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Dysmorphic features

MedGen UID:
473141
Concept ID:
C0432072
Congenital Abnormality
SNOMED CT: Dysmorphic features (253978002)

Professional guidelines

PubMed

Hokken-Koelega ACS, van der Steen M, Boguszewski MCS, Cianfarani S, Dahlgren J, Horikawa R, Mericq V, Rapaport R, Alherbish A, Braslavsky D, Charmandari E, Chernausek SD, Cutfield WS, Dauber A, Deeb A, Goedegebuure WJ, Hofman PL, Isganatis E, Jorge AA, Kanaka-Gantenbein C, Kashimada K, Khadilkar V, Luo XP, Mathai S, Nakano Y, Yau M
Endocr Rev 2023 May 8;44(3):539-565. doi: 10.1210/endrev/bnad002. PMID: 36635911Free PMC Article
Vasko A, Drivas TG, Schrier Vergano SA
Genes (Basel) 2021 Jun 19;12(6) doi: 10.3390/genes12060937. PMID: 34205270Free PMC Article
Adam MP, Banka S, Bjornsson HT, Bodamer O, Chudley AE, Harris J, Kawame H, Lanpher BC, Lindsley AW, Merla G, Miyake N, Okamoto N, Stumpel CT, Niikawa N; Kabuki Syndrome Medical Advisory Board
J Med Genet 2019 Feb;56(2):89-95. Epub 2018 Dec 4 doi: 10.1136/jmedgenet-2018-105625. PMID: 30514738

Recent clinical studies

Etiology

Carvalho LML, Jorge AAL, Bertola DR, Krepischi ACV, Rosenberg C
Curr Obes Rep 2024 Jun;13(2):313-337. Epub 2024 Jan 26 doi: 10.1007/s13679-023-00543-y. PMID: 38277088
Gallagher PG
Blood 2022 Aug 11;140(6):571-593. doi: 10.1182/blood.2020006479. PMID: 35213686Free PMC Article
Adam MP, Banka S, Bjornsson HT, Bodamer O, Chudley AE, Harris J, Kawame H, Lanpher BC, Lindsley AW, Merla G, Miyake N, Okamoto N, Stumpel CT, Niikawa N; Kabuki Syndrome Medical Advisory Board
J Med Genet 2019 Feb;56(2):89-95. Epub 2018 Dec 4 doi: 10.1136/jmedgenet-2018-105625. PMID: 30514738
Savage SA, Walsh MF
Hematol Oncol Clin North Am 2018 Aug;32(4):657-668. doi: 10.1016/j.hoc.2018.04.002. PMID: 30047418Free PMC Article
Cox DM, Butler MG
Int J Mol Sci 2015 Feb 13;16(2):4068-82. doi: 10.3390/ijms16024068. PMID: 25689425Free PMC Article

Diagnosis

Bourgois A, Bizaoui V, Colson C, Vincent-Devulder A, Molin A, Gérard M, Gruchy N
Am J Med Genet A 2024 Mar;194(3):e63457. Epub 2023 Oct 26 doi: 10.1002/ajmg.a.63457. PMID: 37881147
Condit PE, Meinen RD, Harer MW
Neoreviews 2022 Mar 1;23(3):e205-e207. doi: 10.1542/neo.23-3-e205. PMID: 35229132
Kruszka P, Tekendo-Ngongang C, Muenke M
Curr Opin Pediatr 2019 Dec;31(6):702-707. doi: 10.1097/MOP.0000000000000816. PMID: 31693576
Cheetham T, Davies JH
Arch Dis Child 2014 Aug;99(8):767-71. Epub 2014 Mar 5 doi: 10.1136/archdischild-2013-304829. PMID: 24599067
Kraoua L, Capri Y, Perrin L, Benmansour A, Verloes A
Am J Med Genet A 2012 Sep;158A(9):2233-8. Epub 2012 Jul 18 doi: 10.1002/ajmg.a.35212. PMID: 22811276

Therapy

Hokken-Koelega ACS, van der Steen M, Boguszewski MCS, Cianfarani S, Dahlgren J, Horikawa R, Mericq V, Rapaport R, Alherbish A, Braslavsky D, Charmandari E, Chernausek SD, Cutfield WS, Dauber A, Deeb A, Goedegebuure WJ, Hofman PL, Isganatis E, Jorge AA, Kanaka-Gantenbein C, Kashimada K, Khadilkar V, Luo XP, Mathai S, Nakano Y, Yau M
Endocr Rev 2023 May 8;44(3):539-565. doi: 10.1210/endrev/bnad002. PMID: 36635911Free PMC Article
Mutlu-Albayrak H, Bulut C, Çaksen H
Pediatr Neonatol 2017 Apr;58(2):158-164. Epub 2016 Jun 17 doi: 10.1016/j.pedneo.2016.01.009. PMID: 27422007
van Wijk RM, van Vlimmeren LA, Groothuis-Oudshoorn CG, Van der Ploeg CP, Ijzerman MJ, Boere-Boonekamp MM
BMJ 2014 May 1;348:g2741. doi: 10.1136/bmj.g2741. PMID: 24784879Free PMC Article
Jefferies JL, Kim JJ, Belmont JW, Friedman RA
Tex Heart Inst J 2009;36(4):349-51. PMID: 19693314Free PMC Article
Turnbull C, Mirugaesu N, Eeles R
Clin Oncol (R Coll Radiol) 2006 Apr;18(3):257-67. doi: 10.1016/j.clon.2005.11.013. PMID: 16605057

