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Microvascular complications of diabetes, susceptibility to, 3(MVCD3)

MedGen UID:
390806
•Concept ID:
C2675470
•
Finding
Synonym: Microvascular complications of diabetes 3
 
Gene (location): ACE (17q23.3)
 
Monarch Initiative: MONDO:0012963
OMIM®: 612624

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the ACE gene. [from MONDO]

Professional guidelines

PubMed

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies.
Bloom RD, Crutchlow MF
Clin J Am Soc Nephrol 2008 Mar;3 Suppl 2(Suppl 2):S38-48. doi: 10.2215/CJN.02650707. PMID: 18309002Free PMC Article

Recent clinical studies

Etiology

Genetic basis of early onset and progression of type 2 diabetes in South Asians.
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J, Spreckley M; Genes & Health Research Team, Langenberg C, van Heel DA, Mathur R, Siddiqui MK, Finer S
Nat Med 2025 Jan;31(1):323-331. Epub 2024 Nov 26 doi: 10.1038/s41591-024-03317-8. PMID: 39592779Free PMC Article
Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study.
Li Y, Miao Y, Feng Q, Zhu W, Chen Y, Kang Q, Wang Z, Lu F, Zhang Q
Front Endocrinol (Lausanne) 2024;15:1401531. Epub 2024 Aug 30 doi: 10.3389/fendo.2024.1401531. PMID: 39280009Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Emerging molecular mechanisms of vascular dementia.
Romay MC, Toro C, Iruela-Arispe ML
Curr Opin Hematol 2019 May;26(3):199-206. doi: 10.1097/MOH.0000000000000502. PMID: 30883434Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294

Diagnosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Genetic basis of early onset and progression of type 2 diabetes in South Asians.
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J, Spreckley M; Genes & Health Research Team, Langenberg C, van Heel DA, Mathur R, Siddiqui MK, Finer S
Nat Med 2025 Jan;31(1):323-331. Epub 2024 Nov 26 doi: 10.1038/s41591-024-03317-8. PMID: 39592779Free PMC Article
Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Inflammatory and angiogenic biomarkers in diabetic retinopathy.
Kaštelan S, Orešković I, Bišćan F, Kaštelan H, Gverović Antunica A
Biochem Med (Zagreb) 2020 Oct 15;30(3):030502. Epub 2020 Aug 5 doi: 10.11613/BM.2020.030502. PMID: 32774120Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294

Therapy

Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study.
Li Y, Miao Y, Feng Q, Zhu W, Chen Y, Kang Q, Wang Z, Lu F, Zhang Q
Front Endocrinol (Lausanne) 2024;15:1401531. Epub 2024 Aug 30 doi: 10.3389/fendo.2024.1401531. PMID: 39280009Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article
The role of inflammatory cytokines in diabetic nephropathy.
Navarro-González JF, Mora-Fernández C
J Am Soc Nephrol 2008 Mar;19(3):433-42. Epub 2008 Feb 6 doi: 10.1681/ASN.2007091048. PMID: 18256353

Prognosis

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes.
Słomiński B, Skrzypkowska M, Ryba-Stanisławowska M, Myśliwiec M, Trzonkowski P
J Mol Med (Berl) 2021 May;99(5):675-683. Epub 2021 Jan 25 doi: 10.1007/s00109-020-02035-1. PMID: 33495869Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294

Clinical prediction guides

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.
Hansen AL, Andersen MK, Engelhard LM, Brøns C, Hansen T, Nielsen JS, Vestergaard P, Højlund K, Jessen N, Olsen MH, Thomsen RW, Vaag A
Diabetes Obes Metab 2025 Apr;27(4):2002-2011. Epub 2025 Jan 8 doi: 10.1111/dom.16193. PMID: 39780311
Genetic basis of early onset and progression of type 2 diabetes in South Asians.
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J, Spreckley M; Genes & Health Research Team, Langenberg C, van Heel DA, Mathur R, Siddiqui MK, Finer S
Nat Med 2025 Jan;31(1):323-331. Epub 2024 Nov 26 doi: 10.1038/s41591-024-03317-8. PMID: 39592779Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Microvascular complications and diabetic retinopathy: recent advances and future implications.
Barot M, Gokulgandhi MR, Patel S, Mitra AK
Future Med Chem 2013 Mar;5(3):301-14. doi: 10.4155/fmc.12.206. PMID: 23464520Free PMC Article

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

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      Clinical tests in GTR
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