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Leydig cell adenoma, somatic, with male-limited precocious puberty

MedGen UID:
393190
•Concept ID:
C2674612
•
Neoplastic Process
Synonym: Leydig Cell Adenoma, Somatic, with Male-Limited Precocious Puberty
 
OMIM®: 152790; 176410

Recent clinical studies

Etiology

Gonadotrophin receptors.
Clayton RN
Baillieres Clin Endocrinol Metab 1996 Jan;10(1):1-8. doi: 10.1016/s0950-351x(96)80250-3. PMID: 8734448

Diagnosis

Inherited disorders of GnRH and gonadotropin receptors.
de Roux N, Milgrom E
Mol Cell Endocrinol 2001 Jun 20;179(1-2):83-7. doi: 10.1016/s0303-7207(01)00471-3. PMID: 11420132

Prognosis

Gonadotrophin receptors.
Clayton RN
Baillieres Clin Endocrinol Metab 1996 Jan;10(1):1-8. doi: 10.1016/s0950-351x(96)80250-3. PMID: 8734448
Somatic and germinal cells' interrelationship in the course of seminiferous tubule maturation in man.
Kula K, Romer TE, Wlodarczyk WP
Arch Androl 1980 Feb;4(1):9-16. doi: 10.3109/01485018008988274. PMID: 7356377

Clinical prediction guides

Testotoxicosis without Testicular Mass: Revealed by Peripheral Precocious Puberty and Confirmed by Somatic LHCGR Gene Mutation.
Daussac A, Barat P, Servant N, Yacoub M, Missonier S, Lavran F, Gaspari L, Sultan C, Paris F
Endocr Res 2020 Feb;45(1):32-40. Epub 2019 Aug 8 doi: 10.1080/07435800.2019.1645163. PMID: 31394950
Gonadotrophin receptors.
Clayton RN
Baillieres Clin Endocrinol Metab 1996 Jan;10(1):1-8. doi: 10.1016/s0950-351x(96)80250-3. PMID: 8734448
Somatic and germinal cells' interrelationship in the course of seminiferous tubule maturation in man.
Kula K, Romer TE, Wlodarczyk WP
Arch Androl 1980 Feb;4(1):9-16. doi: 10.3109/01485018008988274. PMID: 7356377

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