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Mononeuropathy of the Median Nerve

MedGen UID:
461947
•Concept ID:
C3150597
•
Finding
Synonym: Mononeuropathy of the median nerve

Professional guidelines

PubMed

Pathophysiology, Diagnosis, Treatment, and Genetics of Carpal Tunnel Syndrome: A Review.
Malakootian M, Soveizi M, Gholipour A, Oveisee M
Cell Mol Neurobiol 2023 Jul;43(5):1817-1831. Epub 2022 Oct 10 doi: 10.1007/s10571-022-01297-2. PMID: 36217059Free PMC Article
Guiding Treatment for Carpal Tunnel Syndrome.
Wang L
Phys Med Rehabil Clin N Am 2018 Nov;29(4):751-760. Epub 2018 Sep 17 doi: 10.1016/j.pmr.2018.06.009. PMID: 30293628
Carpal Tunnel Syndrome: Diagnosis and Management.
Wipperman J, Goerl K
Am Fam Physician 2016 Dec 15;94(12):993-999. PMID: 28075090

Recent clinical studies

Etiology

Comparative Efficacy of Routine Physical Therapy with and without Neuromobilization in the Treatment of Patients with Mild to Moderate Carpal Tunnel Syndrome.
Ijaz MJ, Karimi H, Ahmad A, Gillani SA, Anwar N, Chaudhary MA
Biomed Res Int 2022;2022:2155765. Epub 2022 Jun 22 doi: 10.1155/2022/2155765. PMID: 35782066Free PMC Article
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Pathophysiology of carpal tunnel syndrome.
Aboonq MS
Neurosciences (Riyadh) 2015 Jan;20(1):4-9. PMID: 25630774Free PMC Article
Do 'sliders' slide and 'tensioners' tension? An analysis of neurodynamic techniques and considerations regarding their application.
Coppieters MW, Butler DS
Man Ther 2008 Jun;13(3):213-21. Epub 2007 Mar 30 doi: 10.1016/j.math.2006.12.008. PMID: 17398140
A neurophysiological grading scale for carpal tunnel syndrome.
Bland JD
Muscle Nerve 2000 Aug;23(8):1280-3. doi: 10.1002/1097-4598(200008)23:8<1280::aid-mus20>3.0.co;2-y. PMID: 10918269

Diagnosis

Other median neuropathies.
Richards D, Levin KH
Handb Clin Neurol 2024;201:89-101. doi: 10.1016/B978-0-323-90108-6.00011-9. PMID: 38697748
Carpal tunnel sonography.
Gervasio A, Stelitano C, Bollani P, Giardini A, Vanzetti E, Ferrari M
J Ultrasound 2020 Sep;23(3):337-347. Epub 2020 Apr 22 doi: 10.1007/s40477-020-00460-z. PMID: 32323256Free PMC Article
Carpal Tunnel Syndrome: An Update for the Primary Care Physician.
Wright AR, Atkinson RE
Hawaii J Health Soc Welf 2019 Nov;78(11 Suppl 2):6-10. PMID: 31773104Free PMC Article
Lipofibromatous hamartoma of the median nerve.
Agarwal S, Haase SC
J Hand Surg Am 2013 Feb;38(2):392-7; quiz 397. Epub 2012 Dec 23 doi: 10.1016/j.jhsa.2012.10.042. PMID: 23266006
Carpal tunnel syndrome.
McCartan B, Ashby E, Taylor EJ, Haddad FS
Br J Hosp Med (Lond) 2012 Apr;73(4):199-202. doi: 10.12968/hmed.2012.73.4.199. PMID: 22585195

Therapy

Comparative Efficacy of Routine Physical Therapy with and without Neuromobilization in the Treatment of Patients with Mild to Moderate Carpal Tunnel Syndrome.
Ijaz MJ, Karimi H, Ahmad A, Gillani SA, Anwar N, Chaudhary MA
Biomed Res Int 2022;2022:2155765. Epub 2022 Jun 22 doi: 10.1155/2022/2155765. PMID: 35782066Free PMC Article
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review.
Jiménez Del Barrio S, Bueno Gracia E, Hidalgo García C, Estébanez de Miguel E, Tricás Moreno JM, Rodríguez Marco S, Ceballos Laita L
Neurologia (Engl Ed) 2018 Nov-Dec;33(9):590-601. Epub 2016 Jul 22 doi: 10.1016/j.nrl.2016.05.018. PMID: 27461181
Efficacy of Manual Therapy Including Neurodynamic Techniques for the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial.
Wolny T, Saulicz E, Linek P, Shacklock M, Myśliwiec A
J Manipulative Physiol Ther 2017 May;40(4):263-272. Epub 2017 Apr 8 doi: 10.1016/j.jmpt.2017.02.004. PMID: 28395984
Carpal Tunnel Syndrome: Diagnosis and Management.
Wipperman J, Goerl K
Am Fam Physician 2016 Dec 15;94(12):993-999. PMID: 28075090

