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Lumbar disk herniation, susceptibility to

MedGen UID:
393597
•Concept ID:
C2676840
•
Finding
Synonym: Lumbar disc herniation, susceptibility to
 
Monarch Initiative: MONDO:0100202
OMIM®: 120280; 188061; 603932

Professional guidelines

PubMed

Type IX collagen neo-deposition in degenerative discs of surgical patients whether genotyped plus or minus for COL9 risk alleles.
Zhu Y, Wu JJ, Weis MA, Mirza SK, Eyre DR
Spine (Phila Pa 1976) 2011 Nov 15;36(24):2031-8. doi: 10.1097/BRS.0b013e3181ffdd61. PMID: 21311409Free PMC Article
Association of interleukin-1 receptor antagonist gene polymorphism with response to conservative treatment of lumbar herniated nucleus pulposus.
Kim DH, Lee SH, Kim KT, Yu SD
Spine (Phila Pa 1976) 2010 Jul 15;35(16):1527-31. doi: 10.1097/BRS.0b013e3181e4efb6. PMID: 20581747
Management of deep wound infection after posterior lumbar interbody fusion with cages.
Mirovsky Y, Floman Y, Smorgick Y, Ashkenazi E, Anekstein Y, Millgram MA, Giladi M
J Spinal Disord Tech 2007 Apr;20(2):127-31. doi: 10.1097/01.bsd.0000211266.66615.e5. PMID: 17414981

Recent clinical studies

Etiology

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations.
Salo V, Määttä J, Sliz E; FinnGen, Reimann E, Mägi R; Estonian Biobank Research Team, Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Karppinen J, Kettunen J
Nat Commun 2024 Nov 7;15(1):9424. doi: 10.1038/s41467-024-53467-z. PMID: 39511132Free PMC Article
The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.
Han P, Jiang F, Zhang L
Eur Spine J 2023 Apr;32(4):1106-1114. Epub 2023 Feb 21 doi: 10.1007/s00586-023-07586-8. PMID: 36810712
Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study.
Guan Y, Wang S, Wang J, Meng D, Wu H, Wei Q, Jiang H
J Orthop Surg Res 2020 Feb 18;15(1):54. doi: 10.1186/s13018-020-01588-8. PMID: 32070384Free PMC Article
Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients.
Theodore N, Ahmed AK, Fulton T, Mousses S, Yoo C, Goodwin CR, Danielson J, Sciubba DM, Giers MB, Kalani MYS
Spine (Phila Pa 1976) 2019 Jun 1;44(11):E640-E649. doi: 10.1097/BRS.0000000000002949. PMID: 30475332
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
Wu H, Wang S, Chen W, Zhan X, Xiao Z, Jiang H, Wei Q
J Orthop Surg Res 2018 Mar 5;13(1):47. doi: 10.1186/s13018-018-0750-0. PMID: 29506578Free PMC Article

Diagnosis

Assessment of MIR3142HG genetic polymorphisms and the susceptibility of lumbar disc herniation in the Chinese population.
Dong Q, Ren G, Hao D
Sci Rep 2024 Nov 28;14(1):29542. doi: 10.1038/s41598-024-80758-8. PMID: 39604548Free PMC Article
MAS-Net:Multi-modal Assistant Segmentation Network For Lumbar Intervertebral Disc.
Qinhong D, Yue H, Wendong B, Yukun D, Huan Y, Yongming X
Phys Med Biol 2023 Aug 29;68(17) doi: 10.1088/1361-6560/acef9f. PMID: 37567228
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
Degenerative disc disease in childhood and adolescence.
Young JP, Young PH
Mo Med 2005 Jan-Feb;102(1):70-2. PMID: 15754623
Magnetic resonance imaging of adolescent disc herniation.
Gibson MJ, Szypryt EP, Buckley JH, Worthington BS, Mulholland RC
J Bone Joint Surg Br 1987 Nov;69(5):699-703. doi: 10.1302/0301-620X.69B5.3680327. PMID: 3680327

Therapy

Changes in Intervertebral Disc Properties after Intradiscal Injection of Condoliase for Painful Lumbar Disc Herniation.
Ohtonari T, Sakai K, Furukawa Y, Takeda Y
Neurol Med Chir (Tokyo) 2024 Jun 15;64(6):222-229. Epub 2024 May 8 doi: 10.2176/jns-nmc.2023-0302. PMID: 38719578Free PMC Article
Degenerate-disc infection study with contaminant control (DISC): a multicenter prospective case-control trial.
Rao PJ, Maharaj M, Chau C, Taylor P, Phan K, Choy WJ, Scherman D, Mews P, Scholsem M, Coughlan M, Mobbs R
Spine J 2020 Oct;20(10):1544-1553. Epub 2020 Apr 25 doi: 10.1016/j.spinee.2020.03.013. PMID: 32339766
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.
Bjornsdottir G, Benonisdottir S, Sveinbjornsson G, Styrkarsdottir U, Thorleifsson G, Walters GB, Bjornsson A, Olafsson IH, Ulfarsson E, Vikingsson A, Hansdottir R, Karlsson KO, Rafnar T, Jonsdottir I, Frigge ML, Kong A, Oddsson A, Masson G, Magnusson OT, Gudbjartsson T, Stefansson H, Sulem P, Gudbjartsson D, Thorsteinsdottir U, Thorgeirsson TE, Stefansson K
Nat Commun 2017 Feb 22;8:14265. doi: 10.1038/ncomms14265. PMID: 28223688Free PMC Article
Propionibacterium acnes osteomyelitis: case report and review of the literature.
Noble RC, Overman SB
J Clin Microbiol 1987 Feb;25(2):251-4. doi: 10.1128/jcm.25.2.251-254.1987. PMID: 3818921Free PMC Article
Early, interim and long term observations on chemonucleolysis in 876 patients with special comments on the lateral approach.
Day PL
Clin Orthop Relat Res 1974 Mar-Apr;(99):63-9. PMID: 4825720

