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Erythema infectiosum

MedGen UID:
43142
•Concept ID:
C0085273
•
Disease or Syndrome
Synonym: Human parvovirus B19 infection
SNOMED CT: Primate erythroparvovirus 1 infection (34730008); Parvovirus B19 infection (34730008); Slapped cheek syndrome (34730008); Erythema infectiosum (34730008); Fifth disease (34730008); Erythema contagiosum (34730008)
 
Monarch Initiative: MONDO:0006544

Definition

A self-limited viral infectious disorder caused by the human parvovirus B19. It affects predominantly children and is characterized by the development of a bright red skin eruption in the cheeks. It is followed by a maculopapular skin eruption in the extremities which eventually fades into a lacey pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythema infectiosum

Professional guidelines

PubMed

Identification and management of congenital parvovirus B19 infection.
Attwood LO, Holmes NE, Hui L
Prenat Diagn 2020 Dec;40(13):1722-1731. Epub 2020 Sep 30 doi: 10.1002/pd.5819. PMID: 32860469
Parvovirus B19 infection in pregnancy.
Crane J, Mundle W, Boucoiran I; MATERNAL FETAL MEDICINE COMMITTEE
J Obstet Gynaecol Can 2014 Dec;36(12):1107-1116. doi: 10.1016/S1701-2163(15)30390-X. PMID: 25668048
Parvovirus infection and its treatment.
Young NS
Clin Exp Immunol 1996 May;104 Suppl 1:26-30. PMID: 8625539

Recent clinical studies

Etiology

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024.
d'Humières C, Fouillet A, Verdurme L, Lakoussan SB, Gallien Y, Coignard C, Hervo M, Ebel A, Soares A, Visseaux B, Maire B, Juan PH, Parent du Châtelet I, Guthmann JP, Durand J
Euro Surveill 2024 Jun;29(25) doi: 10.2807/1560-7917.ES.2024.29.25.2400339. PMID: 38904112Free PMC Article
Hematologic Manifestations of Parvovirus B19 Infection.
Algwaiz G, Alharbi A, Alsehaim K, Alahmari A, El Fakih R, Aljurf M
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):316-322. doi: 10.56875/2589-0646.1031. PMID: 37363985
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Parvovirus B19 infections.
Sabella C, Goldfarb J
Am Fam Physician 1999 Oct 1;60(5):1455-60. PMID: 10524489
Erythema infectiosum and parvovirus B19 infection in pregnancy. Infectious Diseases and Immunization Committee, Canadian Paediatric Society.
CMAJ 1988 Oct 1;139(7):633-4. PMID: 2843273Free PMC Article

Diagnosis

Hematologic Manifestations of Parvovirus B19 Infection.
Algwaiz G, Alharbi A, Alsehaim K, Alahmari A, El Fakih R, Aljurf M
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):316-322. doi: 10.56875/2589-0646.1031. PMID: 37363985
Parvovirus b19 infection in pregnancy - A review.
Gigi CE, Anumba DOC
Eur J Obstet Gynecol Reprod Biol 2021 Sep;264:358-362. Epub 2021 Jul 28 doi: 10.1016/j.ejogrb.2021.07.046. PMID: 34391051
Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Parvovirus B19.
Young NS, Brown KE
N Engl J Med 2004 Feb 5;350(6):586-97. doi: 10.1056/NEJMra030840. PMID: 14762186

Therapy

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Common Skin Rashes in Children.
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Human parvovirus B19.
Am J Transplant 2004 Nov;4 Suppl 10:92-4. doi: 10.1111/j.1600-6135.2004.00731.x. PMID: 15504221
Transfusion-transmitted disease.
Lee CA
Baillieres Clin Haematol 1996 Jun;9(2):369-94. doi: 10.1016/s0950-3536(96)80069-2. PMID: 8800511

