Haas M, Oepkes D, Tan RNGB, van der Schoot CE, Steggerda SJ, de Vries LS, Lopriore E, van Klink JMM
J Pediatr 2023 Jul;258:113385. Epub 2023 Mar 16 doi: 10.1016/j.jpeds.2023.02.031. PMID: 36933767
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
de Vos TW, Winkelhorst D, Baelde HJ, Dijkstra KL, van Bergen RDM, van der Meeren LE, Nikkels PGJ, Porcelijn L, van der Schoot CE, Vidarsson G, Eikmans M, Kapur R, van der Keur C, Trouw LA, Oepkes D, Lopriore E, van der Hoorn MP, Bos M, de Haas M
Int J Mol Sci 2021 Jun 23;22(13) doi: 10.3390/ijms22136763. PMID: 34201864Free PMC Article
Petermann R, Bakchoul T, Curtis BR, Mullier F, Miyata S, Arnold DM; Subcommittee on Platelet Immunology
J Thromb Haemost 2018 Dec;16(12):2526-2529. Epub 2018 Nov 1 doi: 10.1111/jth.14294. PMID: 30382606

Recent systematic reviews

Kjeldsen-Kragh J, Fergusson DA, Kjaer M, Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia HF, Landry D, Shehata N
Blood Adv 2020 Jul 28;4(14):3368-3377. doi: 10.1182/bloodadvances.2020002137. PMID: 32717028Free PMC Article
Baker JM, Shehata N, Bussel J, Murphy MF, Greinacher A, Bakchoul T, Massey E, Lieberman L, Landry D, Tanael S, Arnold DM, Baidya S, Bertrand G, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Savoia H, Ryan G, Hume H; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
J Perinatol 2019 Oct;39(10):1329-1339. Epub 2019 Apr 10 doi: 10.1038/s41372-019-0360-7. PMID: 30971767
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G
Blood 2017 Mar 16;129(11):1538-1547. Epub 2017 Jan 27 doi: 10.1182/blood-2016-10-739656. PMID: 28130210
Kamphuis MM, Paridaans N, Porcelijn L, De Haas M, Van Der Schoot CE, Brand A, Bonsel GJ, Oepkes D
BJOG 2010 Oct;117(11):1335-43. doi: 10.1111/j.1471-0528.2010.02657.x. PMID: 20618318

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