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Diabetes mellitus, type 1, susceptibility to

MedGen UID:
854228
•Concept ID:
C3837968
•
Finding
Synonym: DIABETES MELLITUS, TYPE 1, SUSCEPTIBILITY TO
 
OMIM®: 147620

Professional guidelines

PubMed

ABO Blood Group Genotypes and Demographic Traits in Susceptibility to Type 1 Diabetes Mellitus in Lagos, Southwest, Nigeria.
Yahaya T, Abdullahi H, Muhammad Z, Ibrahim Y, Abdullahi M, Ribah S, Jimoh M
Niger J Physiol Sci 2023 Feb 5;37(2):199-205. doi: 10.54548/njps.v37i2.6. PMID: 38243561
Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs.
Haider MZ, Rasoul MA, Al-Mahdi M, Al-Kandari H, Dhaunsi GS
PLoS One 2018;13(6):e0198652. Epub 2018 Jun 20 doi: 10.1371/journal.pone.0198652. PMID: 29924845Free PMC Article

Recent clinical studies

Etiology

Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.
Yuan S, Merino J, Larsson SC
Diabetologia 2023 May;66(5):800-812. Epub 2023 Feb 14 doi: 10.1007/s00125-023-05879-7. PMID: 36786839Free PMC Article
Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS
Lancet Diabetes Endocrinol 2022 Aug;10(8):597-608. Epub 2022 Jun 17 doi: 10.1016/S2213-8587(22)00159-0. PMID: 35724677Free PMC Article
Genetic overlap between type 1 diabetes and other autoimmune diseases.
Márquez A, Martín J
Semin Immunopathol 2022 Jan;44(1):81-97. Epub 2021 Oct 1 doi: 10.1007/s00281-021-00885-6. PMID: 34595540
Prediction and Prevention of Type 1 Diabetes.
Primavera M, Giannini C, Chiarelli F
Front Endocrinol (Lausanne) 2020;11:248. Epub 2020 Jun 2 doi: 10.3389/fendo.2020.00248. PMID: 32670194Free PMC Article
Understanding type 1 diabetes through genetics: advances and prospects.
Polychronakos C, Li Q
Nat Rev Genet 2011 Oct 18;12(11):781-92. doi: 10.1038/nrg3069. PMID: 22005987

Diagnosis

Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS
Lancet Diabetes Endocrinol 2022 Aug;10(8):597-608. Epub 2022 Jun 17 doi: 10.1016/S2213-8587(22)00159-0. PMID: 35724677Free PMC Article
Pathogenesis of Type 1 Diabetes: Established Facts and New Insights.
Zajec A, Trebušak Podkrajšek K, Tesovnik T, Šket R, Čugalj Kern B, Jenko Bizjan B, Šmigoc Schweiger D, Battelino T, Kovač J
Genes (Basel) 2022 Apr 16;13(4) doi: 10.3390/genes13040706. PMID: 35456512Free PMC Article
Prediction and Prevention of Type 1 Diabetes.
Primavera M, Giannini C, Chiarelli F
Front Endocrinol (Lausanne) 2020;11:248. Epub 2020 Jun 2 doi: 10.3389/fendo.2020.00248. PMID: 32670194Free PMC Article
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, Skyler JS, Sosenko JM, Ziegler AG
Diabetes Care 2015 Oct;38(10):1964-74. doi: 10.2337/dc15-1419. PMID: 26404926Free PMC Article
Type 1 diabetes: etiology, immunology, and therapeutic strategies.
van Belle TL, Coppieters KT, von Herrath MG
Physiol Rev 2011 Jan;91(1):79-118. doi: 10.1152/physrev.00003.2010. PMID: 21248163

Therapy

Type 1 diabetes mellitus: much progress, many opportunities.
Powers AC
J Clin Invest 2021 Apr 15;131(8) doi: 10.1172/JCI142242. PMID: 33759815Free PMC Article
The heterogeneous pathogenesis of type 1 diabetes mellitus.
Ilonen J, Lempainen J, Veijola R
Nat Rev Endocrinol 2019 Nov;15(11):635-650. Epub 2019 Sep 18 doi: 10.1038/s41574-019-0254-y. PMID: 31534209
Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review.
de Filette JMK, Pen JJ, Decoster L, Vissers T, Bravenboer B, Van der Auwera BJ, Gorus FK, Roep BO, Aspeslagh S, Neyns B, Velkeniers B, Kharagjitsingh AV
Eur J Endocrinol 2019 Sep;181(3):363-374. doi: 10.1530/EJE-19-0291. PMID: 31330498Free PMC Article
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q
Sci Transl Med 2015 Nov 25;7(315):315ra189. doi: 10.1126/scitranslmed.aad4134. PMID: 26606968Free PMC Article
Type 1 diabetes: etiology, immunology, and therapeutic strategies.
van Belle TL, Coppieters KT, von Herrath MG
Physiol Rev 2011 Jan;91(1):79-118. doi: 10.1152/physrev.00003.2010. PMID: 21248163

