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Alzheimer disease, late-onset, susceptibility to

MedGen UID:
320276
Concept ID:
C1834153
Finding
Synonym: ALZHEIMER DISEASE, LATE-ONSET, SUSCEPTIBILITY TO
 
OMIM®: 163729; 191840

Professional guidelines

PubMed

Nicolas G, Zaréa A, Lacour M, Quenez O, Rousseau S, Richard AC, Bonnevalle A, Schramm C, Olaso R, Sandron F, Boland A, Deleuze JF, Andriuta D, Anthony P, Auriacombe S, Balageas AC, Ballan G, Barbay M, Béjot Y, Belliard S, Benaiteau M, Bennys K, Bombois S, Boutoleau-Bretonnière C, Branger P, Carlier J, Cartz-Piver L, Cassagnaud P, Ceccaldi MP, Chauviré V, Chen Y, Cogez J, Cognat E, Contegal-Callier F, Corneille L, Couratier P, Cretin B, Crinquette C, Dauriat B, Dautricourt S, de la Sayette V, de Liège A, Deffond D, Demurger F, Deramecourt V, Derollez C, Dionet E, Doco Fenzy M, Dumurgier J, Dutray A, Etcharry-Bouyx F, Formaglio M, Gabelle A, Gainche-Salmon A, Godefroy O, Graber M, Gregoire C, Grimaldi S, Gueniat J, Gueriot C, Guillet-Pichon V, Haffen S, Hanta CR, Hardy C, Hautecloque G, Heitz C, Hourregue C, Jonveaux T, Jurici S, Koric L, Krolak-Salmon P, Lagarde J, Lanoiselée HM, Laurens B, Le Ber I, Le Guyader G, Leblanc A, Lebouvier T, Levy R, Lippi A, Mackowiak MA, Magnin E, Marelli C, Martinaud O, Maureille A, Migliaccio R, Milongo-Rigal E, Mohr S, Mollion H, Morin A, Nivelle J, Noiray C, Olivieri P, Paquet C, Pariente J, Pasquier F, Perron A, Philippi N, Planche V, Pouclet-Courtemanche H, Rafiq M, Rollin-Sillaire A, Roué-Jagot C, Saracino D, Sarazin M, Sauvée M, Sellal F, Teichmann M, Thauvin C, Thomas Q, Tisserand C, Turpinat C, Van Damme L, Vercruysse O, Villain N, Wagemann N, Charbonnier C, Wallon D
Genet Med 2024 May;26(5):101082. Epub 2024 Jan 24 doi: 10.1016/j.gim.2024.101082. PMID: 38281098
Manrique de Lara A, Soto-Gómez L, Núñez-Acosta E, Saruwatari-Zavala G, Rentería ME
Am J Med Genet B Neuropsychiatr Genet 2019 Dec;180(8):609-621. Epub 2018 Dec 7 doi: 10.1002/ajmg.b.32699. PMID: 30525300
Verlinsky Y, Kuliev A
Expert Rev Mol Diagn 2002 Sep;2(5):509-13. doi: 10.1586/14737159.2.5.509. PMID: 12271822

Recent clinical studies

Etiology

Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G
Nat Rev Neurol 2019 Sep;15(9):501-518. Epub 2019 Jul 31 doi: 10.1038/s41582-019-0228-7. PMID: 31367008Free PMC Article
Serrano-Pozo A, Growdon JH
J Alzheimers Dis 2019;67(3):795-819. doi: 10.3233/JAD181028. PMID: 30776012Free PMC Article
Guimas Almeida C, Sadat Mirfakhar F, Perdigão C, Burrinha T
Cell Mol Life Sci 2018 Jul;75(14):2577-2589. Epub 2018 Apr 27 doi: 10.1007/s00018-018-2825-9. PMID: 29704008Free PMC Article
Karch CM, Goate AM
Biol Psychiatry 2015 Jan 1;77(1):43-51. Epub 2014 May 17 doi: 10.1016/j.biopsych.2014.05.006. PMID: 24951455Free PMC Article
Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P
Nat Genet 2013 Dec;45(12):1452-8. Epub 2013 Oct 27 doi: 10.1038/ng.2802. PMID: 24162737Free PMC Article

Diagnosis

Devanand DP, Jeste DV, Stroup TS, Goldberg TE
Int Psychogeriatr 2024 Jan;36(1):28-42. Epub 2023 Mar 3 doi: 10.1017/S1041610223000157. PMID: 36866576
Jayadev S
Continuum (Minneap Minn) 2022 Jun 1;28(3):852-871. doi: 10.1212/CON.0000000000001125. PMID: 35678406
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Saba Y, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, C O'Donovan M, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA; Alzheimer Disease Genetics Consortium (ADGC),; European Alzheimer’s Disease Initiative (EADI),; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),; Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),
Nat Genet 2019 Mar;51(3):414-430. Epub 2019 Feb 28 doi: 10.1038/s41588-019-0358-2. PMID: 30820047Free PMC Article
Guimas Almeida C, Sadat Mirfakhar F, Perdigão C, Burrinha T
Cell Mol Life Sci 2018 Jul;75(14):2577-2589. Epub 2018 Apr 27 doi: 10.1007/s00018-018-2825-9. PMID: 29704008Free PMC Article
Ritchie K, Lovestone S
Lancet 2002 Nov 30;360(9347):1759-66. doi: 10.1016/S0140-6736(02)11667-9. PMID: 12480441