Prognosis

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Common Skin Rashes in Children.
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
Erythema infectiosum.
Vafaie J, Schwartz RA
J Cutan Med Surg 2005 Aug;9(4):159-61. doi: 10.1007/s10227-005-0101-8. PMID: 16502203
Parvovirus B19 infections.
Vafaie J, Schwartz RA
Int J Dermatol 2004 Oct;43(10):747-9. doi: 10.1111/j.1365-4632.2004.02413.x. PMID: 15485533
Transfusion-transmitted disease.
Lee CA
Baillieres Clin Haematol 1996 Jun;9(2):369-94. doi: 10.1016/s0950-3536(96)80069-2. PMID: 8800511

Clinical prediction guides

An unusual outbreak of parvovirus B19 infections, France, 2023 to 2024.
d'Humières C, Fouillet A, Verdurme L, Lakoussan SB, Gallien Y, Coignard C, Hervo M, Ebel A, Soares A, Visseaux B, Maire B, Juan PH, Parent du Châtelet I, Guthmann JP, Durand J
Euro Surveill 2024 Jun;29(25) doi: 10.2807/1560-7917.ES.2024.29.25.2400339. PMID: 38904112Free PMC Article
Epidemic of parvovirus B19 and disease severity in pregnant people, Denmark, January to March 2024.
Nordholm AC, Trier Møller F, Fischer Ravn S, Flink Sørensen L, Moltke-Prehn A, Elskær Mollerup J, Funk T, Sperling L, Jeyaratnam U, Træholt Franck K, Hjort-Pedersen K, Hjørnet Kamper C, Thoft Nielsen R, Jokelainen P, Wessman M
Euro Surveill 2024 Jun;29(24) doi: 10.2807/1560-7917.ES.2024.29.24.2400299. PMID: 38873795Free PMC Article
Hematologic Manifestations of Parvovirus B19 Infection.
Algwaiz G, Alharbi A, Alsehaim K, Alahmari A, El Fakih R, Aljurf M
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):316-322. doi: 10.56875/2589-0646.1031. PMID: 37363985
Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study.
Kosian P, Hellmund A, Geipel A, Bald R, Geist OM, Böckenhoff P, Jimenez-Cruz J, Deja M, Strizek B, Berg C, Gembruch U
Arch Gynecol Obstet 2023 Jul;308(1):117-125. Epub 2022 Aug 2 doi: 10.1007/s00404-022-06712-z. PMID: 35916962Free PMC Article
Erythema infectiosum; clinical and epidemiological observations.
PHILLIPS IE
South Med J 1954 Mar;47(3):253-6. doi: 10.1097/00007611-195403000-00017. PMID: 13146354

Recent systematic reviews

Mortality Rates and autopsy findings in fat embolism syndrome complicating sickle cell disease.
Samaee S, Samaee S, Mihalca D, Fitzgerald L, Ahmed A, Hall J, Tsitsikas DA
J Clin Pathol 2023 Jul;76(7):497-500. Epub 2023 Feb 27 doi: 10.1136/jcp-2023-208763. PMID: 36849230
Neurological Manifestations Associated with Parvovirus B19 Infection in Immunocompetent Children: Case Series and Systematic Review.
Monteiro VS, Baía-da-Silva DC, Silva VA, Pivoto João GA, Marinho EPM, Cubas-Vega NC, Val FFA, Perez-Gomez AS, Monte RL, Mota A, Lacerda MVG, Souza Bastos M
J Trop Pediatr 2021 Aug 27;67(4) doi: 10.1093/tropej/fmab078. PMID: 34545404
Are Daycare Workers at a Higher Risk of Parvovirus B19 Infection? A Systematic Review and Meta-Analysis.
Romero Starke K, Kofahl M, Freiberg A, Schubert M, Groß ML, Schmauder S, Hegewald J, Kämpf D, Stranzinger J, Nienhaus A, Seidler A
Int J Environ Res Public Health 2019 Apr 17;16(8) doi: 10.3390/ijerph16081392. PMID: 30999694Free PMC Article
Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis.
Bascietto F, Liberati M, Murgano D, Buca D, Iacovelli A, Flacco ME, Manzoli L, Familiari A, Scambia G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Nov;52(5):569-576. doi: 10.1002/uog.19092. PMID: 29785793

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