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Ezetimibe response

MedGen UID:
334236
Concept ID:
C1842722
Finding
Synonym: EZETIMIBE, NONRESPONSE TO
Drug:
Ezetimibe
MedGen UID:
256233
Concept ID:
C1142985
Pharmacologic Substance
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. [from NCI]
 
OMIM®: 608010

Professional guidelines

PubMed

Writing Committee, Lloyd-Jones DM, Morris PB, Ballantyne CM, Birtcher KK, Covington AM, DePalma SM, Minissian MB, Orringer CE, Smith SC Jr, Waring AA, Wilkins JT
J Am Coll Cardiol 2022 Oct 4;80(14):1366-1418. Epub 2022 Aug 25 doi: 10.1016/j.jacc.2022.07.006. PMID: 36031461
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Karr S
Am J Manag Care 2017 Jun;23(9 Suppl):S139-S148. PMID: 28978219

Curated

DailyMed Drug Label, EZETIMIBE, 2021

DailyMed Drug Label, ezetimibe, 2013

Recent clinical studies

Etiology

Sodum N, Kumar G, Bojja SL, Kumar N, Rao CM
Pharmacol Res 2021 May;167:105484. Epub 2021 Mar 24 doi: 10.1016/j.phrs.2021.105484. PMID: 33771699
Gallego-Colon E, Daum A, Yosefy C
Eur J Pharmacol 2020 Jul 5;878:173114. Epub 2020 Apr 14 doi: 10.1016/j.ejphar.2020.173114. PMID: 32302598
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Karr S
Am J Manag Care 2017 Jun;23(9 Suppl):S139-S148. PMID: 28978219
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634

Diagnosis

Cha JJ, Hong SJ, Kim JH, Lim S, Joo HJ, Park JH, Yu CW, Lee PH, Lee SW, Lee CW, Moon JY, Lee JY, Kim JS, Park JS, Lee K, Lim SY, Na JO, Cho JM, Kim SY, Lim DS
Am Heart J 2023 Jul;261:45-50. Epub 2023 Mar 17 doi: 10.1016/j.ahj.2023.03.002. PMID: 36934981
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Tsujita K, Sugiyama S, Sumida H, Shimomura H, Yamashita T, Yamanaga K, Komura N, Sakamoto K, Oka H, Nakao K, Nakamura S, Ishihara M, Matsui K, Sakaino N, Nakamura N, Yamamoto N, Koide S, Matsumura T, Fujimoto K, Tsunoda R, Morikami Y, Matsuyama K, Oshima S, Kaikita K, Hokimoto S, Ogawa H; PRECISE–IVUS Investigators
J Am Coll Cardiol 2015 Aug 4;66(5):495-507. doi: 10.1016/j.jacc.2015.05.065. PMID: 26227186
Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, Wanner C, Krane V, Cass A, Craig J, Neal B, Jiang L, Hooi LS, Levin A, Agodoa L, Gaziano M, Kasiske B, Walker R, Massy ZA, Feldt-Rasmussen B, Krairittichai U, Ophascharoensuk V, Fellström B, Holdaas H, Tesar V, Wiecek A, Grobbee D, de Zeeuw D, Grönhagen-Riska C, Dasgupta T, Lewis D, Herrington W, Mafham M, Majoni W, Wallendszus K, Grimm R, Pedersen T, Tobert J, Armitage J, Baxter A, Bray C, Chen Y, Chen Z, Hill M, Knott C, Parish S, Simpson D, Sleight P, Young A, Collins R; SHARP Investigators
Lancet 2011 Jun 25;377(9784):2181-92. Epub 2011 Jun 12 doi: 10.1016/S0140-6736(11)60739-3. PMID: 21663949Free PMC Article
Ashikaga H, Blumenthal RS, Jones SR
Am J Cardiol 2009 May 1;103(9):1321-2. Epub 2009 Mar 5 doi: 10.1016/j.amjcard.2009.01.019. PMID: 19406279

