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Tobacco addiction, susceptibility to

MedGen UID:
348778
Concept ID:
C1861063
Finding
Synonym: CIGARETTE HABITUATION, SUSCEPTIBILITY TO
 
Genes (locations): CHRNA4 (20q13.33); CYP2A6 (19q13.2); GABBR2 (9q22.33); SLC6A3 (5p15.33)
 
Monarch Initiative: MONDO:0100460
OMIM®: 188890

Definition

An inherited susceptibility or predisposition to developing nicotine dependence. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Clair C, Mueller Y, Livingstone-Banks J, Burnand B, Camain JY, Cornuz J, Rège-Walther M, Selby K, Bize R
Cochrane Database Syst Rev 2019 Mar 26;3(3):CD004705. doi: 10.1002/14651858.CD004705.pub5. PMID: 30912847Free PMC Article
O'Neill SC, Lipkus IM, Sanderson SC, Shepperd J, Docherty S, McBride CM
Tob Control 2013 Nov;22(6):406-11. Epub 2012 Jun 28 doi: 10.1136/tobaccocontrol-2011-050306. PMID: 22744911Free PMC Article
Tercyak KP, Peshkin BN, Wine LA, Walker LR
Prev Med 2006 Jan;42(1):60-5. Epub 2005 Nov 2 doi: 10.1016/j.ypmed.2005.09.007. PMID: 16260030

Curated

UK NICE Guideline NG209, Tobacco: preventing uptake, promoting quitting and treating dependence, 2023

