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Anti-D isoimmunization affecting pregnancy

MedGen UID:
785612
•Concept ID:
C3698348
•
Disease or Syndrome
SNOMED CT: Anti-D isoimmunization affecting pregnancy (699950009)

Professional guidelines

PubMed

RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Management of anti-Rhesus-D antibodies in pregnancy: a review from 1994 to 1998.
Cheong YC, Goodrick J, Kyle PM, Soothill P
Fetal Diagn Ther 2001 Sep-Oct;16(5):294-8. doi: 10.1159/000053931. PMID: 11509852
Management of neonatal Rh disease.
Peterec SM
Clin Perinatol 1995 Sep;22(3):561-92. PMID: 8521682

Recent clinical studies

Etiology

RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Red blood cell alloimmunisation after platelet transfusion (excluding ABO blood group system).
Moncharmont P
Transfus Clin Biol 2020 Aug;27(3):185-190. Epub 2020 Jun 13 doi: 10.1016/j.tracli.2020.06.001. PMID: 32544526
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2002 Sep;100(3):600-11. doi: 10.1016/s0029-7844(02)02180-4. PMID: 12220785
Intravenous immune globulin in the management of severe Rh D hemolytic disease.
Porter TF, Silver RM, Jackson GM, Branch DW, Scott JR
Obstet Gynecol Surv 1997 Mar;52(3):193-7. doi: 10.1097/00006254-199703000-00022. PMID: 9061721
Management of neonatal Rh disease.
Peterec SM
Clin Perinatol 1995 Sep;22(3):561-92. PMID: 8521682

Diagnosis

RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Rhesus D alloimmunization in pregnancy from 1996 to 2015 in Iceland: a nation-wide population study prior to routine antenatal anti-D prophylaxis.
Gudlaugsson B, Hjartardottir H, Svansdottir G, Gudmundsdottir G, Kjartansson S, Jonsson T, Gudmundsson S, Halldorsdottir AM
Transfusion 2020 Jan;60(1):175-183. Epub 2019 Dec 18 doi: 10.1111/trf.15635. PMID: 31850521
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2008 Jul;112(1):164-76. doi: 10.1097/AOG.0b013e31817d453c. PMID: 18591322
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2002 Sep;100(3):600-11. doi: 10.1016/s0029-7844(02)02180-4. PMID: 12220785
Management of neonatal Rh disease.
Peterec SM
Clin Perinatol 1995 Sep;22(3):561-92. PMID: 8521682

Therapy

RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Red blood cell alloimmunisation after platelet transfusion (excluding ABO blood group system).
Moncharmont P
Transfus Clin Biol 2020 Aug;27(3):185-190. Epub 2020 Jun 13 doi: 10.1016/j.tracli.2020.06.001. PMID: 32544526
Anti-D administration in pregnancy for preventing rhesus alloimmunisation.
Crowther CA, Keirse MJ
Cochrane Database Syst Rev 2000;(2):CD000020. doi: 10.1002/14651858.CD000020. PMID: 10796088
Intravenous immune globulin in the management of severe Rh D hemolytic disease.
Porter TF, Silver RM, Jackson GM, Branch DW, Scott JR
Obstet Gynecol Surv 1997 Mar;52(3):193-7. doi: 10.1097/00006254-199703000-00022. PMID: 9061721
Management of neonatal Rh disease.
Peterec SM
Clin Perinatol 1995 Sep;22(3):561-92. PMID: 8521682

Prognosis

How clinically important are non-D Rh antibodies?
Healsmith S, Savoia H, Kane SC
Acta Obstet Gynecol Scand 2019 Jul;98(7):877-884. Epub 2019 Feb 24 doi: 10.1111/aogs.13555. PMID: 30723901
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2008 Jul;112(1):164-76. doi: 10.1097/AOG.0b013e31817d453c. PMID: 18591322
Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2002 Sep;100(3):600-11. doi: 10.1016/s0029-7844(02)02180-4. PMID: 12220785
Management of anti-Rhesus-D antibodies in pregnancy: a review from 1994 to 1998.
Cheong YC, Goodrick J, Kyle PM, Soothill P
Fetal Diagn Ther 2001 Sep-Oct;16(5):294-8. doi: 10.1159/000053931. PMID: 11509852
A comparison of in vitro tests for predicting the severity of haemolytic disease of the fetus and newborn.
Hadley AG
Vox Sang 1998;74 Suppl 2:375-83. doi: 10.1111/j.1423-0410.1998.tb05445.x. PMID: 9704470

Clinical prediction guides

Management of rhesus alloimmunization in pregnancy.
Moise KJ Jr
Obstet Gynecol 2008 Jul;112(1):164-76. doi: 10.1097/AOG.0b013e31817d453c. PMID: 18591322
Anti-D administration in pregnancy for preventing rhesus alloimmunisation.
Crowther CA, Keirse MJ
Cochrane Database Syst Rev 2000;(2):CD000020. doi: 10.1002/14651858.CD000020. PMID: 10796088
A comparison of in vitro tests for predicting the severity of haemolytic disease of the fetus and newborn.
Hadley AG
Vox Sang 1998;74 Suppl 2:375-83. doi: 10.1111/j.1423-0410.1998.tb05445.x. PMID: 9704470
Concentration of anti-D antibodies in Rh(D) alloimmunized pregnant women, as a predictor of anemia and/or hyperbilirubinemia in their newborn infants.
Gottvall T, Hildén JO
Acta Obstet Gynecol Scand 1997 Sep;76(8):733-8. doi: 10.3109/00016349709024338. PMID: 9348249
Severe Rh(D) immunization: anti-D quantitation and treatment possibilities during pregnancy and after birth.
Gottvall T, Hildén JO, Nelson N, Filbey D
Acta Paediatr 1995 Nov;84(11):1315-7. doi: 10.1111/j.1651-2227.1995.tb13557.x. PMID: 8580635

Recent systematic reviews

Anti-D administration in pregnancy for preventing rhesus alloimmunisation.
Crowther CA, Keirse MJ
Cochrane Database Syst Rev 2000;(2):CD000020. doi: 10.1002/14651858.CD000020. PMID: 10796088

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