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Skin hemangioma

MedGen UID:
151951
•Concept ID:
C0687140
•
Neoplastic Process
Synonyms: Angioma of Skin; angioma of skin; Angioma of the Skin; angioma of the skin; angiomatous naevus of skin; Hemangioma of skin; Hemangioma of Skin; hemangioma of skin; Hemangioma of the Skin; hemangioma of the skin; hemangioma of zone of skin; Skin Angioma; skin angioma; Skin Hemangioma; skin hemangioma; zone of skin hemangioma
SNOMED CT: Hemangioma of skin (93471006)
 
Monarch Initiative: MONDO:0003110

Definition

A hemangioma arising from the skin. [from NCI]

Professional guidelines

PubMed

Application of color Doppler ultrasound in the treatment of infantile hemangioma by applying timolol combined with Cynergy dual-wavelength laser : Application of color Doppler ultrasound in the treatment of infantile hemangioma.
Liang S, Li X, Wu Q, Wang B, Chen P
Lasers Med Sci 2025 Feb 18;40(1):101. doi: 10.1007/s10103-025-04356-4. PMID: 39964367
Radium treatment for hemangioma in early childhood. Reconstruction and dosimetry of treatments, 1920-1959.
Lundell M, Fürst CJ, Hedlund B, Holm LE
Acta Oncol 1990;29(5):551-6. doi: 10.3109/02841869009090049. PMID: 2206564

Recent clinical studies

Etiology

New dosimetry for childhood skin hemangioma treatments with (226)Ra needles or tubes.
Lundell M, Karlsson M, Carlsson Tedgren Å
Radiother Oncol 2015 Jul;116(1):139-42. Epub 2015 Jun 21 doi: 10.1016/j.radonc.2015.06.014. PMID: 26104976
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants.
Lundell M, Mattsson A, Karlsson P, Holmberg E, Gustafsson A, Holm LE
Radiat Res 1999 May;151(5):626-32. PMID: 10319736
Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma.
Karlsson P, Holmberg E, Lundell M, Mattsson A, Holm LE, Wallgren A
Radiat Res 1998 Sep;150(3):357-64. PMID: 9728664
Outcome of reproduction in women irradiated for skin hemangioma in infancy.
Källén B, Karlsson P, Lundell M, Wallgren A, Holm LE
Radiat Res 1998 Feb;149(2):202-8. PMID: 9457901
Risk of solid tumors after irradiation in infancy.
Lundell M, Holm LE
Acta Oncol 1995;34(6):727-34. doi: 10.3109/02841869509127179. PMID: 7576738

Diagnosis

Duplicated filum terminale in the absence of split cord malformation: a potential cause of failed detethering procedures.
Rizk E, Adeeb N, Hussein AE, Tubbs RS, Rozzelle CJ, Oakes WJ
Childs Nerv Syst 2014 Apr;30(4):709-11. Epub 2013 Jun 7 doi: 10.1007/s00381-013-2190-9. PMID: 23743821
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants.
Lundell M, Mattsson A, Karlsson P, Holmberg E, Gustafsson A, Holm LE
Radiat Res 1999 May;151(5):626-32. PMID: 10319736
Intracranial tumors after radium treatment for skin hemangioma during infancy--a cohort and case-control study.
Karlsson P, Holmberg E, Lundberg LM, Nordborg C, Wallgren A
Radiat Res 1997 Aug;148(2):161-7. PMID: 9254735
A spinal arteriovenous malformation with hereditary cutaneous hemangiomas.
Kaplan P, Hollenberg RD, Fraser FC
Am J Dis Child 1976 Dec;130(12):1329-31. doi: 10.1001/archpedi.1976.02120130035007. PMID: 998575