Prognosis

Assessment of MIR3142HG genetic polymorphisms and the susceptibility of lumbar disc herniation in the Chinese population.
Dong Q, Ren G, Hao D
Sci Rep 2024 Nov 28;14(1):29542. doi: 10.1038/s41598-024-80758-8. PMID: 39604548Free PMC Article
The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.
Han P, Jiang F, Zhang L
Eur Spine J 2023 Apr;32(4):1106-1114. Epub 2023 Feb 21 doi: 10.1007/s00586-023-07586-8. PMID: 36810712
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
The interaction between aggrecan gene VNTR polymorphism and obesity in predicting incident symptomatic lumbar disc herniation.
Cong L, Zhu Y, Pang H, Guanjun TU
Connect Tissue Res 2014 Oct-Dec;55(5-6):384-90. Epub 2014 Sep 22 doi: 10.3109/03008207.2014.959117. PMID: 25188217
The genetics of intervertebral disc degeneration. Associated genes.
Kalichman L, Hunter DJ
Joint Bone Spine 2008 Jul;75(4):388-96. Epub 2008 May 15 doi: 10.1016/j.jbspin.2007.11.002. PMID: 18485784

Clinical prediction guides

Assessment of MIR3142HG genetic polymorphisms and the susceptibility of lumbar disc herniation in the Chinese population.
Dong Q, Ren G, Hao D
Sci Rep 2024 Nov 28;14(1):29542. doi: 10.1038/s41598-024-80758-8. PMID: 39604548Free PMC Article
Why Are Some Intervertebral Discs More Prone to Degeneration?: Insights Into Isolated Thoracic "Dysgeneration".
Cheung STY, Cheung PWH, Cheung JPY
Spine (Phila Pa 1976) 2023 Jun 15;48(12):E177-E187. Epub 2023 Mar 22 doi: 10.1097/BRS.0000000000004632. PMID: 37262423Free PMC Article
The role of ADAMTS6 and ADAMTS17 polymorphisms in susceptibility to lumbar disc herniation in Chinese Han population.
Han P, Jiang F, Zhang L
Eur Spine J 2023 Apr;32(4):1106-1114. Epub 2023 Feb 21 doi: 10.1007/s00586-023-07586-8. PMID: 36810712
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population.
Hu X, Hao D, Yin J, Gong F, Wang X, Wang R, Liu B
Cell Cycle 2022 Oct;21(19):2109-2120. Epub 2022 Jun 15 doi: 10.1080/15384101.2022.2087281. PMID: 35704669Free PMC Article
Genetic Predisposition to Symptomatic Lumbar Disk Herniation in Pediatric and Young Adult Patients.
Theodore N, Ahmed AK, Fulton T, Mousses S, Yoo C, Goodwin CR, Danielson J, Sciubba DM, Giers MB, Kalani MYS
Spine (Phila Pa 1976) 2019 Jun 1;44(11):E640-E649. doi: 10.1097/BRS.0000000000002949. PMID: 30475332

Recent systematic reviews

Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study.
Guan Y, Wang S, Wang J, Meng D, Wu H, Wei Q, Jiang H
J Orthop Surg Res 2020 Feb 18;15(1):54. doi: 10.1186/s13018-020-01588-8. PMID: 32070384Free PMC Article
Collagen IX gene polymorphisms and lumbar disc degeneration: a systematic review and meta-analysis.
Wu H, Wang S, Chen W, Zhan X, Xiao Z, Jiang H, Wei Q
J Orthop Surg Res 2018 Mar 5;13(1):47. doi: 10.1186/s13018-018-0750-0. PMID: 29506578Free PMC Article
Genetic association studies in lumbar disc degeneration: a systematic review.
Eskola PJ, Lemmelä S, Kjaer P, Solovieva S, Männikkö M, Tommerup N, Lind-Thomsen A, Husgafvel-Pursiainen K, Cheung KM, Chan D, Samartzis D, Karppinen J
PLoS One 2012;7(11):e49995. Epub 2012 Nov 21 doi: 10.1371/journal.pone.0049995. PMID: 23185509Free PMC Article

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