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Childhood-onset schizophrenia

MedGen UID:
48576
Concept ID:
C0036346
Mental or Behavioral Dysfunction
Synonym: Childhood schizophrenia
SNOMED CT: Very early-onset schizophrenia (1335862003); VEOS - very early-onset schizophrenia (1335862003); Childhood-onset schizophrenia (1335862003); COS - childhood-onset schizophrenia (1335862003)
 
Monarch Initiative: MONDO:0957430

Definition

A rare neurologic disease with psychiatric involvement with characteristics of prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Giannitelli M, Consoli A, Raffin M, Jardri R, Levinson DF, Cohen D, Laurent-Levinson C
Schizophr Res 2018 Feb;192:39-49. Epub 2017 May 16 doi: 10.1016/j.schres.2017.05.011. PMID: 28526280

Recent clinical studies

Etiology

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Forsyth JK, Asarnow RF
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):157-170. Epub 2019 Oct 17 doi: 10.1016/j.chc.2019.08.007. PMID: 31708045Free PMC Article
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Gogtay N, Rapoport JL
J Am Acad Child Adolesc Psychiatry 2008 Oct;47(10):1120-4. Epub 2009 Aug 21 doi: 10.1097/CHI.0b013e31817eed7a. PMID: 20566189

Diagnosis

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Hatila S, Solanki G
Prim Care Companion CNS Disord 2020 May 28;22(3) doi: 10.4088/PCC.19l02515. PMID: 32470234
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Asarnow JR
J Child Psychol Psychiatry 1994 Nov;35(8):1345-71. doi: 10.1111/j.1469-7610.1994.tb01280.x. PMID: 7868633

Therapy

Correll CU, Arango C, Fagerlund B, Galderisi S, Kas MJ, Leucht S
Eur Neuropsychopharmacol 2024 May;82:57-71. Epub 2024 Mar 15 doi: 10.1016/j.euroneuro.2024.02.005. PMID: 38492329
Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Kennedy E, Kumar A, Datta SS
Schizophr Bull 2007 Sep;33(5):1082-3. Epub 2007 Aug 1 doi: 10.1093/schbul/sbm080. PMID: 17670793Free PMC Article
Gordon CT
New Dir Ment Health Serv 1992 Summer;(54):71-5. doi: 10.1002/yd.23319925414. PMID: 1352624

Prognosis

Driver DI, Thomas S, Gogtay N, Rapoport JL
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):71-90. doi: 10.1016/j.chc.2019.08.017. PMID: 31708054
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Ordóñez AE, Sastry NV, Gogtay N
CNS Spectr 2015 Aug;20(4):442-50. doi: 10.1017/S1092852915000437. PMID: 26234702
Remschmidt H, Theisen F
Neuropsychobiology 2012;66(1):63-9. Epub 2012 Jul 13 doi: 10.1159/000338548. PMID: 22797279
Mattai A, Miller R, Weisinger B, Greenstein D, Bakalar J, Tossell J, David C, Wassermann EM, Rapoport J, Gogtay N
Brain Stimul 2011 Oct;4(4):275-80. Epub 2011 Feb 1 doi: 10.1016/j.brs.2011.01.001. PMID: 22032743Free PMC Article

Clinical prediction guides

Alkelai A, Greenbaum L, Shohat S, Povysil G, Malakar A, Ren Z, Motelow JE, Schechter T, Draiman B, Chitrit-Raveh E, Hughes D, Jobanputra V, Shifman S, Goldstein DB, Kohn Y
Schizophr Res 2023 Feb;252:138-145. Epub 2023 Jan 14 doi: 10.1016/j.schres.2022.12.033. PMID: 36645932
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Craddock KES, Zhou X, Liu S, Gochman P, Dickinson D, Rapoport JL
Schizophr Res 2018 Jul;197:71-77. Epub 2017 Nov 13 doi: 10.1016/j.schres.2017.10.045. PMID: 29146021Free PMC Article
Ahn K, An SS, Shugart YY, Rapoport JL
Mol Psychiatry 2016 Jan;21(1):94-6. Epub 2014 Dec 16 doi: 10.1038/mp.2014.158. PMID: 25510512
Sholevar EH, Baron DA, Hardie TL
J Child Adolesc Psychopharmacol 2000 Summer;10(2):69-78. doi: 10.1089/cap.2000.10.69. PMID: 10933117

Recent systematic reviews

Zaccaria V, Ardizzone I, Pisani F, Raballo A, Poletti M
Clin Child Psychol Psychiatry 2025 Jan;30(1):5-19. Epub 2024 Sep 19 doi: 10.1177/13591045241285486. PMID: 39299241
Adnan M, Motiwala F, Trivedi C, Sultana T, Mansuri Z, Jain S
J Child Adolesc Psychopharmacol 2022 Feb;32(1):2-11. Epub 2022 Jan 28 doi: 10.1089/cap.2021.0092. PMID: 35099269
Kennedy E, Kumar A, Datta SS
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD004027. doi: 10.1002/14651858.CD004027.pub2. PMID: 17636744Free PMC Article

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