Therapy

Lee C, Kwak SH, Han J, Shin JH, Yoo B, Lee YS, Park JS, Lim BJ, Lee JG, Kim YS, Kim SY, Bae SH
Eur Respir J 2024 May;63(5) Epub 2024 May 16 doi: 10.1183/13993003.00580-2023. PMID: 38359963Free PMC Article
Nair T
Indian Heart J 2024 Mar;76 Suppl 1(Suppl 1):S44-S50. Epub 2024 Jan 7 doi: 10.1016/j.ihj.2023.12.011. PMID: 38195006Free PMC Article
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Dimmitt SB, Stampfer HG, Warren JB
Br J Clin Pharmacol 2018 Jun;84(6):1128-1135. Epub 2018 Apr 16 doi: 10.1111/bcp.13539. PMID: 29393975Free PMC Article
Karr S
Am J Manag Care 2017 Jun;23(9 Suppl):S139-S148. PMID: 28978219

Prognosis

Tarugi P, Bertolini S, Calandra S, Arca M, Angelico F, Casula M, Cefalù AB, D'Erasmo L, Fortunato G, Perrone-Filardi P, Rubba P, Suppressa P, Averna M, Catapano AL
Nutr Metab Cardiovasc Dis 2024 Aug;34(8):1819-1836. Epub 2024 May 7 doi: 10.1016/j.numecd.2024.05.002. PMID: 38871496
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, Wanner C, Krane V, Cass A, Craig J, Neal B, Jiang L, Hooi LS, Levin A, Agodoa L, Gaziano M, Kasiske B, Walker R, Massy ZA, Feldt-Rasmussen B, Krairittichai U, Ophascharoensuk V, Fellström B, Holdaas H, Tesar V, Wiecek A, Grobbee D, de Zeeuw D, Grönhagen-Riska C, Dasgupta T, Lewis D, Herrington W, Mafham M, Majoni W, Wallendszus K, Grimm R, Pedersen T, Tobert J, Armitage J, Baxter A, Bray C, Chen Y, Chen Z, Hill M, Knott C, Parish S, Simpson D, Sleight P, Young A, Collins R; SHARP Investigators
Lancet 2011 Jun 25;377(9784):2181-92. Epub 2011 Jun 12 doi: 10.1016/S0140-6736(11)60739-3. PMID: 21663949Free PMC Article
Sharp Collaborative Group
Am Heart J 2010 Nov;160(5):785-794.e10. Epub 2010 Sep 18 doi: 10.1016/j.ahj.2010.08.012. PMID: 21095263
Ashikaga H, Blumenthal RS, Jones SR
Am J Cardiol 2009 May 1;103(9):1321-2. Epub 2009 Mar 5 doi: 10.1016/j.amjcard.2009.01.019. PMID: 19406279

Clinical prediction guides

Lee C, Kwak SH, Han J, Shin JH, Yoo B, Lee YS, Park JS, Lim BJ, Lee JG, Kim YS, Kim SY, Bae SH
Eur Respir J 2024 May;63(5) Epub 2024 May 16 doi: 10.1183/13993003.00580-2023. PMID: 38359963Free PMC Article
Cha JJ, Hong SJ, Kim JH, Lim S, Joo HJ, Park JH, Yu CW, Lee PH, Lee SW, Lee CW, Moon JY, Lee JY, Kim JS, Park JS, Lee K, Lim SY, Na JO, Cho JM, Kim SY, Lim DS
Am Heart J 2023 Jul;261:45-50. Epub 2023 Mar 17 doi: 10.1016/j.ahj.2023.03.002. PMID: 36934981
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Tiwari V, Khokhar M
Eur J Pharmacol 2014 Oct 15;741:156-70. Epub 2014 Aug 21 doi: 10.1016/j.ejphar.2014.07.048. PMID: 25151024
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634

Recent systematic reviews

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

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