Prognosis

Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS
Lancet Diabetes Endocrinol 2022 Aug;10(8):597-608. Epub 2022 Jun 17 doi: 10.1016/S2213-8587(22)00159-0. PMID: 35724677Free PMC Article
Pathogenesis of Type 1 Diabetes: Established Facts and New Insights.
Zajec A, Trebušak Podkrajšek K, Tesovnik T, Šket R, Čugalj Kern B, Jenko Bizjan B, Šmigoc Schweiger D, Battelino T, Kovač J
Genes (Basel) 2022 Apr 16;13(4) doi: 10.3390/genes13040706. PMID: 35456512Free PMC Article
Prediction and Prevention of Type 1 Diabetes.
Primavera M, Giannini C, Chiarelli F
Front Endocrinol (Lausanne) 2020;11:248. Epub 2020 Jun 2 doi: 10.3389/fendo.2020.00248. PMID: 32670194Free PMC Article
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.
Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, Skyler JS, Sosenko JM, Ziegler AG
Diabetes Care 2015 Oct;38(10):1964-74. doi: 10.2337/dc15-1419. PMID: 26404926Free PMC Article
Type 1 diabetes: new perspectives on disease pathogenesis and treatment.
Atkinson MA, Eisenbarth GS
Lancet 2001 Jul 21;358(9277):221-9. doi: 10.1016/S0140-6736(01)05415-0. PMID: 11476858

Clinical prediction guides

Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.
Yuan S, Merino J, Larsson SC
Diabetologia 2023 May;66(5):800-812. Epub 2023 Feb 14 doi: 10.1007/s00125-023-05879-7. PMID: 36786839Free PMC Article
Type 1 diabetes in diverse ancestries and the use of genetic risk scores.
Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS
Lancet Diabetes Endocrinol 2022 Aug;10(8):597-608. Epub 2022 Jun 17 doi: 10.1016/S2213-8587(22)00159-0. PMID: 35724677Free PMC Article
Pathogenesis of Type 1 Diabetes: Established Facts and New Insights.
Zajec A, Trebušak Podkrajšek K, Tesovnik T, Šket R, Čugalj Kern B, Jenko Bizjan B, Šmigoc Schweiger D, Battelino T, Kovač J
Genes (Basel) 2022 Apr 16;13(4) doi: 10.3390/genes13040706. PMID: 35456512Free PMC Article
Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes.
Skol AD, Jung SC, Sokovic AM, Chen S, Fazal S, Sosina O, Borkar PP, Lin A, Sverdlov M, Cao D, Swaroop A, Bebu I; DCCT/EDIC Study group, Stranger BE, Grassi MA
Elife 2020 Nov 9;9 doi: 10.7554/eLife.59980. PMID: 33164750Free PMC Article
Prediction and Prevention of Type 1 Diabetes.
Primavera M, Giannini C, Chiarelli F
Front Endocrinol (Lausanne) 2020;11:248. Epub 2020 Jun 2 doi: 10.3389/fendo.2020.00248. PMID: 32670194Free PMC Article

Recent systematic reviews

Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence.
Najjar L, Sutherland J, Zhou A, Hyppönen E
Nutrients 2021 Nov 26;13(12) doi: 10.3390/nu13124260. PMID: 34959812Free PMC Article
Association Between Enterovirus Infection and Type 1 Diabetes Risk: A Meta-Analysis of 38 Case-Control Studies.
Wang K, Ye F, Chen Y, Xu J, Zhao Y, Wang Y, Lan T
Front Endocrinol (Lausanne) 2021;12:706964. Epub 2021 Sep 7 doi: 10.3389/fendo.2021.706964. PMID: 34557158Free PMC Article
Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.
Padilla-Martínez F, Collin F, Kwasniewski M, Kretowski A
Int J Mol Sci 2020 Mar 2;21(5) doi: 10.3390/ijms21051703. PMID: 32131491Free PMC Article
Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review.
de Filette JMK, Pen JJ, Decoster L, Vissers T, Bravenboer B, Van der Auwera BJ, Gorus FK, Roep BO, Aspeslagh S, Neyns B, Velkeniers B, Kharagjitsingh AV
Eur J Endocrinol 2019 Sep;181(3):363-374. doi: 10.1530/EJE-19-0291. PMID: 31330498Free PMC Article
Contribution of VDR polymorphisms to type 1 diabetes susceptibility: Systematic review of case-control studies and meta-analysis.
Tizaoui K, Kaabachi W, Hamzaoui A, Hamzaoui K
J Steroid Biochem Mol Biol 2014 Sep;143:240-9. Epub 2014 Apr 15 doi: 10.1016/j.jsbmb.2014.03.011. PMID: 24742873

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