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Esophageal carcinoma

MedGen UID:
56256
Concept ID:
C0152018
Neoplastic Process
Synonyms: Carcinoma of esophagus; Oesophageal carcinoma
SNOMED CT: Carcinoma of esophagus (372138000)
 
HPO: HP:0011459
Monarch Initiative: MONDO:0019086
OMIM®: 133239
Orphanet: ORPHA70482

Definition

The presence of a carcinoma of the esophagus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal carcinoma
Follow this link to review classifications for Esophageal carcinoma in Orphanet.

Conditions with this feature

Barrett esophagus
MedGen UID:
2551
Concept ID:
C0004763
Disease or Syndrome
Barrett esophagus, or Barrett metaplasia, describes the phenotypic change of normal esophageal squamous epithelium to a columnar and intestinal-type epithelium. This metaplastic change is important because patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett metaplasia is gastroesophageal reflux (GER; 109350). The retrograde movement of acid and bile salts from the stomach into the esophagus in this disease causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes (summary by Wong et al., 2005).
Malignant tumor of esophagus
MedGen UID:
107792
Concept ID:
C0546837
Neoplastic Process
Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is one of the most common cancers worldwide. Both environmental and genetic risk factors play a role in the pathogenesis of the disorder. In Europe and North America, heavy smoking, alcohol consumption, and increased body mass index (BMI) are the main environmental risk factors. In contrast, the particularly high incidence of ESCC in some areas of China, central Asia, and southern Africa is associated with nutritional deficiencies, high intake of nitrosamine-rich or pickled vegetables, and low socioeconomic status; smoking, alcohol consumption, and BMI play a lesser role in these populations. There is a tendency for familial aggregation of ESCC in high-risk geographic areas, suggesting a genetic component to increased susceptibility. Gastric cardia adenocarcinoma is another common type of cancer in China that shows similarities to ESCC in terms of geographic distribution and environmental risk factors (summary by Wang et al., 2010 and Abnet et al., 2010). Genetic Heterogeneity of Susceptibility to Esophageal Cancer See a variant in the ADH1B gene (103720.0001) for discussion of a possible genetic association with protection against squamous cell aerodigestive tract cancer, including esophageal cancer, in alcohol drinkers. See a variant in the ALDH2 gene (100650.0001) for discussion of a possible genetic association with increased risk for esophageal cancer in alcohol drinkers due to interaction between variants in the ADH1B and ALDH2 genes. See the S100A14 gene (607986) on chromosome 1q21 for a discussion of a possible association between variation in that gene and susceptibility to esophageal squamous cell carcinoma among smokers. Genetic Heterogeneity of Somatic Mutations in Esophageal Cancer Somatic mutations in several different genes have been found in esophageal cancer tissue. These genes include TP53 (191170), CDKN2A (600160), DEC1 (604767), DCC (120470), DLEC1 (604050), TGFBR2 (190182), LZTS1 (606551), RNF6 (604242), WWOX (605131), APC (611731), and RUNX3 (600210).
Palmoplantar keratoderma-esophageal carcinoma syndrome
MedGen UID:
324338
Concept ID:
C1835664
Neoplastic Process
Tylosis with esophageal cancer (TOC) is an autosomal dominant syndrome characterized by palmoplantar keratoderma (PPK; see 600962 and 144200), oral precursor lesions, and a high lifetime risk of esophageal cancer (summary by Blaydon et al., 2012).

Professional guidelines

PubMed

Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article
Brücher BL, Kitajima M, Siewert JR
Cancer Invest 2014 Dec;32(10):497-506. Epub 2014 Sep 24 doi: 10.3109/07357907.2014.958497. PMID: 25250506Free PMC Article
Wang KK, Wongkeesong M, Buttar NS
Gastroenterology 2005 May;128(5):1471-505. doi: 10.1053/j.gastro.2005.03.077. PMID: 15887129

Recent clinical studies

Etiology

Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Li K, Mao J, Huang Y
Int J Surg 2024 Mar 1;110(3):1882-1883. doi: 10.1097/JS9.0000000000001020. PMID: 38116684Free PMC Article
Sugawara K, Oka D, Hara H, Yoshii T, Ushijima H, Kudo S, Fukuda T
BMC Cancer 2023 Nov 1;23(1):1051. doi: 10.1186/s12885-023-11568-w. PMID: 37915027Free PMC Article
Urabe M, Ueno M, Yago A, Shimoyama H, Ohkura Y, Haruta S, Udagawa H
Ann Thorac Cardiovasc Surg 2022 Oct 20;28(5):366-370. Epub 2021 Apr 27 doi: 10.5761/atcs.cr.20-00361. PMID: 33907054Free PMC Article
Ido K, Yamamoto H, Kawamoto C, Koiwai H, Yoshida Y, Kimura K
Gastrointest Endosc 1997 May;45(5):420-3. doi: 10.1016/s0016-5107(97)70156-1. PMID: 9165327

