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Multiple fibroadenoma of the breast(MFAB)

MedGen UID:
816248
•Concept ID:
C3809918
•
Neoplastic Process
Synonym: Multiple fibroadenomas of the breast
SNOMED CT: Multiple fibroadenomas of breast (721601007)
 
Gene (location): PRLR (5p13.2)
 
Monarch Initiative: MONDO:0014249
OMIM®: 615554

Definition

Fibroadenoma represents a benign breast disease characterized by lobuloalveolar growth with abnormally high proliferation of the epithelium. Patients with more than 3 fibroadenomas in 1 breast are considered to have multiple fibroadenomas (summary by Bogorad et al., 2008). [from OMIM]

Clinical features

From HPO
Fibroadenoma of the breast
MedGen UID:
64231
•Concept ID:
C0178421
•
Neoplastic Process
A benign biphasic tumor of the breast with epithelial and stromal components.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
MRI-guided treatment in the breast.
Pediconi F, Marzocca F, Cavallo Marincola B, Napoli A
J Magn Reson Imaging 2018 Dec;48(6):1479-1488. Epub 2018 Oct 14 doi: 10.1002/jmri.26282. PMID: 30318672
Clinical and radiologic data and core needle biopsy findings should dictate management of cellular fibroepithelial tumors of the breast.
Resetkova E, Khazai L, Albarracin CT, Arribas E
Breast J 2010 Nov-Dec;16(6):573-80. doi: 10.1111/j.1524-4741.2010.01013.x. PMID: 21070433

Recent clinical studies

Etiology

Native T1 mapping of the breast in MRI to differentiate fibroadenomas from benign phyllodes tumors: a preliminary study.
Yalcin A, Goktepeli M, Taydas O, Sayar I
MAGMA 2022 Jun;35(3):441-447. Epub 2021 Nov 2 doi: 10.1007/s10334-021-00969-2. PMID: 34727247
Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Low-grade adenosquamous carcinoma of the breast: A diagnostic and clinical challenge.
Tan QT, Chuwa EW, Chew SH, Lim-Tan SK, Lim SH
Int J Surg 2015 Jul;19:22-6. Epub 2015 May 15 doi: 10.1016/j.ijsu.2015.05.010. PMID: 25986061

Diagnosis

Refining the classification of breast phyllodes tumours.
Tan PH
Pathology 2023 Jun;55(4):437-448. Epub 2023 Mar 21 doi: 10.1016/j.pathol.2023.02.001. PMID: 37085395
MRI-guided treatment in the breast.
Pediconi F, Marzocca F, Cavallo Marincola B, Napoli A
J Magn Reson Imaging 2018 Dec;48(6):1479-1488. Epub 2018 Oct 14 doi: 10.1002/jmri.26282. PMID: 30318672
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Magnetic resonance imaging of the breast.
El Khouli RH, Jacobs MA, Bluemke DA
Semin Roentgenol 2008 Oct;43(4):265-81. doi: 10.1053/j.ro.2008.07.002. PMID: 18774031

Therapy

Electrical impedance spectroscopy of the breast: clinical imaging results in 26 subjects.
Kerner TE, Paulsen KD, Hartov A, Soho SK, Poplack SP
IEEE Trans Med Imaging 2002 Jun;21(6):638-45. doi: 10.1109/tmi.2002.800606. PMID: 12166860
The nature of tamoxifen action in the control of female breast cancer.
Kodama M, Kodama T
In Vivo 2001 Jul-Aug;15(4):319-25. PMID: 11695224
Cyclosporin A and multiple fibroadenomas of the breast.
Baildam AD, Higgins RM, Hurley E, Furlong A, Walls J, Venning MC, Ackrill P, Mansel RE
Br J Surg 1996 Dec;83(12):1755-7. doi: 10.1002/bjs.1800831229. PMID: 9038560
Fibrocystic disease of the breast.
Greenblatt RB, Samaras C, Vasquez JM, Nezhat C
Clin Obstet Gynecol 1982 Jun;25(2):365-71. doi: 10.1097/00003081-198206000-00019. PMID: 7105513
Fibroadenoma of the female breast. Some epidemiologic surprises.
Nigro DM, Organ CH Jr
Postgrad Med 1976 May;59(5):113-7. doi: 10.1080/00325481.1976.11714358. PMID: 177964

Prognosis

Refining the classification of breast phyllodes tumours.
Tan PH
Pathology 2023 Jun;55(4):437-448. Epub 2023 Mar 21 doi: 10.1016/j.pathol.2023.02.001. PMID: 37085395
Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Clinical prediction guides

Juvenile Papillomatosis of the Breast: a Report of Two Cases with Review of the literature.
Al-Qurashi M, Ibrahim A, ElSharkawy TM, Al Nemer A, Alhaddad H, Hadi MA
Med Arch 2024;78(2):170-173. doi: 10.5455/medarh.2024.78.170-173. PMID: 38566878Free PMC Article
Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk.
Chakhtoura Z, Laki F, Bernadet M, Cherifi I, Chiche A, Pigat N, Bernichtein S, Courtillot C, Boutillon F, Bièche I, Vacher S, Tanguy ML, Bissery A, Grouthier V, Camparo P, Foretz M, Do Cruzeiro M, Pierre R, Rakotozafy F, Tichet J, Tejedor I, Guidotti JE, Sigal-Zafrani B, Goffin V, Touraine P
J Clin Endocrinol Metab 2016 Nov;101(11):4449-4460. Epub 2016 Aug 30 doi: 10.1210/jc.2016-2372. PMID: 27575941
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

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