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Alzheimer disease 18(AD18)

MedGen UID:
816371
•Concept ID:
C3810041
•
Disease or Syndrome
Synonyms: AD18; ALZHEIMER DISEASE 18, LATE-ONSET; ALZHEIMER DISEASE 18, SUSCEPTIBILITY TO
 
Gene (location): ADAM10 (15q21.3)
 
Monarch Initiative: MONDO:0014265
OMIM®: 615590

Definition

Any Alzheimer disease in which the cause of the disease is a mutation in the ADAM10 gene. [from MONDO]

Professional guidelines

PubMed

Treatment of Alzheimer's Disease: Beyond Symptomatic Therapies.
Buccellato FR, D'Anca M, Tartaglia GM, Del Fabbro M, Scarpini E, Galimberti D
Int J Mol Sci 2023 Sep 9;24(18) doi: 10.3390/ijms241813900. PMID: 37762203Free PMC Article
The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease.
Khan S, Barve KH, Kumar MS
Curr Neuropharmacol 2020;18(11):1106-1125. doi: 10.2174/1570159X18666200528142429. PMID: 32484110Free PMC Article

Recent clinical studies

Etiology

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
2023 Alzheimer's disease facts and figures.
Alzheimers Dement 2023 Apr;19(4):1598-1695. Epub 2023 Mar 14 doi: 10.1002/alz.13016. PMID: 36918389
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
Alzheimer's disease: early diagnosis and treatment.
Chu LW
Hong Kong Med J 2012 Jun;18(3):228-37. PMID: 22665688

Diagnosis

Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
2023 Alzheimer's disease facts and figures.
Alzheimers Dement 2023 Apr;19(4):1598-1695. Epub 2023 Mar 14 doi: 10.1002/alz.13016. PMID: 36918389
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease.
Khan S, Barve KH, Kumar MS
Curr Neuropharmacol 2020;18(11):1106-1125. doi: 10.2174/1570159X18666200528142429. PMID: 32484110Free PMC Article
Alzheimer disease.
Cummings JL, Cole G
JAMA 2002 May 8;287(18):2335-8. doi: 10.1001/jama.287.18.2335. PMID: 11988038

Therapy

Lecanemab (Leqembi) is not the right drug for patients with Alzheimer's disease.
Kurkinen M
Adv Clin Exp Med 2023 Sep;32(9):943-947. doi: 10.17219/acem/171379. PMID: 37676096
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study.
McDade E, Cummings JL, Dhadda S, Swanson CJ, Reyderman L, Kanekiyo M, Koyama A, Irizarry M, Kramer LD, Bateman RJ
Alzheimers Res Ther 2022 Dec 21;14(1):191. doi: 10.1186/s13195-022-01124-2. PMID: 36544184Free PMC Article
Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease.
Athar T, Al Balushi K, Khan SA
Mol Biol Rep 2021 Jul;48(7):5629-5645. Epub 2021 Jun 28 doi: 10.1007/s11033-021-06512-9. PMID: 34181171Free PMC Article
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody.
Swanson CJ, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai RYK, Lannfelt L, Bradley H, Rabe M, Koyama A, Reyderman L, Berry DA, Berry S, Gordon R, Kramer LD, Cummings JL
Alzheimers Res Ther 2021 Apr 17;13(1):80. doi: 10.1186/s13195-021-00813-8. PMID: 33865446Free PMC Article

Prognosis

Alzheimer's disease mortality among taxi and ambulance drivers: population based cross sectional study.
R Patel V, Liu M, Worsham CM, Jena AB
BMJ 2024 Dec 17;387:e082194. doi: 10.1136/bmj-2024-082194. PMID: 39689964Free PMC Article
2024 Alzheimer's disease facts and figures.
Alzheimers Dement 2024 May;20(5):3708-3821. Epub 2024 Apr 30 doi: 10.1002/alz.13809. PMID: 38689398Free PMC Article
Biomarker Changes during 20 Years Preceding Alzheimer's Disease.
Jia J, Ning Y, Chen M, Wang S, Yang H, Li F, Ding J, Li Y, Zhao B, Lyu J, Yang S, Yan X, Wang Y, Qin W, Wang Q, Li Y, Zhang J, Liang F, Liao Z, Wang S
N Engl J Med 2024 Feb 22;390(8):712-722. doi: 10.1056/NEJMoa2310168. PMID: 38381674
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.
Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, Szoeke C, Macaulay SL, Martins R, Maruff P, Ames D, Rowe CC, Masters CL; Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Lancet Neurol 2013 Apr;12(4):357-67. Epub 2013 Mar 8 doi: 10.1016/S1474-4422(13)70044-9. PMID: 23477989
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census.
Hebert LE, Weuve J, Scherr PA, Evans DA
Neurology 2013 May 7;80(19):1778-83. Epub 2013 Feb 6 doi: 10.1212/WNL.0b013e31828726f5. PMID: 23390181Free PMC Article

Clinical prediction guides

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J, Wessels AM, Shcherbinin S, Wang H, Monkul Nery ES, Collins EC, Solomon P, Salloway S, Apostolova LG, Hansson O, Ritchie C, Brooks DA, Mintun M, Skovronsky DM; TRAILBLAZER-ALZ 2 Investigators
JAMA 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239. PMID: 37459141Free PMC Article
PET Imaging of Neuroinflammation in Alzheimer's Disease.
Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R
Front Immunol 2021;12:739130. Epub 2021 Sep 16 doi: 10.3389/fimmu.2021.739130. PMID: 34603323Free PMC Article
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody.
Swanson CJ, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai RYK, Lannfelt L, Bradley H, Rabe M, Koyama A, Reyderman L, Berry DA, Berry S, Gordon R, Kramer LD, Cummings JL
Alzheimers Res Ther 2021 Apr 17;13(1):80. doi: 10.1186/s13195-021-00813-8. PMID: 33865446Free PMC Article
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease.
Khan S, Barve KH, Kumar MS
Curr Neuropharmacol 2020;18(11):1106-1125. doi: 10.2174/1570159X18666200528142429. PMID: 32484110Free PMC Article
Physiotherapy intervention in Alzheimer's disease: systematic review and meta-analysis.
Zhu XC, Yu Y, Wang HF, Jiang T, Cao L, Wang C, Wang J, Tan CC, Meng XF, Tan L, Yu JT
J Alzheimers Dis 2015;44(1):163-74. doi: 10.3233/JAD-141377. PMID: 25201787

Recent systematic reviews

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review.
Borsa L, Dubois M, Sacco G, Lupi L
Int J Environ Res Public Health 2021 Sep 3;18(17) doi: 10.3390/ijerph18179312. PMID: 34501899Free PMC Article
Menopausal hormone therapy and women's health: An umbrella review.
Zhang GQ, Chen JL, Luo Y, Mathur MB, Anagnostis P, Nurmatov U, Talibov M, Zhang J, Hawrylowicz CM, Lumsden MA, Critchley H, Sheikh A, Lundbäck B, Lässer C, Kankaanranta H, Lee SH, Nwaru BI
PLoS Med 2021 Aug;18(8):e1003731. Epub 2021 Aug 2 doi: 10.1371/journal.pmed.1003731. PMID: 34339416Free PMC Article
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
The Prevalence of Dementia: A Systematic Review and Meta-Analysis.
Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, Tan L, Yu JT
J Alzheimers Dis 2020;73(3):1157-1166. doi: 10.3233/JAD-191092. PMID: 31884487

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      Related information in NCBI Gene
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      Related information in GTR
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      Clinical tests in GTR
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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