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Intractable seizure

MedGen UID:
388894
•Concept ID:
C2674422
•
Disease or Syndrome
Synonym: Intractable seizures

Professional guidelines

PubMed

Changing Landscape of Dravet Syndrome Management: An Overview.
Samanta D
Neuropediatrics 2020 Apr;51(2):135-145. Epub 2020 Feb 20 doi: 10.1055/s-0040-1701694. PMID: 32079034
MicroRNAs in epilepsy: pathophysiology and clinical utility.
Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F
Lancet Neurol 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. PMID: 27839653
Update on the management of Lennox-Gastaut syndrome.
VanStraten AF, Ng YT
Pediatr Neurol 2012 Sep;47(3):153-61. doi: 10.1016/j.pediatrneurol.2012.05.001. PMID: 22883278

Recent clinical studies

Etiology

Changing Landscape of Dravet Syndrome Management: An Overview.
Samanta D
Neuropediatrics 2020 Apr;51(2):135-145. Epub 2020 Feb 20 doi: 10.1055/s-0040-1701694. PMID: 32079034
MicroRNAs in epilepsy: pathophysiology and clinical utility.
Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F
Lancet Neurol 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. PMID: 27839653
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Miliauskas S, Liesiene V, Zemaitis M, Sakalauskas R
Medicina (Kaunas) 2010;46(2):120-4. PMID: 20440085
Magnetocephalography: a noninvasive alternative to the Wada procedure.
Papanicolaou AC, Simos PG, Castillo EM, Breier JI, Sarkari S, Pataraia E, Billingsley RL, Buchanan S, Wheless J, Maggio V, Maggio WW
J Neurosurg 2004 May;100(5):867-76. doi: 10.3171/jns.2004.100.5.0867. PMID: 15137606
Ictal and interictal SPECT in a newborn infant with intractable seizure.
Koç E, Serdaroğlu A, Kapucu O, Atalay Y, Gücüyener K, Atasever T
Acta Paediatr 1997 Dec;86(12):1379-81. doi: 10.1111/j.1651-2227.1997.tb14918.x. PMID: 9475321

Diagnosis

Intractable Seizure With Hypoglycemia: A Mysterious Retroperitoneal Fibrosarcoma.
Midi I, Okay BB, Cetin SZ, Ekinci G
Prim Care Companion CNS Disord 2022 Jul 28;24(4) doi: 10.4088/PCC.21cr03117. PMID: 35926855
Creatine deficiency syndromes.
Schulze A
Handb Clin Neurol 2013;113:1837-43. doi: 10.1016/B978-0-444-59565-2.00053-8. PMID: 23622406
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Miliauskas S, Liesiene V, Zemaitis M, Sakalauskas R
Medicina (Kaunas) 2010;46(2):120-4. PMID: 20440085
Magnetocephalography: a noninvasive alternative to the Wada procedure.
Papanicolaou AC, Simos PG, Castillo EM, Breier JI, Sarkari S, Pataraia E, Billingsley RL, Buchanan S, Wheless J, Maggio V, Maggio WW
J Neurosurg 2004 May;100(5):867-76. doi: 10.3171/jns.2004.100.5.0867. PMID: 15137606
Use of routine and video electroencephalography.
Cascino GD
Neurol Clin 2001 May;19(2):271-87. doi: 10.1016/s0733-8619(05)70019-0. PMID: 11358745

Therapy

Changing Landscape of Dravet Syndrome Management: An Overview.
Samanta D
Neuropediatrics 2020 Apr;51(2):135-145. Epub 2020 Feb 20 doi: 10.1055/s-0040-1701694. PMID: 32079034
Hashimoto's encephalopathy: a rare pediatric brain disease.
Farrell RM, Foster MB, Omoruyi AO, Kingery SE, Wintergerst KA
J Pediatr Endocrinol Metab 2015 May;28(5-6):721-4. doi: 10.1515/jpem-2014-0205. PMID: 25581742
Update on the management of Lennox-Gastaut syndrome.
VanStraten AF, Ng YT
Pediatr Neurol 2012 Sep;47(3):153-61. doi: 10.1016/j.pediatrneurol.2012.05.001. PMID: 22883278
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Miliauskas S, Liesiene V, Zemaitis M, Sakalauskas R
Medicina (Kaunas) 2010;46(2):120-4. PMID: 20440085
Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study.
Adams DJ, Luders H, Pippenger C
Neurology 1978 Feb;28(2):152-7. doi: 10.1212/wnl.28.2.152. PMID: 414151

Prognosis

Optimism and pessimism as predictors of seizure group among patients with intractable seizure disorders.
Griffith NM, Schefft BK
Epilepsy Behav 2023 Mar;140:109094. Epub 2023 Feb 1 doi: 10.1016/j.yebeh.2023.109094. PMID: 36736238
Update on the management of Lennox-Gastaut syndrome.
VanStraten AF, Ng YT
Pediatr Neurol 2012 Sep;47(3):153-61. doi: 10.1016/j.pediatrneurol.2012.05.001. PMID: 22883278
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Miliauskas S, Liesiene V, Zemaitis M, Sakalauskas R
Medicina (Kaunas) 2010;46(2):120-4. PMID: 20440085
Magnetocephalography: a noninvasive alternative to the Wada procedure.
Papanicolaou AC, Simos PG, Castillo EM, Breier JI, Sarkari S, Pataraia E, Billingsley RL, Buchanan S, Wheless J, Maggio V, Maggio WW
J Neurosurg 2004 May;100(5):867-76. doi: 10.3171/jns.2004.100.5.0867. PMID: 15137606
Hemispheric epilepsy.
Blume WT
Brain 1998 Oct;121 ( Pt 10):1937-49. doi: 10.1093/brain/121.10.1937. PMID: 9798748

Clinical prediction guides

Optimism and pessimism as predictors of seizure group among patients with intractable seizure disorders.
Griffith NM, Schefft BK
Epilepsy Behav 2023 Mar;140:109094. Epub 2023 Feb 1 doi: 10.1016/j.yebeh.2023.109094. PMID: 36736238
The Role of Radionuclide Imaging in Epilepsy, Part 1: Sporadic Temporal and Extratemporal Lobe Epilepsy.
Kumar A, Chugani HT
J Nucl Med Technol 2017 Mar;45(1):14-21. doi: 10.2967/jnumed.112.114397. PMID: 28258205
Use of routine and video electroencephalography.
Cascino GD
Neurol Clin 2001 May;19(2):271-87. doi: 10.1016/s0733-8619(05)70019-0. PMID: 11358745
Current trends in electroencephalography.
Blume WT
Curr Opin Neurol 2001 Apr;14(2):193-7. doi: 10.1097/00019052-200104000-00010. PMID: 11262735
Gap junction gene expression in human seizure disorder.
Naus CC, Bechberger JF, Paul DL
Exp Neurol 1991 Feb;111(2):198-203. doi: 10.1016/0014-4886(91)90007-y. PMID: 1846600

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