Diagnosis

Jiang M, Chen P, Zhao G, Zheng J
Ann Thorac Surg 2022 Feb;113(2):e155. Epub 2021 Oct 22 doi: 10.1016/j.athoracsur.2021.09.042. PMID: 34695406
Mackelaite L, Lederer E
Am J Med Sci 2018 Dec;356(6):567-569. Epub 2018 Jun 6 doi: 10.1016/j.amjms.2018.05.014. PMID: 30166051
Zwischenberger JB, Sankar AB
Chest Surg Clin N Am 1995 Aug;5(3):527-42. PMID: 7583037
Bruckstein AH
Am Fam Physician 1989 Jan;39(1):147-56. PMID: 2643274
Kreutzer EW
Ear Nose Throat J 1984 Jan;63(1):48-51. PMID: 6365514

Therapy

Abushukair H, Abushukair A, Singh M, Saeed A
Surg Oncol Clin N Am 2024 Jul;33(3):583-593. Epub 2024 Jan 20 doi: 10.1016/j.soc.2023.12.024. PMID: 38789200
Rached L, Laparra A, Sakkal M, Danlos FX, Barlesi F, Carbonnel F, De Martin E, Ducreux M, Even C, Le Pavec J, Michot JM, M Ribeiro J, Scotte F, Ponce Aix S, Lambotte O, Baldini C, Champiat S
Cancer Treat Rev 2024 Jun;127:102751. Epub 2024 May 4 doi: 10.1016/j.ctrv.2024.102751. PMID: 38729086
Luo H, Lu J, Bai Y, Mao T, Wang J, Fan Q, Zhang Y, Zhao K, Chen Z, Gao S, Li J, Fu Z, Gu K, Liu Z, Wu L, Zhang X, Feng J, Niu Z, Ba Y, Zhang H, Liu Y, Zhang L, Min X, Huang J, Cheng Y, Wang D, Shen Y, Yang Q, Zou J, Xu RH; ESCORT-1st Investigators
JAMA 2021 Sep 14;326(10):916-925. doi: 10.1001/jama.2021.12836. PMID: 34519801Free PMC Article
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Brücher BL, Kitajima M, Siewert JR
Cancer Invest 2014 Dec;32(10):497-506. Epub 2014 Sep 24 doi: 10.3109/07357907.2014.958497. PMID: 25250506Free PMC Article

Prognosis

Li K, Mao J, Huang Y
Int J Surg 2024 Mar 1;110(3):1882-1883. doi: 10.1097/JS9.0000000000001020. PMID: 38116684Free PMC Article
Hulshof MCCM, Geijsen ED, Rozema T, Oppedijk V, Buijsen J, Neelis KJ, Nuyttens JJME, van der Sangen MJC, Jeene PM, Reinders JG, van Berge Henegouwen MI, Thano A, van Hooft JE, van Laarhoven HWM, van der Gaast A
J Clin Oncol 2021 Sep 1;39(25):2816-2824. Epub 2021 Jun 8 doi: 10.1200/JCO.20.03697. PMID: 34101496
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261
Lerut T, Coosemans W, De Leyn P, Van Raemdonck D, Deneffe G, Decker G
Chest 1999 Dec;116(6 Suppl):463S-465S. doi: 10.1378/chest.116.suppl_3.463s. PMID: 10619509
Caletti G, Fusaroli P, Villa-Gomez Roig G, De Groot KM, Nageshwar Reddy D
Gastrointest Endosc 1999 Jun;49(6):814-6; discussion 816-7. doi: 10.1016/s0016-5107(99)70321-4. PMID: 10343237

Clinical prediction guides

Xie L, Zhang Z
Front Immunol 2024;15:1334992. Epub 2024 Jan 16 doi: 10.3389/fimmu.2024.1334992. PMID: 38292873Free PMC Article
Sugawara K, Oka D, Hara H, Yoshii T, Ushijima H, Kudo S, Fukuda T
BMC Cancer 2023 Nov 1;23(1):1051. doi: 10.1186/s12885-023-11568-w. PMID: 37915027Free PMC Article
Coluccia M
Int J Mol Sci 2023 Aug 2;24(15) doi: 10.3390/ijms241512342. PMID: 37569718Free PMC Article
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent systematic reviews

Lee SL, Yadav P, Starekova J, Christensen L, Chandereng T, Chappell R, Reeder SB, Bassetti MF
Radiology 2021 Jun;299(3):583-594. Epub 2021 Mar 30 doi: 10.1148/radiol.2021202857. PMID: 33787334
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Chetwood JD, Garg P, Finch P, Gordon M
Expert Rev Gastroenterol Hepatol 2019 Jan;13(1):71-88. Epub 2018 Nov 14 doi: 10.1080/17474124.2019.1543024. PMID: 30791842
Tustumi F, Bernardo WM, da Rocha JRM, Szachnowicz S, Seguro FC, Bianchi ET, Sallum RAA, Cecconello I
Dis Esophagus 2017 Oct 1;30(10):1-8. doi: 10.1093/dote/dox072. PMID: 28859394
Chen H, Nie S, Zhu Y, Lu M
Sci Rep 2015 Oct 14;5:15203. doi: 10.1038/srep15203. PMID: 26462879Free PMC Article

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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