Therapy

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
The expression and function of miR-424 in infantile skin hemangioma and its mechanism.
Yang L, Dai J, Li F, Cheng H, Yan D, Ruan Q
Sci Rep 2017 Sep 19;7(1):11846. doi: 10.1038/s41598-017-10674-7. PMID: 28928430Free PMC Article
New dosimetry for childhood skin hemangioma treatments with (226)Ra needles or tubes.
Lundell M, Karlsson M, Carlsson Tedgren Å
Radiother Oncol 2015 Jul;116(1):139-42. Epub 2015 Jun 21 doi: 10.1016/j.radonc.2015.06.014. PMID: 26104976
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants.
Lundell M, Mattsson A, Karlsson P, Holmberg E, Gustafsson A, Holm LE
Radiat Res 1999 May;151(5):626-32. PMID: 10319736
Risk of solid tumors after irradiation in infancy.
Lundell M, Holm LE
Acta Oncol 1995;34(6):727-34. doi: 10.3109/02841869509127179. PMID: 7576738

Prognosis

Activation of Hedgehog Signaling in Aggressive Hepatic Hemangioma in Newborns and Infants.
Wendling-Keim D, Vokuhl C, Walz C, Rieder L, Grantzow R, VON Schweinitz D, Kappler R, Berger M
Anticancer Res 2019 May;39(5):2351-2360. doi: 10.21873/anticanres.13352. PMID: 31092427
Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Breast cancer following radiotherapy for a hemangioma during childhood.
Haddy N, Dondon MG, Paoletti C, Rubino C, Mousannif A, Shamsaldin A, Doyon F, Labbé M, Robert C, Avril MF, Demars R, Molinie F, Lefkopoulos D, Diallo I, de Vathaire F
Cancer Causes Control 2010 Nov;21(11):1807-16. Epub 2010 Jul 7 doi: 10.1007/s10552-010-9607-5. PMID: 20607383
Breast cancer risk after radiotherapy in infancy: a pooled analysis of two Swedish cohorts of 17,202 infants.
Lundell M, Mattsson A, Karlsson P, Holmberg E, Gustafsson A, Holm LE
Radiat Res 1999 May;151(5):626-32. PMID: 10319736
Risk of solid tumors after irradiation in infancy.
Lundell M, Holm LE
Acta Oncol 1995;34(6):727-34. doi: 10.3109/02841869509127179. PMID: 7576738

Clinical prediction guides

Radiation-induced genomic instability in breast carcinomas of the Swedish hemangioma cohort.
Biermann J, Langen B, Nemes S, Holmberg E, Parris TZ, Werner Rönnerman E, Engqvist H, Kovács A, Helou K, Karlsson P
Genes Chromosomes Cancer 2019 Sep;58(9):627-635. Epub 2019 Apr 12 doi: 10.1002/gcc.22757. PMID: 30938900
Retrospective cohort study and biobanking of patients treated for hemangioma in childhood - telomeres as biomarker of aging and radiation exposure.
Frenzel M, Ricoul M, Benadjaoud MA, Bellamy M, Lenain A, Haddy N, Diallo I, Mateus C, de Vathaire F, Sabatier L
Int J Radiat Biol 2017 Oct;93(10):1040-1053. Epub 2017 Jun 26 doi: 10.1080/09553002.2017.1337278. PMID: 28649877
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma.
Haddy N, Mousannif A, Paoletti C, Dondon MG, Shamsaldin A, Doyon F, Avril MF, Fragu P, Labbé M, Lefkopoulos D, Chavaudra J, Robert C, Diallo I, de Vathaire F
Melanoma Res 2012 Feb;22(1):77-85. doi: 10.1097/CMR.0b013e32834dcff1. PMID: 22082956
Mortality from leukemia after irradiation in infancy for skin hemangioma.
Lundell M, Holm LE
Radiat Res 1996 May;145(5):595-601. PMID: 8619025
Risk of solid tumors after irradiation in infancy.
Lundell M, Holm LE
Acta Oncol 1995;34(6):727-34. doi: 10.3109/02841869509127179. PMID: 7576738

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