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Idiopathic growth hormone deficiency(IGHD)

MedGen UID:
450529
•Concept ID:
C0342381
•
Disease or Syndrome
Synonym: IGHD
SNOMED CT: Idiopathic growth hormone insufficiency (237688008); IGHD - Idiopathic growth hormone deficiency (237688008); Idiopathic growth hormone deficiency (237688008)
 
Related genes: GH1, BTK

Professional guidelines

PubMed

Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Recent clinical studies

Etiology

Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Near final height in patients with idiopathic growth hormone deficiency: A single-centre experience.
Kurnaz E, Çetinkaya S, Aycan Z
J Paediatr Child Health 2018 Nov;54(11):1221-1226. Epub 2018 May 28 doi: 10.1111/jpc.14061. PMID: 29806866
Final height in growth-hormone-treated children with idiopathic growth hormone deficiency: the Malaysian experience.
Ooi HL, Wu LL
Med J Malaysia 2011 Dec;66(5):479-83. PMID: 22390105
Idiopathic growth hormone deficiency in the morphologically normal pituitary gland is associated with perfusion delay.
Wang CY, Chung HW, Cho NY, Liu HS, Chou MC, Kao HW, Juan CJ, Lee MS, Huang GS, Chen CY
Radiology 2011 Jan;258(1):213-21. Epub 2010 Sep 30 doi: 10.1148/radiol.10100504. PMID: 20884913

Diagnosis

Growth hormone treatment in children with short stature: impact of the diagnosis on parents.
Witt S, Bloemeke J, Bullinger M, Dörr HG, Silva N, Quitmann JH
J Pediatr Endocrinol Metab 2024 Apr 25;37(4):326-335. Epub 2024 Mar 1 doi: 10.1515/jpem-2023-0420. PMID: 38421314
The landscape of retesting in childhood-onset idiopathic growth hormone deficiency and its reversibility: a systematic review and meta-analysis.
Laurer E, Sirovina A, Blaschitz A, Tischlinger K, Montero-Lopez R, Hörtenhuber T, Wimleitner M, Högler W
Eur J Endocrinol 2022 Aug 1;187(2):265-278. Epub 2022 Jun 29 doi: 10.1530/EJE-21-1179. PMID: 35670597
Psychiatric Disorders and Peer-Victimization in Children and Adolescents With Growth Hormone Deficiency.
Gizli Çoban Ö, Bedel A, Önder A, Sürer Adanır A, Tuhan H, Parlak M
Clin Pediatr (Phila) 2022 Oct;61(10):684-691. Epub 2022 May 17 doi: 10.1177/00099228221096654. PMID: 35581721
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone.
Burns EC, Tanner JM, Preece MA, Cameron N
Eur J Pediatr 1981 Oct;137(2):155-64. doi: 10.1007/BF00441309. PMID: 7308226

Therapy

Complex relationship between growth hormone and sleep in children: insights, discrepancies, and implications.
Zaffanello M, Pietrobelli A, Cavarzere P, Guzzo A, Antoniazzi F
Front Endocrinol (Lausanne) 2023;14:1332114. Epub 2024 Jan 24 doi: 10.3389/fendo.2023.1332114. PMID: 38327902Free PMC Article
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Final height in growth-hormone-treated children with idiopathic growth hormone deficiency: the Malaysian experience.
Ooi HL, Wu LL
Med J Malaysia 2011 Dec;66(5):479-83. PMID: 22390105
Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone.
Burns EC, Tanner JM, Preece MA, Cameron N
Eur J Pediatr 1981 Oct;137(2):155-64. doi: 10.1007/BF00441309. PMID: 7308226

Prognosis

Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency, Turner syndrome, short stature, born small for gestational age and idiopathic short stature: KIGS analysis and review.
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173
Prediction model of total pubertal growth in idiopathic growth hormone deficiency: analysis of data from KIGS.
Ranke MB, Martin DD, Lindberg A
Horm Res 2003;60(Suppl 1):58-9. doi: 10.1159/000071227. PMID: 12955019

Clinical prediction guides

The landscape of retesting in childhood-onset idiopathic growth hormone deficiency and its reversibility: a systematic review and meta-analysis.
Laurer E, Sirovina A, Blaschitz A, Tischlinger K, Montero-Lopez R, Hörtenhuber T, Wimleitner M, Högler W
Eur J Endocrinol 2022 Aug 1;187(2):265-278. Epub 2022 Jun 29 doi: 10.1530/EJE-21-1179. PMID: 35670597
Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Prediction model of total pubertal growth in idiopathic growth hormone deficiency: analysis of data from KIGS.
Ranke MB, Martin DD, Lindberg A
Horm Res 2003;60(Suppl 1):58-9. doi: 10.1159/000071227. PMID: 12955019

Recent systematic reviews

Complex relationship between growth hormone and sleep in children: insights, discrepancies, and implications.
Zaffanello M, Pietrobelli A, Cavarzere P, Guzzo A, Antoniazzi F
Front Endocrinol (Lausanne) 2023;14:1332114. Epub 2024 Jan 24 doi: 10.3389/fendo.2023.1332114. PMID: 38327902Free PMC Article
The landscape of retesting in childhood-onset idiopathic growth hormone deficiency and its reversibility: a systematic review and meta-analysis.
Laurer E, Sirovina A, Blaschitz A, Tischlinger K, Montero-Lopez R, Hörtenhuber T, Wimleitner M, Högler W
Eur J Endocrinol 2022 Aug 1;187(2):265-278. Epub 2022 Jun 29 doi: 10.1530/EJE-21-1179. PMID: 35670597

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