U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Relapsing remitting multiple sclerosis

MedGen UID:
155669
Concept ID:
C0751967
Disease or Syndrome
Synonyms: Multiple Sclerosis, Relapsing Remitting; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis, Remitting-Relapsing; Relapsing Remitting Multiple Sclerosis; Relapsing-Remitting Multiple Sclerosis; Remitting Relapsing Multiple Sclerosis; Remitting-Relapsing Multiple Sclerosis
SNOMED CT: Relapsing remitting multiple sclerosis (426373005); Multiple sclerosis (MS) relapsing remitting (426373005)
 
Monarch Initiative: MONDO:0005314

Definition

A type of multiple sclerosis characterized by intermittent flare-ups with a return to few or no symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRelapsing remitting multiple sclerosis

Professional guidelines

PubMed

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Correale J, Gaitán MI, Ysrraelit MC, Fiol MP
Brain 2017 Mar 1;140(3):527-546. doi: 10.1093/brain/aww258. PMID: 27794524
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Svenningsson A, Frisell T, Burman J, Salzer J, Fink K, Hallberg S, Hambraeus J, Axelsson M, Nimer FA, Sundström P, Gunnarsson M, Johansson R, Mellergård J, Rosenstein I, Ayad A, Sjöblom I, Risedal A, de Flon P, Gilland E, Lindeberg J, Shawket F, Piehl F, Lycke J
Lancet Neurol 2022 Aug;21(8):693-703. doi: 10.1016/S1474-4422(22)00209-5. PMID: 35841908
Kaegi C, Wuest B, Crowley C, Boyman O
Front Immunol 2021;12:788830. Epub 2022 Feb 2 doi: 10.3389/fimmu.2021.788830. PMID: 35185862Free PMC Article
Fiander MDJ, Bhan V, Stewart SA, Parks NE
Can J Neurol Sci 2019 Jul;46(4):455-458. Epub 2019 May 22 doi: 10.1017/cjn.2019.42. PMID: 31113500
Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, Rieckmann P, Comi G, Dangond F, Adeniji AK, Vermersch P
Mult Scler 2018 Oct;24(12):1594-1604. Epub 2017 Sep 5 doi: 10.1177/1352458517727603. PMID: 28870107
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Diagnosis

Freeman L, Longbrake EE, Coyle PK, Hendin B, Vollmer T
CNS Drugs 2022 Dec;36(12):1285-1299. Epub 2022 Nov 9 doi: 10.1007/s40263-022-00965-7. PMID: 36350491Free PMC Article
Olek MJ
Ann Intern Med 2021 Jun;174(6):ITC81-ITC96. Epub 2021 Jun 8 doi: 10.7326/AITC202106150. PMID: 34097429
Bisulca J, De Lury A, Coyle PK, Syritsyna O, Peyster R, Bangiyev L, Duong TQ
Mult Scler Relat Disord 2019 Nov;36:101381. Epub 2019 Sep 2 doi: 10.1016/j.msard.2019.101381. PMID: 31518773
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Klotz L, Antel J, Kuhlmann T
Nat Rev Neurol 2023 May;19(5):305-320. Epub 2023 Apr 14 doi: 10.1038/s41582-023-00801-6. PMID: 37059811
Diaz RA, Doss S, Burke MJ, George E, Adler AI
Lancet Neurol 2014 Sep;13(9):869-70. doi: 10.1016/s1474-4422(14)70184-x. PMID: 25285344
Sorensen PS
Lancet Neurol 2014 Jun;13(6):526-7. Epub 2014 Mar 28 doi: 10.1016/S1474-4422(14)70067-5. PMID: 24685277
Giovannoni G, Comi G, Cook S, Rammohan K, Rieckmann P, Soelberg Sørensen P, Vermersch P, Chang P, Hamlett A, Musch B, Greenberg SJ; CLARITY Study Group
N Engl J Med 2010 Feb 4;362(5):416-26. Epub 2010 Jan 20 doi: 10.1056/NEJMoa0902533. PMID: 20089960
Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, Bar-Or A, Panzara M, Sarkar N, Agarwal S, Langer-Gould A, Smith CH; HERMES Trial Group
N Engl J Med 2008 Feb 14;358(7):676-88. doi: 10.1056/NEJMoa0706383. PMID: 18272891

