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Kala-azar susceptibility 2(KAZA2)

MedGen UID:
409879
•Concept ID:
C1969649
•
Finding
Synonyms: KALA-AZAR, SUSCEPTIBILITY TO, 2; KAZA2; LEISHMANIASIS, VISCERAL, SUSCEPTIBILITY TO, 2
 
Monarch Initiative: MONDO:0012660
OMIM®: 611381

Professional guidelines

PubMed

Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia.
Palić S, Chu WY, Sundar S, Mondal D, Das P, Pandey K, Raja S, Rijal S, Roseboom IC, Hamadeh A, Malik PRV, Beijnen JH, Huitema ADR, Sjögren E, Alves F, Dorlo TPC
J Antimicrob Chemother 2024 Jul 1;79(7):1547-1554. doi: 10.1093/jac/dkae129. PMID: 38727613Free PMC Article
In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.
Kumar D, Kulshrestha A, Singh R, Salotra P
Antimicrob Agents Chemother 2009 Feb;53(2):835-8. Epub 2008 Nov 17 doi: 10.1128/AAC.01233-08. PMID: 19015344Free PMC Article
Leishmaniasis: recognition and management with a focus on the immunocompromised patient.
Choi CM, Lerner EA
Am J Clin Dermatol 2002;3(2):91-105. doi: 10.2165/00128071-200203020-00003. PMID: 11893221

Recent clinical studies

Etiology

Human genetics of leishmania infections.
Blackwell JM, Fakiola M, Castellucci LC
Hum Genet 2020 Jun;139(6-7):813-819. Epub 2020 Feb 13 doi: 10.1007/s00439-020-02130-w. PMID: 32055998Free PMC Article
Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.
Braliou GG, Kontou PI, Boleti H, Bagos PG
Parasitol Res 2019 Aug;118(8):2329-2342. Epub 2019 Jun 23 doi: 10.1007/s00436-019-06374-y. PMID: 31230160
Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.
Weirather JL, Duggal P, Nascimento EL, Monteiro GR, Martins DR, Lacerda HG, Fakiola M, Blackwell JM, Jeronimo SM, Wilson ME
Ann Hum Genet 2017 Jan;81(1):41-48. Epub 2017 Jan 4 doi: 10.1111/ahg.12180. PMID: 28054334Free PMC Article
Evaluation of IFN-γ polymorphism in visceral leishmaniasis.
Maghsood AH, Jadideslam G, Fallah M, Bazmani A
J Res Health Sci 2014 Spring;14(2):136-9. PMID: 24728749
CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis.
Hashemi SH, Hajilooi M, Fallah M, Naghili B
Trop Biomed 2010 Aug;27(2):193-9. PMID: 20962715

Diagnosis

Post kala-azar dermal leishmaniasis: A threat to elimination program.
Gedda MR, Singh B, Kumar D, Singh AK, Madhukar P, Upadhyay S, Singh OP, Sundar S
PLoS Negl Trop Dis 2020 Jul;14(7):e0008221. Epub 2020 Jul 2 doi: 10.1371/journal.pntd.0008221. PMID: 32614818Free PMC Article
Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure.
Berg M, Vanaerschot M, Jankevics A, Cuypers B, Maes I, Mukherjee S, Khanal B, Rijal S, Roy S, Opperdoes F, Breitling R, Dujardin JC
Mol Microbiol 2013 Oct;90(2):428-42. Epub 2013 Sep 11 doi: 10.1111/mmi.12374. PMID: 24020363
Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarray.
Singh N, Almeida R, Kothari H, Kumar P, Mandal G, Chatterjee M, Venkatachalam S, Govind MK, Mandal SK, Sundar S
Parasitology 2007 Jun;134(Pt 6):777-87. Epub 2007 Feb 19 doi: 10.1017/S0031182007002284. PMID: 17306059
Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis.
Basu R, Bhaumik S, Basu JM, Naskar K, De T, Roy S
J Immunol 2005 Jun 1;174(11):7160-71. doi: 10.4049/jimmunol.174.11.7160. PMID: 15905560
Prevalence and disease spectrum in a new focus of visceral leishmaniasis in Kenya.
Ho M, Siongok TK, Lyerly WH, Smith DH
Trans R Soc Trop Med Hyg 1982;76(6):741-6. doi: 10.1016/0035-9203(82)90095-5. PMID: 6984547

Therapy

Post kala-azar dermal leishmaniasis: A threat to elimination program.
Gedda MR, Singh B, Kumar D, Singh AK, Madhukar P, Upadhyay S, Singh OP, Sundar S
PLoS Negl Trop Dis 2020 Jul;14(7):e0008221. Epub 2020 Jul 2 doi: 10.1371/journal.pntd.0008221. PMID: 32614818Free PMC Article
Post kala-azar dermal leishmaniasis: an unresolved mystery.
Mukhopadhyay D, Dalton JE, Kaye PM, Chatterjee M
Trends Parasitol 2014 Feb;30(2):65-74. Epub 2014 Jan 2 doi: 10.1016/j.pt.2013.12.004. PMID: 24388776Free PMC Article
In vitro susceptibility of field isolates of Leishmania donovani to Miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity.
Kumar D, Kulshrestha A, Singh R, Salotra P
Antimicrob Agents Chemother 2009 Feb;53(2):835-8. Epub 2008 Nov 17 doi: 10.1128/AAC.01233-08. PMID: 19015344Free PMC Article
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.
Mukherjee A, Padmanabhan PK, Singh S, Roy G, Girard I, Chatterjee M, Ouellette M, Madhubala R
J Antimicrob Chemother 2007 Feb;59(2):204-11. Epub 2007 Jan 9 doi: 10.1093/jac/dkl494. PMID: 17213267
Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis.
Basu R, Bhaumik S, Basu JM, Naskar K, De T, Roy S
J Immunol 2005 Jun 1;174(11):7160-71. doi: 10.4049/jimmunol.174.11.7160. PMID: 15905560