Recent clinical studies

Etiology

Hernández-Pérez A, García-Gómez L, Robles-Hernández R, Thirión-Romero I, Osio-Echánove J, Rodríguez-Llamazares S, Baler R, Pérez-Padilla R
Rev Invest Clin 2023;75(3):158-168. doi: 10.24875/RIC.23000117. PMID: 37441760
Zhang Q, Wen C
Front Public Health 2023;11:1146949. Epub 2023 May 15 doi: 10.3389/fpubh.2023.1146949. PMID: 37255760Free PMC Article
Saunders GRB, Wang X, Chen F, Jang SK, Liu M, Wang C, Gao S, Jiang Y, Khunsriraksakul C, Otto JM, Addison C, Akiyama M, Albert CM, Aliev F, Alonso A, Arnett DK, Ashley-Koch AE, Ashrani AA, Barnes KC, Barr RG, Bartz TM, Becker DM, Bielak LF, Benjamin EJ, Bis JC, Bjornsdottir G, Blangero J, Bleecker ER, Boardman JD, Boerwinkle E, Boomsma DI, Boorgula MP, Bowden DW, Brody JA, Cade BE, Chasman DI, Chavan S, Chen YI, Chen Z, Cheng I, Cho MH, Choquet H, Cole JW, Cornelis MC, Cucca F, Curran JE, de Andrade M, Dick DM, Docherty AR, Duggirala R, Eaton CB, Ehringer MA, Esko T, Faul JD, Fernandes Silva L, Fiorillo E, Fornage M, Freedman BI, Gabrielsen ME, Garrett ME, Gharib SA, Gieger C, Gillespie N, Glahn DC, Gordon SD, Gu CC, Gu D, Gudbjartsson DF, Guo X, Haessler J, Hall ME, Haller T, Harris KM, He J, Herd P, Hewitt JK, Hickie I, Hidalgo B, Hokanson JE, Hopfer C, Hottenga J, Hou L, Huang H, Hung YJ, Hunter DJ, Hveem K, Hwang SJ, Hwu CM, Iacono W, Irvin MR, Jee YH, Johnson EO, Joo YY, Jorgenson E, Justice AE, Kamatani Y, Kaplan RC, Kaprio J, Kardia SLR, Keller MC, Kelly TN, Kooperberg C, Korhonen T, Kraft P, Krauter K, Kuusisto J, Laakso M, Lasky-Su J, Lee WJ, Lee JJ, Levy D, Li L, Li K, Li Y, Lin K, Lind PA, Liu C, Lloyd-Jones DM, Lutz SM, Ma J, Mägi R, Manichaikul A, Martin NG, Mathur R, Matoba N, McArdle PF, McGue M, McQueen MB, Medland SE, Metspalu A, Meyers DA, Millwood IY, Mitchell BD, Mohlke KL, Moll M, Montasser ME, Morrison AC, Mulas A, Nielsen JB, North KE, Oelsner EC, Okada Y, Orrù V, Palmer ND, Palviainen T, Pandit A, Park SL, Peters U, Peters A, Peyser PA, Polderman TJC, Rafaels N, Redline S, Reed RM, Reiner AP, Rice JP, Rich SS, Richmond NE, Roan C, Rotter JI, Rueschman MN, Runarsdottir V, Saccone NL, Schwartz DA, Shadyab AH, Shi J, Shringarpure SS, Sicinski K, Skogholt AH, Smith JA, Smith NL, Sotoodehnia N, Stallings MC, Stefansson H, Stefansson K, Stitzel JA, Sun X, Syed M, Tal-Singer R, Taylor AE, Taylor KD, Telen MJ, Thai KK, Tiwari H, Turman C, Tyrfingsson T, Wall TL, Walters RG, Weir DR, Weiss ST, White WB, Whitfield JB, Wiggins KL, Willemsen G, Willer CJ, Winsvold BS, Xu H, Yanek LR, Yin J, Young KL, Young KA, Yu B, Zhao W, Zhou W, Zöllner S, Zuccolo L; 23andMe Research Team; Biobank Japan Project, Batini C, Bergen AW, Bierut LJ, David SP, Gagliano Taliun SA, Hancock DB, Jiang B, Munafò MR, Thorgeirsson TE, Liu DJ, Vrieze S
Nature 2022 Dec;612(7941):720-724. Epub 2022 Dec 7 doi: 10.1038/s41586-022-05477-4. PMID: 36477530Free PMC Article
Ford PJ, Rich AM
Addiction 2021 Dec;116(12):3531-3540. Epub 2021 Apr 25 doi: 10.1111/add.15513. PMID: 33822437
Bernat D, Gasquet N, Wilson KO, Porter L, Choi K
Am J Prev Med 2018 Sep;55(3):361-367. Epub 2018 Jul 19 doi: 10.1016/j.amepre.2018.04.043. PMID: 30031636Free PMC Article

Diagnosis

Vigorita MW, Smith A, Farrelly M, Taylor N, Spinks JG
Addict Behav 2022 Jul;130:107286. Epub 2022 Feb 18 doi: 10.1016/j.addbeh.2022.107286. PMID: 35231844
Icick R, Forget B, Cloëz-Tayarani I, Pons S, Maskos U, Besson M
Neuropharmacology 2020 Oct 15;177:108234. Epub 2020 Jul 29 doi: 10.1016/j.neuropharm.2020.108234. PMID: 32738310
Okoli CT, Rayens MK, Wiggins AT, Ickes MJ, Butler KM, Hahn EJ
J Am Coll Health 2016;64(2):96-103. doi: 10.1080/07448481.2015.1074240. PMID: 26503903Free PMC Article
Benowitz NL
Clin Pharmacol Ther 2008 Apr;83(4):531-41. Epub 2008 Feb 27 doi: 10.1038/clpt.2008.3. PMID: 18305452
Tutka P, Mosiewicz J, Wielosz M
Pharmacol Rep 2005 Mar-Apr;57(2):143-53. PMID: 15886412