Prognosis

Carpal tunnel sonography.
Gervasio A, Stelitano C, Bollani P, Giardini A, Vanzetti E, Ferrari M
J Ultrasound 2020 Sep;23(3):337-347. Epub 2020 Apr 22 doi: 10.1007/s40477-020-00460-z. PMID: 32323256Free PMC Article
Anatomy of the median nerve and its clinical applications.
Soubeyrand M, Melhem R, Protais M, Artuso M, Crézé M
Hand Surg Rehabil 2020 Feb;39(1):2-18. Epub 2019 Dec 6 doi: 10.1016/j.hansur.2019.10.197. PMID: 31816428
Efficacy of Manual Therapy Including Neurodynamic Techniques for the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial.
Wolny T, Saulicz E, Linek P, Shacklock M, Myśliwiec A
J Manipulative Physiol Ther 2017 May;40(4):263-272. Epub 2017 Apr 8 doi: 10.1016/j.jmpt.2017.02.004. PMID: 28395984
Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.
Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V
Brain 2017 Apr 1;140(4):914-927. doi: 10.1093/brain/awx015. PMID: 28334999Free PMC Article
Lipofibromatous hamartoma of the median nerve.
Agarwal S, Haase SC
J Hand Surg Am 2013 Feb;38(2):392-7; quiz 397. Epub 2012 Dec 23 doi: 10.1016/j.jhsa.2012.10.042. PMID: 23266006

Clinical prediction guides

Carpal tunnel syndrome: state-of-the-art review.
Osiak K, Elnazir P, Walocha JA, Pasternak A
Folia Morphol (Warsz) 2022;81(4):851-862. Epub 2021 Nov 16 doi: 10.5603/FM.a2021.0121. PMID: 34783004
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture.
Maeda Y, Kim H, Kettner N, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Ong-Sutherland R, Mezzacappa P, Libby A, Mawla I, Morse LR, Kaptchuk TJ, Audette J, Napadow V
Brain 2017 Apr 1;140(4):914-927. doi: 10.1093/brain/awx015. PMID: 28334999Free PMC Article
Carpal tunnel syndrome.
Patijn J, Vallejo R, Janssen M, Huygen F, Lataster A, van Kleef M, Mekhail N
Pain Pract 2011 May-Jun;11(3):297-301. doi: 10.1111/j.1533-2500.2011.00457.x. PMID: 21435163
A neurophysiological grading scale for carpal tunnel syndrome.
Bland JD
Muscle Nerve 2000 Aug;23(8):1280-3. doi: 10.1002/1097-4598(200008)23:8<1280::aid-mus20>3.0.co;2-y. PMID: 10918269

Recent systematic reviews

Splinting for carpal tunnel syndrome.
Karjalainen TV, Lusa V, Page MJ, O'Connor D, Massy-Westropp N, Peters SE
Cochrane Database Syst Rev 2023 Feb 27;2(2):CD010003. doi: 10.1002/14651858.CD010003.pub2. PMID: 36848651Free PMC Article
The effectiveness of manual therapy on pain, physical function, and nerve conduction studies in carpal tunnel syndrome patients: a systematic review and meta-analysis.
Jiménez-Del-Barrio S, Cadellans-Arróniz A, Ceballos-Laita L, Estébanez-de-Miguel E, López-de-Celis C, Bueno-Gracia E, Pérez-Bellmunt A
Int Orthop 2022 Feb;46(2):301-312. Epub 2021 Dec 3 doi: 10.1007/s00264-021-05272-2. PMID: 34862562Free PMC Article
Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review.
Jiménez Del Barrio S, Bueno Gracia E, Hidalgo García C, Estébanez de Miguel E, Tricás Moreno JM, Rodríguez Marco S, Ceballos Laita L
Neurologia (Engl Ed) 2018 Nov-Dec;33(9):590-601. Epub 2016 Jul 22 doi: 10.1016/j.nrl.2016.05.018. PMID: 27461181
Effectiveness of Nerve Gliding Exercises on Carpal Tunnel Syndrome: A Systematic Review.
Ballestero-Pérez R, Plaza-Manzano G, Urraca-Gesto A, Romo-Romo F, Atín-Arratibel MLÁ, Pecos-Martín D, Gallego-Izquierdo T, Romero-Franco N
J Manipulative Physiol Ther 2017 Jan;40(1):50-59. Epub 2016 Nov 11 doi: 10.1016/j.jmpt.2016.10.004. PMID: 27842937
Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain.
van der Windt DA, Simons E, Riphagen II, Ammendolia C, Verhagen AP, Laslett M, Devillé W, Deyo RA, Bouter LM, de Vet HC, Aertgeerts B
Cochrane Database Syst Rev 2010 Feb 17;(2):CD007431. doi: 10.1002/14651858.CD007431.pub2. PMID: 20166095

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