U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Progressive spastic paraparesis

MedGen UID:
488935
•Concept ID:
C0747251
•
Sign or Symptom
HPO: HP:0007199

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Progressive spastic paraparesis

Professional guidelines

PubMed

Management of spinal dural arterio-venous fistulas. Report of 12 cases and review of literature.
Rashad S, Abdel-Bary M, Aziz W, Hassan T
Clin Neurol Neurosurg 2014 Oct;125:81-6. Epub 2014 Jul 27 doi: 10.1016/j.clineuro.2014.07.028. PMID: 25108697
Progressive spastic paraparesis: hereditary spastic paraplegia and its relation to primary and amyotrophic lateral sclerosis.
Fink JK
Semin Neurol 2001 Jun;21(2):199-207. doi: 10.1055/s-2001-15265. PMID: 11442328
Differential diagnosis of progressive spastic paraparesis.
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480

Recent clinical studies

Etiology

White matter abnormalities in 15 subjects with SPG76.
Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Spinal angiolipoma: case report and literature review.
Hungs M, Paré LS
J Spinal Cord Med 2008;31(3):315-8. doi: 10.1080/10790268.2008.11760731. PMID: 18795485Free PMC Article
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Sarcoidosis and HTLV-1 infection.
McKee DH, Young AC, Haeney M
J Clin Pathol 2005 Sep;58(9):996-7. doi: 10.1136/jcp.2004.022715. PMID: 16126888Free PMC Article

Diagnosis

Progressive spastic paraparesis in a girl with short stature.
Sharawat IK, Suthar R, Sankhyan N, Singhi P
BMJ Case Rep 2019 May 31;12(5) doi: 10.1136/bcr-2019-230569. PMID: 31154352Free PMC Article
Adult-onset spastic paraparesis: an approach to diagnostic work-up.
Zhovtis Ryerson L, Herbert J, Howard J, Kister I
J Neurol Sci 2014 Nov 15;346(1-2):43-50. Epub 2014 Sep 19 doi: 10.1016/j.jns.2014.09.015. PMID: 25263600
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Idiopathic progressive spastic paraparesis.
Bird TD
JAMA 1995 Oct 18;274(15):1191. doi: 10.1001/jama.274.15.1191b. PMID: 7563498
Differential diagnosis of progressive spastic paraparesis.
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480

Therapy

Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Nozuma S, Kubota R, Jacobson S
J Neurovirol 2020 Oct;26(5):652-663. Epub 2020 Jul 23 doi: 10.1007/s13365-020-00881-w. PMID: 32705480Free PMC Article
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Management of surgical splenorenal shunt-related hepatic myelopathy with endovascular interventional techniques.
Wang MQ, Liu FY, Duan F
World J Gastroenterol 2012 Dec 21;18(47):7104-8. doi: 10.3748/wjg.v18.i47.7104. PMID: 23323015Free PMC Article
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Progressive spastic paraparesis revealing primary hyperparathyroidism.
Thomas P, Lebrun C
Neurology 1994 Jan;44(1):178-9. doi: 10.1212/wnl.44.1.178. PMID: 8290063

Prognosis

Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Autosomal-dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function.
Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, de Noordhout AM, Maré R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH, Crow YJ, Van Maldergem L
Hum Mutat 2018 Aug;39(8):1076-1080. Epub 2018 Jun 4 doi: 10.1002/humu.23554. PMID: 29782060Free PMC Article
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
The neurologic manifestations of primary HIV infection.
Haist SA
J Ky Med Assoc 1989 Feb;87(2):75-7. PMID: 2656895

Clinical prediction guides

White matter abnormalities in 15 subjects with SPG76.
Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Clinical characteristics of Taiwanese patients with Hereditary spastic paraplegia type 5.
Chou CT, Soong BW, Lin KP, Tsai YS, Jih KY, Liao YC, Lee YC
Ann Clin Transl Neurol 2020 Apr;7(4):486-496. Epub 2020 Mar 22 doi: 10.1002/acn3.51019. PMID: 32202070Free PMC Article
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...