Therapy

Hernández-Pérez A, García-Gómez L, Robles-Hernández R, Thirión-Romero I, Osio-Echánove J, Rodríguez-Llamazares S, Baler R, Pérez-Padilla R
Rev Invest Clin 2023;75(3):158-168. doi: 10.24875/RIC.23000117. PMID: 37441760
Zhang Q, Wen C
Front Public Health 2023;11:1146949. Epub 2023 May 15 doi: 10.3389/fpubh.2023.1146949. PMID: 37255760Free PMC Article
Bernat D, Gasquet N, Wilson KO, Porter L, Choi K
Am J Prev Med 2018 Sep;55(3):361-367. Epub 2018 Jul 19 doi: 10.1016/j.amepre.2018.04.043. PMID: 30031636Free PMC Article
Changeux JP
C R Biol 2009 May;332(5):421-5. Epub 2009 Mar 20 doi: 10.1016/j.crvi.2009.02.005. PMID: 19393973
Kaye FJ
Lung Cancer 2001 Dec;34 Suppl 2:S35-41. doi: 10.1016/s0169-5002(01)00342-7. PMID: 11720739

Prognosis

Saunders GRB, Wang X, Chen F, Jang SK, Liu M, Wang C, Gao S, Jiang Y, Khunsriraksakul C, Otto JM, Addison C, Akiyama M, Albert CM, Aliev F, Alonso A, Arnett DK, Ashley-Koch AE, Ashrani AA, Barnes KC, Barr RG, Bartz TM, Becker DM, Bielak LF, Benjamin EJ, Bis JC, Bjornsdottir G, Blangero J, Bleecker ER, Boardman JD, Boerwinkle E, Boomsma DI, Boorgula MP, Bowden DW, Brody JA, Cade BE, Chasman DI, Chavan S, Chen YI, Chen Z, Cheng I, Cho MH, Choquet H, Cole JW, Cornelis MC, Cucca F, Curran JE, de Andrade M, Dick DM, Docherty AR, Duggirala R, Eaton CB, Ehringer MA, Esko T, Faul JD, Fernandes Silva L, Fiorillo E, Fornage M, Freedman BI, Gabrielsen ME, Garrett ME, Gharib SA, Gieger C, Gillespie N, Glahn DC, Gordon SD, Gu CC, Gu D, Gudbjartsson DF, Guo X, Haessler J, Hall ME, Haller T, Harris KM, He J, Herd P, Hewitt JK, Hickie I, Hidalgo B, Hokanson JE, Hopfer C, Hottenga J, Hou L, Huang H, Hung YJ, Hunter DJ, Hveem K, Hwang SJ, Hwu CM, Iacono W, Irvin MR, Jee YH, Johnson EO, Joo YY, Jorgenson E, Justice AE, Kamatani Y, Kaplan RC, Kaprio J, Kardia SLR, Keller MC, Kelly TN, Kooperberg C, Korhonen T, Kraft P, Krauter K, Kuusisto J, Laakso M, Lasky-Su J, Lee WJ, Lee JJ, Levy D, Li L, Li K, Li Y, Lin K, Lind PA, Liu C, Lloyd-Jones DM, Lutz SM, Ma J, Mägi R, Manichaikul A, Martin NG, Mathur R, Matoba N, McArdle PF, McGue M, McQueen MB, Medland SE, Metspalu A, Meyers DA, Millwood IY, Mitchell BD, Mohlke KL, Moll M, Montasser ME, Morrison AC, Mulas A, Nielsen JB, North KE, Oelsner EC, Okada Y, Orrù V, Palmer ND, Palviainen T, Pandit A, Park SL, Peters U, Peters A, Peyser PA, Polderman TJC, Rafaels N, Redline S, Reed RM, Reiner AP, Rice JP, Rich SS, Richmond NE, Roan C, Rotter JI, Rueschman MN, Runarsdottir V, Saccone NL, Schwartz DA, Shadyab AH, Shi J, Shringarpure SS, Sicinski K, Skogholt AH, Smith JA, Smith NL, Sotoodehnia N, Stallings MC, Stefansson H, Stefansson K, Stitzel JA, Sun X, Syed M, Tal-Singer R, Taylor AE, Taylor KD, Telen MJ, Thai KK, Tiwari H, Turman C, Tyrfingsson T, Wall TL, Walters RG, Weir DR, Weiss ST, White WB, Whitfield JB, Wiggins KL, Willemsen G, Willer CJ, Winsvold BS, Xu H, Yanek LR, Yin J, Young KL, Young KA, Yu B, Zhao W, Zhou W, Zöllner S, Zuccolo L; 23andMe Research Team; Biobank Japan Project, Batini C, Bergen AW, Bierut LJ, David SP, Gagliano Taliun SA, Hancock DB, Jiang B, Munafò MR, Thorgeirsson TE, Liu DJ, Vrieze S
Nature 2022 Dec;612(7941):720-724. Epub 2022 Dec 7 doi: 10.1038/s41586-022-05477-4. PMID: 36477530Free PMC Article
Ford PJ, Rich AM
Addiction 2021 Dec;116(12):3531-3540. Epub 2021 Apr 25 doi: 10.1111/add.15513. PMID: 33822437
Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K
Transl Psychiatry 2015 Oct 6;5(10):e651. doi: 10.1038/tp.2015.149. PMID: 26440539Free PMC Article
Harv Ment Health Lett 2010 Jan;26(7):1-3. PMID: 20213932
Kaye FJ
Lung Cancer 2001 Dec;34 Suppl 2:S35-41. doi: 10.1016/s0169-5002(01)00342-7. PMID: 11720739

