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OBESITY (BMIQ9), SUSCEPTIBILITY TO(BMIQ9)

MedGen UID:
393673
•Concept ID:
C2677162
•
Finding
Synonyms: BMIQ9; BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 9; Obesity, Susceptibility to, MC3R-Related
 
Gene (location): MC3R (20q13.2)
 
OMIM®: 602025

Recent clinical studies

Etiology

The hematologic consequences of obesity.
Purdy JC, Shatzel JJ
Eur J Haematol 2021 Mar;106(3):306-319. Epub 2020 Dec 13 doi: 10.1111/ejh.13560. PMID: 33270290Free PMC Article
Obesity and asthma.
Miethe S, Karsonova A, Karaulov A, Renz H
J Allergy Clin Immunol 2020 Oct;146(4):685-693. doi: 10.1016/j.jaci.2020.08.011. PMID: 33032723
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Obesity and female infertility: potential mediators of obesity's impact.
Broughton DE, Moley KH
Fertil Steril 2017 Apr;107(4):840-847. Epub 2017 Mar 11 doi: 10.1016/j.fertnstert.2017.01.017. PMID: 28292619
Physical activity and obesity in children.
Hills AP, Andersen LB, Byrne NM
Br J Sports Med 2011 Sep;45(11):866-70. doi: 10.1136/bjsports-2011-090199. PMID: 21836171

Diagnosis

Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity.
Tilg H, Adolph TE, Dudek M, Knolle P
Nat Metab 2021 Dec;3(12):1596-1607. Epub 2021 Dec 20 doi: 10.1038/s42255-021-00501-9. PMID: 34931080
Lipedema: A Call to Action!
Buso G, Depairon M, Tomson D, Raffoul W, Vettor R, Mazzolai L
Obesity (Silver Spring) 2019 Oct;27(10):1567-1576. doi: 10.1002/oby.22597. PMID: 31544340Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716

Therapy

Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome.
Green M, Arora K, Prakash S
Int J Mol Sci 2020 Apr 21;21(8) doi: 10.3390/ijms21082890. PMID: 32326175Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Healthy Weight and Obesity Prevention: JACC Health Promotion Series.
Lavie CJ, Laddu D, Arena R, Ortega FB, Alpert MA, Kushner RF
J Am Coll Cardiol 2018 Sep 25;72(13):1506-1531. doi: 10.1016/j.jacc.2018.08.1037. PMID: 30236314
Obesity and female infertility: potential mediators of obesity's impact.
Broughton DE, Moley KH
Fertil Steril 2017 Apr;107(4):840-847. Epub 2017 Mar 11 doi: 10.1016/j.fertnstert.2017.01.017. PMID: 28292619

Prognosis

Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
Epigenetics in Human Obesity and Type 2 Diabetes.
Ling C, Rönn T
Cell Metab 2019 May 7;29(5):1028-1044. Epub 2019 Apr 11 doi: 10.1016/j.cmet.2019.03.009. PMID: 30982733Free PMC Article
Determinants and Consequences of Obesity.
Hruby A, Manson JE, Qi L, Malik VS, Rimm EB, Sun Q, Willett WC, Hu FB
Am J Public Health 2016 Sep;106(9):1656-62. Epub 2016 Jul 26 doi: 10.2105/AJPH.2016.303326. PMID: 27459460Free PMC Article
Pathophysiology of human visceral obesity: an update.
Tchernof A, Després JP
Physiol Rev 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. PMID: 23303913

Clinical prediction guides

Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Genetics of Obesity: What We Have Learned Over Decades of Research.
Bouchard C
Obesity (Silver Spring) 2021 May;29(5):802-820. doi: 10.1002/oby.23116. PMID: 33899337
The hematologic consequences of obesity.
Purdy JC, Shatzel JJ
Eur J Haematol 2021 Mar;106(3):306-319. Epub 2020 Dec 13 doi: 10.1111/ejh.13560. PMID: 33270290Free PMC Article
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716

Recent systematic reviews

Mendelian Randomization Studies in Atopic Dermatitis: A Systematic Review.
Elhage KG, Kranyak A, Jin JQ, Haran K, Spencer RK, Smith PL, Davis MS, Hakimi M, Bhutani T, Liao W
J Invest Dermatol 2024 May;144(5):1022-1037. Epub 2023 Nov 17 doi: 10.1016/j.jid.2023.10.016. PMID: 37977498
Infections and Autoimmunity-The Immune System and Vitamin D: A Systematic Review.
Wimalawansa SJ
Nutrients 2023 Sep 2;15(17) doi: 10.3390/nu15173842. PMID: 37686873Free PMC Article
Systematic review and meta-analysis of breastfeeding and later overweight or obesity expands on previous study for World Health Organization.
Horta BL, Rollins N, Dias MS, Garcez V, Pérez-Escamilla R
Acta Paediatr 2023 Jan;112(1):34-41. Epub 2022 Jul 1 doi: 10.1111/apa.16460. PMID: 35727183
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA
Front Immunol 2019;10:2349. Epub 2019 Oct 1 doi: 10.3389/fimmu.2019.02349. PMID: 31681268Free PMC Article

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    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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