Prognosis

Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.
Braliou GG, Kontou PI, Boleti H, Bagos PG
Parasitol Res 2019 Aug;118(8):2329-2342. Epub 2019 Jun 23 doi: 10.1007/s00436-019-06374-y. PMID: 31230160
A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis.
Carnielli JBT, Crouch K, Forrester S, Silva VC, Carvalho SFG, Damasceno JD, Brown E, Dickens NJ, Costa DL, Costa CHN, Dietze R, Jeffares DC, Mottram JC
EBioMedicine 2018 Oct;36:83-91. Epub 2018 Sep 27 doi: 10.1016/j.ebiom.2018.09.029. PMID: 30268832Free PMC Article
Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines.
Ouakad M, Vanaerschot M, Rijal S, Sundar S, Speybroeck N, Kestens L, Boel L, De Doncker S, Maes I, Decuypere S, Dujardin JC
Parasitology 2011 Sep;138(11):1392-9. Epub 2011 Aug 8 doi: 10.1017/S0031182011001120. PMID: 21819638
Transmission dynamics and underreporting of Kala-azar in the Indian state of Bihar.
Mubayi A, Castillo-Chavez C, Chowell G, Kribs-Zaleta C, Ali Siddiqui N, Kumar N, Das P
J Theor Biol 2010 Jan 7;262(1):177-85. Epub 2009 Sep 19 doi: 10.1016/j.jtbi.2009.09.012. PMID: 19769990
Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study.
Blackwell JM, Black GF, Peacock CS, Miller EN, Sibthorpe D, Gnananandha D, Shaw JJ, Silveira F, Lins-Lainson Z, Ramos F, Collins A, Shaw MA
Philos Trans R Soc Lond B Biol Sci 1997 Sep 29;352(1359):1331-45. doi: 10.1098/rstb.1997.0118. PMID: 9355125Free PMC Article

Clinical prediction guides

Post kala-azar dermal leishmaniasis: A threat to elimination program.
Gedda MR, Singh B, Kumar D, Singh AK, Madhukar P, Upadhyay S, Singh OP, Sundar S
PLoS Negl Trop Dis 2020 Jul;14(7):e0008221. Epub 2020 Jul 2 doi: 10.1371/journal.pntd.0008221. PMID: 32614818Free PMC Article
Human genetics of leishmania infections.
Blackwell JM, Fakiola M, Castellucci LC
Hum Genet 2020 Jun;139(6-7):813-819. Epub 2020 Feb 13 doi: 10.1007/s00439-020-02130-w. PMID: 32055998Free PMC Article
Evaluation of IFN-γ polymorphism in visceral leishmaniasis.
Maghsood AH, Jadideslam G, Fallah M, Bazmani A
J Res Health Sci 2014 Spring;14(2):136-9. PMID: 24728749
CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis.
Hashemi SH, Hajilooi M, Fallah M, Naghili B
Trop Biomed 2010 Aug;27(2):193-9. PMID: 20962715
Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazil.
Jamieson SE, Miller EN, Peacock CS, Fakiola M, Wilson ME, Bales-Holst A, Shaw MA, Silveira F, Shaw JJ, Jeronimo SM, Blackwell JM
Genes Immun 2007 Jan;8(1):84-90. Epub 2006 Nov 23 doi: 10.1038/sj.gene.6364357. PMID: 17122780Free PMC Article

Recent systematic reviews

Serum Levels of Vitamins and Trace Elements in Patients with Visceral Leishmaniasis: a Systematic Review and Meta-analysis.
Chaudhary V, Kumari S, Pal B
Biol Trace Elem Res 2024 Oct;202(10):4345-4356. Epub 2023 Dec 18 doi: 10.1007/s12011-023-04015-1. PMID: 38109004
Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis.
Braliou GG, Kontou PI, Boleti H, Bagos PG
Parasitol Res 2019 Aug;118(8):2329-2342. Epub 2019 Jun 23 doi: 10.1007/s00436-019-06374-y. PMID: 31230160
Factors associated with visceral leishmaniasis in the americas: a systematic review and meta-analysis.
Belo VS, Werneck GL, Barbosa DS, Simões TC, Nascimento BW, da Silva ES, Struchiner CJ
PLoS Negl Trop Dis 2013;7(4):e2182. Epub 2013 Apr 25 doi: 10.1371/journal.pntd.0002182. PMID: 23638203Free PMC Article

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