Clinical prediction guides

Saleh EA, Lazaridou FB, Klapprott F, Wazaify M, Heinz A, Kluge U
Addiction 2023 Feb;118(2):218-253. Epub 2022 Sep 5 doi: 10.1111/add.16021. PMID: 35929580
Saunders GRB, Wang X, Chen F, Jang SK, Liu M, Wang C, Gao S, Jiang Y, Khunsriraksakul C, Otto JM, Addison C, Akiyama M, Albert CM, Aliev F, Alonso A, Arnett DK, Ashley-Koch AE, Ashrani AA, Barnes KC, Barr RG, Bartz TM, Becker DM, Bielak LF, Benjamin EJ, Bis JC, Bjornsdottir G, Blangero J, Bleecker ER, Boardman JD, Boerwinkle E, Boomsma DI, Boorgula MP, Bowden DW, Brody JA, Cade BE, Chasman DI, Chavan S, Chen YI, Chen Z, Cheng I, Cho MH, Choquet H, Cole JW, Cornelis MC, Cucca F, Curran JE, de Andrade M, Dick DM, Docherty AR, Duggirala R, Eaton CB, Ehringer MA, Esko T, Faul JD, Fernandes Silva L, Fiorillo E, Fornage M, Freedman BI, Gabrielsen ME, Garrett ME, Gharib SA, Gieger C, Gillespie N, Glahn DC, Gordon SD, Gu CC, Gu D, Gudbjartsson DF, Guo X, Haessler J, Hall ME, Haller T, Harris KM, He J, Herd P, Hewitt JK, Hickie I, Hidalgo B, Hokanson JE, Hopfer C, Hottenga J, Hou L, Huang H, Hung YJ, Hunter DJ, Hveem K, Hwang SJ, Hwu CM, Iacono W, Irvin MR, Jee YH, Johnson EO, Joo YY, Jorgenson E, Justice AE, Kamatani Y, Kaplan RC, Kaprio J, Kardia SLR, Keller MC, Kelly TN, Kooperberg C, Korhonen T, Kraft P, Krauter K, Kuusisto J, Laakso M, Lasky-Su J, Lee WJ, Lee JJ, Levy D, Li L, Li K, Li Y, Lin K, Lind PA, Liu C, Lloyd-Jones DM, Lutz SM, Ma J, Mägi R, Manichaikul A, Martin NG, Mathur R, Matoba N, McArdle PF, McGue M, McQueen MB, Medland SE, Metspalu A, Meyers DA, Millwood IY, Mitchell BD, Mohlke KL, Moll M, Montasser ME, Morrison AC, Mulas A, Nielsen JB, North KE, Oelsner EC, Okada Y, Orrù V, Palmer ND, Palviainen T, Pandit A, Park SL, Peters U, Peters A, Peyser PA, Polderman TJC, Rafaels N, Redline S, Reed RM, Reiner AP, Rice JP, Rich SS, Richmond NE, Roan C, Rotter JI, Rueschman MN, Runarsdottir V, Saccone NL, Schwartz DA, Shadyab AH, Shi J, Shringarpure SS, Sicinski K, Skogholt AH, Smith JA, Smith NL, Sotoodehnia N, Stallings MC, Stefansson H, Stefansson K, Stitzel JA, Sun X, Syed M, Tal-Singer R, Taylor AE, Taylor KD, Telen MJ, Thai KK, Tiwari H, Turman C, Tyrfingsson