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Diastolic dysfunction

MedGen UID:
105464
•Concept ID:
C0520863
•
Pathologic Function
Synonym: Diastolic Dysfunction
SNOMED CT: Diastolic dysfunction (3545003)

Definition

Impairment in the filling of the ventricles during diastole. Causes include hypertrophic and restrictive cardiomyopathies, coronary artery disease, chronic high blood pressure, aortic stenosis, and aging. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Diastolic dysfunction

Professional guidelines

PubMed

2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, Dearani JA, Epps KC, Evanovich L, Ferrari VA, Joglar JA, Khan SS, Kim JJ, Kittleson MM, Krittanawong C, Martinez MW, Mital S, Naidu SS, Saberi S, Semsarian C, Times S, Waldman CB; Peer Review Committee Members
Circulation 2024 Jun 4;149(23):e1239-e1311. Epub 2024 May 8 doi: 10.1161/CIR.0000000000001250. PMID: 38718139
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e558-e631. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000937. PMID: 33215931

Recent clinical studies

Etiology

Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions.
van Ommen AMLN, Canto ED, Cramer MJ, Rutten FH, Onland-Moret NC, Ruijter HMD
BMC Med 2022 Dec 27;20(1):496. doi: 10.1186/s12916-022-02650-4. PMID: 36575484Free PMC Article
Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: A translational review of current literature.
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Diastolic Dysfunction, an Underestimated New Challenge in Dialysis.
Escoli R, Carvalho MJ, Cabrita A, Rodrigues A
Ther Apher Dial 2019 Apr;23(2):108-117. Epub 2018 Sep 25 doi: 10.1111/1744-9987.12756. PMID: 30255628
Cirrhotic cardiomyopathy.
Ruiz-del-Árbol L, Serradilla R
World J Gastroenterol 2015 Nov 7;21(41):11502-21. doi: 10.3748/wjg.v21.i41.11502. PMID: 26556983Free PMC Article
Pre-clinical diastolic dysfunction.
Wan SH, Vogel MW, Chen HH
J Am Coll Cardiol 2014 Feb 11;63(5):407-16. Epub 2013 Nov 27 doi: 10.1016/j.jacc.2013.10.063. PMID: 24291270Free PMC Article

Diagnosis

Septic cardiomyopathy: A narrative review.
Lima MR, Silva D
Rev Port Cardiol 2023 May;42(5):471-481. Epub 2023 Mar 7 doi: 10.1016/j.repc.2021.05.020. PMID: 36893835
Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: A translational review of current literature.
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure.
Mitter SS, Shah SJ, Thomas JD
J Am Coll Cardiol 2017 Mar 21;69(11):1451-1464. doi: 10.1016/j.jacc.2016.12.037. PMID: 28302294
Diastolic dysfunction.
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article

Therapy

Treatment of Cardiorenal Syndrome.
Rubinstein J, Sanford D
Cardiol Clin 2019 Aug;37(3):267-273. Epub 2019 May 15 doi: 10.1016/j.ccl.2019.04.002. PMID: 31279420
Hypertrophic cardiomyopathy.
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Diastolic dysfunction.
Jeong EM, Dudley SC Jr
Circ J 2015;79(3):470-7. Epub 2015 Feb 5 doi: 10.1253/circj.CJ-15-0064. PMID: 25746522Free PMC Article
New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment.
Zile MR, Brutsaert DL
Circulation 2002 Mar 26;105(12):1503-8. doi: 10.1161/hc1202.105290. PMID: 11914262
Transoesophageal stress echocardiography.
Flachskampf FA, Lethen H, Hoffmann R, Hanrath P
Eur Heart J 1997 Jun;18 Suppl D:D37-42. doi: 10.1093/eurheartj/18.suppl_d.37. PMID: 9183609

