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Granular cell cancer

MedGen UID:
87276
•Concept ID:
C0334618
•
Neoplastic Process
Synonym: malignant granular cell tumor
SNOMED CT: Malignant granular cell tumor (13238004); Malignant granular cell myoblastoma (13238004); Malignant granular cell tumor (404041003); Granular cell tumor, malignant (13238004); Granular cell myoblastoma, malignant (13238004)
 
Monarch Initiative: MONDO:0003252

Definition

An uncommon granular cell tumor which may metastasize to other anatomic sites. Morphologic characteristics include the presence of spindling neoplastic cells, necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic activity. [from NCI]

Professional guidelines

PubMed

Large Granular Lymphocytic Leukemia: Current State of Diagnosis, Pathogenesis and Treatment.
Magnano L, Rivero A, Matutes E
Curr Oncol Rep 2022 May;24(5):633-644. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01159-y. PMID: 35212923
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Etiology

Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Front Endocrinol (Lausanne) 2022;13:962154. Epub 2022 Nov 9 doi: 10.3389/fendo.2022.962154. PMID: 36465612Free PMC Article
Large Granular Lymphocytic Leukemia: Current State of Diagnosis, Pathogenesis and Treatment.
Magnano L, Rivero A, Matutes E
Curr Oncol Rep 2022 May;24(5):633-644. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01159-y. PMID: 35212923
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Benign esophageal tumors.
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126

Diagnosis

Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features.
Salah HT, D'ardis JA, Baek D, Schwartz MR, Ayala AG, Ro JY
Ann Diagn Pathol 2022 Jun;58:151937. Epub 2022 Mar 24 doi: 10.1016/j.anndiagpath.2022.151937. PMID: 35344860
T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics.
Shi M, Olteanu H, Jevremovic D, He R, Viswanatha D, Corley H, Horna P
Mod Pathol 2020 Oct;33(10):2046-2057. Epub 2020 May 13 doi: 10.1038/s41379-020-0568-2. PMID: 32404954
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Flow cytometry in hematological nonmalignant disorders.
Béné MC, Le Bris Y, Robillard N, Wuillème S, Fouassier M, Eveillard M
Int J Lab Hematol 2016 Feb;38(1):5-16. Epub 2015 Nov 6 doi: 10.1111/ijlh.12438. PMID: 26542092

Therapy

Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Front Endocrinol (Lausanne) 2022;13:962154. Epub 2022 Nov 9 doi: 10.3389/fendo.2022.962154. PMID: 36465612Free PMC Article
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
Large granular lymphocytosis during quizartinib therapy.
Bertoli S, Rieu JB, Récher C, Vergez F
Br J Haematol 2020 Apr;189(1):7. Epub 2020 Mar 12 doi: 10.1111/bjh.16373. PMID: 32162314
Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation.
Awada H, Mahfouz RZ, Durrani J, Kishtagari A, Jagadeesh D, Lichtin AE, Hill BT, Hamilton BK, Carraway HE, Nazha A, Majhail NS, Sobecks R, Visconte V, Kalaycio M, Sekeres MA, Maciejewski JP
Br J Haematol 2020 Apr;189(2):318-322. Epub 2020 Jan 20 doi: 10.1111/bjh.16336. PMID: 31958160Free PMC Article
Retroviral sero-reactivity in LGL leukaemia patients and family members.
Nyland SB, Feith DJ, Poss M, Olson TL, Krissinger DJ, Poiesz BJ, Ruscetti FW, Loughran TP Jr
Br J Haematol 2020 Feb;188(4):522-527. Epub 2019 Oct 14 doi: 10.1111/bjh.16223. PMID: 31608437Free PMC Article

Prognosis

A modern view of LGL leukemia.
Marchand T, Lamy T, Loughran TP Jr
Blood 2024 Oct 31;144(18):1910-1923. doi: 10.1182/blood.2023021790. PMID: 38848524
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Pancreatic panniculitis.
Rongioletti F, Caputo V
G Ital Dermatol Venereol 2013 Aug;148(4):419-25. PMID: 23900163
Bronchial oncocytoma.
de Aquino RT, Magliari ME, Saad R Jr, Neto VD, Filho JE, Neto CD, Capelozzi VL
Sao Paulo Med J 2000 Nov 9;118(6):195-7. doi: 10.1590/s1516-31802000000600009. PMID: 11120552Free PMC Article
Clonal diseases of large granular lymphocytes.
Loughran TP Jr
Blood 1993 Jul 1;82(1):1-14. PMID: 8324214

Clinical prediction guides

Pancreatic neuroendocrine tumor with abundant mitochondria.
Shetty D, Raj A, Amarapurkar A
Indian J Cancer 2024 Apr 1;61(2):415-417. Epub 2024 Jul 16 doi: 10.4103/ijc.ijc_679_21. PMID: 39016266
A modern view of LGL leukemia.
Marchand T, Lamy T, Loughran TP Jr
Blood 2024 Oct 31;144(18):1910-1923. doi: 10.1182/blood.2023021790. PMID: 38848524
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
The nucleolus.
Schwarzacher HG, Wachtler F
Anat Embryol (Berl) 1993 Dec;188(6):515-36. doi: 10.1007/BF00187008. PMID: 8129175
Granular cell myoblastoma.
Chrestian MA, Gambarelli D, Hassoun J, Gola R, Toga M, Bonerandi JJ
J Cutan Pathol 1977;4(2):80-9. doi: 10.1111/j.1600-0560.1977.tb00892.x. PMID: 199624

Recent systematic reviews

A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case.
Severino Lazo RJG, Martins-de-Barros AV, da Silva Cunha J, de Paiva Macedo RA, Borges MA, Islam MN, Vasconcelos BCDE, Carvalho MV
Head Neck Pathol 2023 Sep;17(3):793-802. Epub 2023 Apr 28 doi: 10.1007/s12105-023-01553-x. PMID: 37118351Free PMC Article
Intra-cerebellar schwannoma with various degenerative changes: a case report and a systematic review.
Takeuchi Y, Arakawa Y, Yokoo H, Mikami Y, Terada Y, Yoshida K, Miyamoto S, Haga H
BMC Neurol 2022 Feb 24;22(1):66. doi: 10.1186/s12883-022-02596-3. PMID: 35209854Free PMC Article
Oral granular cell tumour: A multicentric study of 56 cases and a systematic review.
Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368
Granular cell ameloblastoma: A rare case report and review of literature.
Kulkarni D, Ingale Y, Ingale M, Ajabrao BN, Mayank M, Kulkarni A
Indian J Dent Res 2018 Nov-Dec;29(6):830-835. doi: 10.4103/ijdr.IJDR_407_17. PMID: 30589015
Granular cell tumor of the infundibulum: a systematic review of MR-radiography, pathology, and clinical findings.
Polasek JB, Laviv Y, Nigim F, Rojas R, Anderson M, Varma H, Kasper EM
J Neurooncol 2018 Nov;140(2):181-198. Epub 2018 Aug 23 doi: 10.1007/s11060-018-2986-2. PMID: 30141059

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