T, Wall TL, Walters RG, Weir DR, Weiss ST, White WB, Whitfield JB, Wiggins KL, Willemsen G, Willer CJ, Winsvold BS, Xu H, Yanek LR, Yin J, Young KL, Young KA, Yu B, Zhao W, Zhou W, Zöllner S, Zuccolo L; 23andMe Research Team; Biobank Japan Project, Batini C, Bergen AW, Bierut LJ, David SP, Gagliano Taliun SA, Hancock DB, Jiang B, Munafò MR, Thorgeirsson TE, Liu DJ, Vrieze S
Nature 2022 Dec;612(7941):720-724. Epub 2022 Dec 7 doi: 10.1038/s41586-022-05477-4. PMID: 36477530Free PMC Article
Al-Soufi L, Martorell L, Moltó MD, González-Peñas J, García-Portilla MP, Arrojo M, Rivero O, Gutiérrez-Zotes A, Nácher J, Muntané G, Paz E, Páramo M, Bobes J, Arango C, Sanjuan J, Vilella E, Costas J
Addict Biol 2022 Jan;27(1):e13104. Epub 2021 Nov 14 doi: 10.1111/adb.13104. PMID: 34779080
Park SJ, Yi B, Lee HS, Oh WY, Na HK, Lee M, Yang M
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(1):33-56. doi: 10.1080/10590501.2015.1131539. PMID: 26669465
Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K
Transl Psychiatry 2015 Oct 6;5(10):e651. doi: 10.1038/tp.2015.149. PMID: 26440539Free PMC Article

Recent systematic reviews

Rutherford BN, Lim CCW, Cheng B, Sun T, Vu GT, Johnson B, Daniel Paul Ashley, Chung J, Huang S, Leung J, Stjepanović D, Connor JP, Chan GCK
Addict Behav 2023 Dec;147:107828. Epub 2023 Aug 6 doi: 10.1016/j.addbeh.2023.107828. PMID: 37591107
Saleh EA, Lazaridou FB, Klapprott F, Wazaify M, Heinz A, Kluge U
Addiction 2023 Feb;118(2):218-253. Epub 2022 Sep 5 doi: 10.1111/add.16021. PMID: 35929580
Chang XW, Sun Y, Muhai JN, Li YY, Chen Y, Lu L, Chang SH, Shi J
Addiction 2022 Sep;117(9):2515-2529. Epub 2022 May 10 doi: 10.1111/add.15908. PMID: 35491750
Park SJ, Yi B, Lee HS, Oh WY, Na HK, Lee M, Yang M
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(1):33-56. doi: 10.1080/10590501.2015.1131539. PMID: 26669465
Sharan RN, Mehrotra R, Choudhury Y, Asotra K
PLoS One 2012;7(8):e42759. Epub 2012 Aug 13 doi: 10.1371/journal.pone.0042759. PMID: 22912735Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG209, Tobacco: preventing uptake, promoting quitting and treating dependence, 2023

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