Prognosis

Epidemiology and pathogenesis of heart failure with preserved ejection fraction.
Nair N
Rev Cardiovasc Med 2020 Dec 30;21(4):531-540. doi: 10.31083/j.rcm.2020.04.154. PMID: 33387998
Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: A translational review of current literature.
Reichart D, Magnussen C, Zeller T, Blankenberg S
J Intern Med 2019 Oct;286(4):362-372. Epub 2019 Jul 29 doi: 10.1111/joim.12944. PMID: 31132311
Pediatric cardiac transplantation.
Ryan TD, Chin C
Semin Pediatr Surg 2017 Aug;26(4):206-212. Epub 2017 Jul 26 doi: 10.1053/j.sempedsurg.2017.07.012. PMID: 28964475
Diagnosis of heart failure with preserved ejection fraction.
Wachter R, Edelmann F
Heart Fail Clin 2014 Jul;10(3):399-406. doi: 10.1016/j.hfc.2014.04.010. PMID: 24975904
Restrictive cardiomyopathy.
Zangwill S, Hamilton R
Pacing Clin Electrophysiol 2009 Jul;32 Suppl 2:S41-3. doi: 10.1111/j.1540-8159.2009.02383.x. PMID: 19602161

Clinical prediction guides

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P
Circulation 2020 Dec 22;142(25):e533-e557. Epub 2020 Nov 20 doi: 10.1161/CIR.0000000000000938. PMID: 33215938
Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: Understanding Mechanisms by Using Noninvasive Methods.
Obokata M, Reddy YNV, Borlaug BA
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):245-257. Epub 2019 Jun 12 doi: 10.1016/j.jcmg.2018.12.034. PMID: 31202759Free PMC Article
Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography.
Nagueh SF
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):228-244. Epub 2019 Apr 12 doi: 10.1016/j.jcmg.2018.10.038. PMID: 30982669
Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Muchtar E, Blauwet LA, Gertz MA
Circ Res 2017 Sep 15;121(7):819-837. doi: 10.1161/CIRCRESAHA.117.310982. PMID: 28912185
Valsalva maneuver in echocardiography.
Ghazal SN
J Echocardiogr 2017 Mar;15(1):1-5. Epub 2016 Aug 11 doi: 10.1007/s12574-016-0310-8. PMID: 27515556

Recent systematic reviews

Epidemiology of heart failure in diabetes: a disease in disguise.
Hoek AG, Dal Canto E, Wenker E, Bindraban N, Handoko ML, Elders PJM, Beulens JWJ
Diabetologia 2024 Apr;67(4):574-601. Epub 2024 Feb 9 doi: 10.1007/s00125-023-06068-2. PMID: 38334818Free PMC Article
Beta-blocker therapy in heart failure with preserved ejection fraction (B-HFpEF): A systematic review and meta-analysis.
Kaddoura R, Madurasinghe V, Chapra A, Abushanab D, Al-Badriyeh D, Patel A
Curr Probl Cardiol 2024 Mar;49(3):102376. Epub 2024 Jan 5 doi: 10.1016/j.cpcardiol.2024.102376. PMID: 38184132
Efficacy and safety of cardiac resynchronization therapy in chemotherapy-induced cardiomyopathy: A systematic review.
Shehram M, Khalid H, Shafique HM, Umer B, Zafar A, Ullah A, Zaidi SMJ, Basit J, Mehmoodi A, Malik J
Ann Noninvasive Electrocardiol 2023 Sep;28(5):e13070. Epub 2023 Jul 12 doi: 10.1111/anec.13070. PMID: 37435629Free PMC Article
Diagnosis and Prevalence of Cirrhotic Cardiomyopathy: A Systematic Review and Meta-analysis.
Shahvaran SA, Menyhárt O, Csedrik L, Patai ÁV
Curr Probl Cardiol 2021 Oct;46(10):100821. Epub 2021 Feb 24 doi: 10.1016/j.cpcardiol.2021.100821. PMID: 34016482
Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review.
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH
Eur J Heart Fail 2016 Mar;18(3):242-52. Epub 2016 Jan 4 doi: 10.1002/ejhf.483. PMID: 26727047

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