Therapy

Huang H, Ren Y, Wang J, Zhang Z, Zhou J, Chang S, Zhang Y, Xue J
Ren Fail 2024 Dec;46(2):2411856. Epub 2024 Oct 16 doi: 10.1080/0886022X.2024.2411856. PMID: 39412044Free PMC Article
Zhai M, Zhang Y, Yan D, Wang Y, Li W, Sun J
J Alzheimers Dis 2024;98(3):885-896. doi: 10.3233/JAD-230985. PMID: 38489174
Devanand DP, Jeste DV, Stroup TS, Goldberg TE
Int Psychogeriatr 2024 Jan;36(1):28-42. Epub 2023 Mar 3 doi: 10.1017/S1041610223000157. PMID: 36866576
Bales KR, Paul SM
Neurosci Lett 2019 Sep 14;709:134366. Epub 2019 Jul 20 doi: 10.1016/j.neulet.2019.134366. PMID: 31336138
Ritchie K, Lovestone S
Lancet 2002 Nov 30;360(9347):1759-66. doi: 10.1016/S0140-6736(02)11667-9. PMID: 12480441

Prognosis

Devanand DP, Jeste DV, Stroup TS, Goldberg TE
Int Psychogeriatr 2024 Jan;36(1):28-42. Epub 2023 Mar 3 doi: 10.1017/S1041610223000157. PMID: 36866576
Jayadev S
Continuum (Minneap Minn) 2022 Jun 1;28(3):852-871. doi: 10.1212/CON.0000000000001125. PMID: 35678406
Kamboh MI
Neurotherapeutics 2022 Jan;19(1):152-172. Epub 2021 Dec 21 doi: 10.1007/s13311-021-01152-0. PMID: 34935119Free PMC Article
Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS
Top Magn Reson Imaging 2019 Dec;28(6):325-334. doi: 10.1097/RMR.0000000000000222. PMID: 31794505
Piaceri I, Nacmias B, Sorbi S
Front Biosci (Elite Ed) 2013 Jan 1;5(1):167-77. doi: 10.2741/e605. PMID: 23276979

Clinical prediction guides

Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW
Alzheimers Dement 2024 Jul;20(7):4970-4984. Epub 2024 Apr 30 doi: 10.1002/alz.13840. PMID: 38687251Free PMC Article
Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS
Top Magn Reson Imaging 2019 Dec;28(6):325-334. doi: 10.1097/RMR.0000000000000222. PMID: 31794505
Nikolac Perkovic M, Pivac N
Adv Exp Med Biol 2019;1192:27-52. doi: 10.1007/978-981-32-9721-0_3. PMID: 31705489
Hardy J, Escott-Price V
Hum Mol Genet 2019 Nov 21;28(R2):R235-R240. doi: 10.1093/hmg/ddz163. PMID: 31332445
Piaceri I, Nacmias B, Sorbi S
Front Biosci (Elite Ed) 2013 Jan 1;5(1):167-77. doi: 10.2741/e605. PMID: 23276979

Recent systematic reviews

Zuin M, Cervellati C, Trentini A, Roncon L, Guasti P, Zuliani G
Minerva Med 2021 Jun;112(3):365-371. Epub 2020 Jul 22 doi: 10.23736/S0026-4806.20.06801-9. PMID: 32700867
Harrison JR, Mistry S, Muskett N, Escott-Price V
J Alzheimers Dis 2020;74(4):1271-1283. doi: 10.3233/JAD-191233. PMID: 32250305Free PMC Article
Andrews SJ, McFall GP, Booth A, Dixon RA, Anstey KJ
J Alzheimers Dis 2019;69(4):1109-1136. doi: 10.3233/JAD-190342. PMID: 31156182
Talwar P, Sinha J, Grover S, Rawat C, Kushwaha S, Agarwal R, Taneja V, Kukreti R
Mol Neurobiol 2016 Sep;53(7):4833-64. Epub 2015 Sep 9 doi: 10.1007/s12035-015-9390-0. PMID: 26351077
Di Bona D, Rizzo C, Bonaventura G, Candore G, Caruso C
J Alzheimers Dis 2012;29(4):751-9. doi: 10.3233/JAD-2012-111838. PMID: 22356904

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