Prognosis

Carvalho LML, Jorge AAL, Bertola DR, Krepischi ACV, Rosenberg C
Curr Obes Rep 2024 Jun;13(2):313-337. Epub 2024 Jan 26 doi: 10.1007/s13679-023-00543-y. PMID: 38277088
Bourgois A, Bizaoui V, Colson C, Vincent-Devulder A, Molin A, Gérard M, Gruchy N
Am J Med Genet A 2024 Mar;194(3):e63457. Epub 2023 Oct 26 doi: 10.1002/ajmg.a.63457. PMID: 37881147
Dorum S, Gorukmez O
Am J Med Genet A 2021 Oct;185(10):2873-2877. Epub 2021 May 26 doi: 10.1002/ajmg.a.62354. PMID: 34037310
Yates TM, Drucker M, Barnicoat A, Low K, Gerkes EH, Fry AE, Parker MJ, O'Driscoll M, Charles P, Cox H, Marey I, Keren B, Rinne T, McEntagart M, Ramachandran V, Drury S, Vansenne F, Sival DA, Herkert JC, Callewaert B, Tan WH, Balasubramanian M
Hum Mutat 2020 May;41(5):1042-1050. Epub 2020 Mar 5 doi: 10.1002/humu.24001. PMID: 32097528
Riley KN, Catalano LM, Bernat JA, Adams SD, Martin DM, Lalani SR, Patel A, Burnside RD, Innis JW, Rudd MK
Am J Med Genet A 2015 Nov;167A(11):2664-73. Epub 2015 Jul 31 doi: 10.1002/ajmg.a.37269. PMID: 26227573

Clinical prediction guides

Pan X, Tao AM, Lu S, Ma M, Hannan SB, Slaugh R, Drewes Williams S, O'Grady L, Kanca O, Person R, Carter MT, Platzer K, Schnabel F, Abou Jamra R, Roberts AE, Newburger JW, Revah-Politi A, Granadillo JL, Stegmann APA, Sinnema M, Accogli A, Salpietro V, Capra V, Ghaloul-Gonzalez L, Brueckner M, Simon MEH, Sweetser DA, Glinton KE, Kirk SE; Baylor College of Medicine Center for Precision Medicine Models, Wangler MF, Yamamoto S, Chung WK, Bellen HJ
Am J Hum Genet 2024 Apr 4;111(4):742-760. Epub 2024 Mar 12 doi: 10.1016/j.ajhg.2024.02.007. PMID: 38479391Free PMC Article
Bourgois A, Bizaoui V, Colson C, Vincent-Devulder A, Molin A, Gérard M, Gruchy N
Am J Med Genet A 2024 Mar;194(3):e63457. Epub 2023 Oct 26 doi: 10.1002/ajmg.a.63457. PMID: 37881147
Riley KN, Catalano LM, Bernat JA, Adams SD, Martin DM, Lalani SR, Patel A, Burnside RD, Innis JW, Rudd MK
Am J Med Genet A 2015 Nov;167A(11):2664-73. Epub 2015 Jul 31 doi: 10.1002/ajmg.a.37269. PMID: 26227573
Cox DM, Butler MG
Int J Mol Sci 2015 Feb 13;16(2):4068-82. doi: 10.3390/ijms16024068. PMID: 25689425Free PMC Article
van Wijk RM, van Vlimmeren LA, Groothuis-Oudshoorn CG, Van der Ploeg CP, Ijzerman MJ, Boere-Boonekamp MM
BMJ 2014 May 1;348:g2741. doi: 10.1136/bmj.g2741. PMID: 24784879Free PMC Article

Recent systematic reviews

Akison LK, Hayes N, Vanderpeet C, Logan J, Munn Z, Middleton P, Moritz KM, Reid N; Australian FASD Guidelines Development Group, on behalf of the Australian FASD Guidelines Consortium
BMC Med 2024 Oct 15;22(1):467. doi: 10.1186/s12916-024-03656-w. PMID: 39407296Free PMC Article
Martín-Martín M, Cortés-Martín J, Tovar-Gálvez MI, Sánchez-García JC, Díaz-Rodríguez L, Rodríguez-Blanque R
Int J Environ Res Public Health 2022 Feb 7;19(3) doi: 10.3390/ijerph19031870. PMID: 35162892Free PMC Article
Dietrich J, Lovell S, Veatch OJ, Butler MG
Am J Med Genet A 2022 Feb;188(2):579-589. Epub 2021 Nov 13 doi: 10.1002/ajmg.a.62557. PMID: 34773373
Jacobs EZ, Brown K, Byler MC, D'haenens E, Dheedene A, Henderson LB, Humberson JB, van Jaarsveld RH, Kanani F, Lebel RR, Millan F, Oegema R, Oostra A, Parker MJ, Rhodes L, Saenz M, Seaver LH, Si Y, Vanlander A, Vergult S, Callewaert B
Clin Genet 2021 Feb;99(2):259-268. Epub 2020 Nov 23 doi: 10.1111/cge.13874. PMID: 33131045
Kaur Y, de Souza RJ, Gibson WT, Meyre D
Obes Rev 2017 Jun;18(6):603-634. Epub 2017 Mar 27 doi: 10.1111/obr.12531. PMID: 28346723

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