Prognosis

Kvistad CE, Lehmann AK, Kvistad SAS, Holmøy T, Lorentzen ÅR, Trovik LH, Kristoffersen EK, Bø L, Torkildsen Ø
Mult Scler 2024 May;30(6):751-754. Epub 2024 Feb 12 doi: 10.1177/13524585241231665. PMID: 38345003Free PMC Article
He A, Merkel B, Brown JWL, Zhovits Ryerson L, Kister I, Malpas CB, Sharmin S, Horakova D, Kubala Havrdova E, Spelman T, Izquierdo G, Eichau S, Trojano M, Lugaresi A, Hupperts R, Sola P, Ferraro D, Lycke J, Grand'Maison F, Prat A, Girard M, Duquette P, Larochelle C, Svenningsson A, Petersen T, Grammond P, Granella F, Van Pesch V, Bergamaschi R, McGuigan C, Coles A, Hillert J, Piehl F, Butzkueven H, Kalincik T; MSBase study group
Lancet Neurol 2020 Apr;19(4):307-316. Epub 2020 Mar 18 doi: 10.1016/S1474-4422(20)30067-3. PMID: 32199096
Fiander MDJ, Bhan V, Stewart SA, Parks NE
Can J Neurol Sci 2019 Jul;46(4):455-458. Epub 2019 May 22 doi: 10.1017/cjn.2019.42. PMID: 31113500
Bar-Or A, Grove RA, Austin DJ, Tolson JM, VanMeter SA, Lewis EW, Derosier FJ, Lopez MC, Kavanagh ST, Miller AE, Sorensen PS
Neurology 2018 May 15;90(20):e1805-e1814. Epub 2018 Apr 25 doi: 10.1212/WNL.0000000000005516. PMID: 29695594Free PMC Article
Río J, Auger C, Rovira À
Neuroimaging Clin N Am 2017 May;27(2):277-287. Epub 2017 Feb 14 doi: 10.1016/j.nic.2017.01.001. PMID: 28391786

Clinical prediction guides

Sharmin S, Roos I, Malpas CB, Iaffaldano P, Simone M, Filippi M, Kubala Havrdova E, Ozakbas S, Brescia Morra V, Alroughani R, Zaffaroni M, Patti F, Eichau S, Salemi G, Di Sapio A, Inglese M, Portaccio E, Trojano M, Amato MP, Kalincik T; Writing Group; Italian Multiple Sclerosis and Related Disorders Register and MSBase Study Group
Lancet Child Adolesc Health 2024 May;8(5):348-357. Epub 2024 Mar 25 doi: 10.1016/S2352-4642(24)00047-6. PMID: 38547883
Spelman T, Horakova D, Ozakbas S, Alroughani R, Onofrj M, Kalincik T, Prat A, Terzi M, Grammond P, Patti F, Csepany T, Boz C, Lechner-Scott J, Granella F, Grand'Maison F, van der Walt A, Zhu C, Butzkueven H; MSBase Study Group
Mult Scler Relat Disord 2023 Feb;70:104477. Epub 2022 Dec 23 doi: 10.1016/j.msard.2022.104477. PMID: 36746088
Rosenstein I, Axelsson M, Novakova L, Rasch S, Blennow K, Zetterberg H, Lycke J
Front Immunol 2023;14:1106028. Epub 2023 Jan 20 doi: 10.3389/fimmu.2023.1106028. PMID: 36742305Free PMC Article
Spelman T, Magyari M, Piehl F, Svenningsson A, Rasmussen PV, Kant M, Sellebjerg F, Joensen H, Hillert J, Lycke J
JAMA Neurol 2021 Oct 1;78(10):1197-1204. doi: 10.1001/jamaneurol.2021.2738. PMID: 34398221Free PMC Article
Río J, Auger C, Rovira À
Neuroimaging Clin N Am 2017 May;27(2):277-287. Epub 2017 Feb 14 doi: 10.1016/j.nic.2017.01.001. PMID: 28391786

Recent systematic reviews

Gonzalez-Lorenzo M, Ridley B, Minozzi S, Del Giovane C, Peryer G, Piggott T, Foschi M, Filippini G, Tramacere I, Baldin E, Nonino F
Cochrane Database Syst Rev 2024 Jan 4;1(1):CD011381. doi: 10.1002/14651858.CD011381.pub3. PMID: 38174776Free PMC Article
Müller J, Cagol A, Lorscheider J, Tsagkas C, Benkert P, Yaldizli Ö, Kuhle J, Derfuss T, Sormani MP, Thompson A, Granziera C, Kappos L
JAMA Neurol 2023 Nov 1;80(11):1232-1245. doi: 10.1001/jamaneurol.2023.3331. PMID: 37782515
Śladowska K, Kawalec P, Holko P, Osiecka O
Neurol Sci 2022 Sep;43(9):5479-5500. Epub 2022 Jun 17 doi: 10.1007/s10072-022-06197-3. PMID: 35713731
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...