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Intestinal polyp

MedGen UID:
9526
•Concept ID:
C0021846
•
Anatomical Abnormality
Synonym: Intestinal polyp (disease)
SNOMED CT: Intestinal polyp (254588001); Polyp of intestine (254588001); Bowel polyp (254588001)
 
HPO: HP:0005266
Monarch Initiative: MONDO:0005288

Definition

A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base. [from HPO]

Professional guidelines

PubMed

Combined analysis of serum SAP and PRSS2 for the differential diagnosis of CD and UC.
Wang W, Wu L, Wu X, Li K, Li T, Xu B, Liu W
Clin Chim Acta 2021 Mar;514:8-14. Epub 2020 Dec 15 doi: 10.1016/j.cca.2020.12.014. PMID: 33333044
Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL.
Woo JK, Kang JH, Jang YS, Ro S, Cho JM, Kim HM, Lee SJ, Oh SH
Oncol Rep 2015 Apr;33(4):1947-55. Epub 2015 Feb 10 doi: 10.3892/or.2015.3793. PMID: 25672292
Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer.
Buchanan FG, Holla V, Katkuri S, Matta P, DuBois RN
Cancer Res 2007 Oct 1;67(19):9380-8. doi: 10.1158/0008-5472.CAN-07-0710. PMID: 17909047

Recent clinical studies

Etiology

Yogurt Prevents Colorectal Tumorigenesis in Apc(Min/+) Mice.
Li X, Qian J, Liu Q, Guo M, Zhang H, Li H, Chen W
Mol Nutr Food Res 2024 May;68(10):e2300737. Epub 2024 May 3 doi: 10.1002/mnfr.202300737. PMID: 38700077
Factors Associated with Intestinal Polyp Recurrence after Electroresection.
Jin J, Yan B, Yang S, du M
J Coll Physicians Surg Pak 2023 Jun;33(6):633-637. doi: 10.29271/jcpsp.2023.06.633. PMID: 37300257
Factors Affecting Adenoma Risk Level in Patients with Intestinal Polyp and Association Analysis.
Dai Y, Chen W, Xu X, Chen J, Mo W, Chen Y, Xu S
J Healthc Eng 2022;2022:9479563. Epub 2022 Jan 15 doi: 10.1155/2022/9479563. PMID: 35075394Free PMC Article
Genome-wide DNA methylation profiling and gut flora analysis in intestinal polyps patients.
Liu L, Chen Y, Liu T, Yu J, Ma L, Wu H
Eur J Gastroenterol Hepatol 2021 Aug 1;33(8):1071-1081. doi: 10.1097/MEG.0000000000002181. PMID: 34213504
Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice.
Mutoh M, Niho N, Wakabayashi K
Biol Chem 2006 Apr;387(4):381-5. doi: 10.1515/BC.2006.051. PMID: 16606335

Diagnosis

Artificial intelligence in intestinal polyp and colorectal cancer prediction.
Sharma A, Kumar R, Yadav G, Garg P
Cancer Lett 2023 Jul 1;565:216238. Epub 2023 May 19 doi: 10.1016/j.canlet.2023.216238. PMID: 37211068
Factors Affecting Adenoma Risk Level in Patients with Intestinal Polyp and Association Analysis.
Dai Y, Chen W, Xu X, Chen J, Mo W, Chen Y, Xu S
J Healthc Eng 2022;2022:9479563. Epub 2022 Jan 15 doi: 10.1155/2022/9479563. PMID: 35075394Free PMC Article
Combined analysis of serum SAP and PRSS2 for the differential diagnosis of CD and UC.
Wang W, Wu L, Wu X, Li K, Li T, Xu B, Liu W
Clin Chim Acta 2021 Mar;514:8-14. Epub 2020 Dec 15 doi: 10.1016/j.cca.2020.12.014. PMID: 33333044
Rare presentation of small bowel intussusception in childhood.
Chan CY, Tsang PK, Chu PY, Wong YC
Pediatr Int 2016 Jul;58(7):642-5. Epub 2016 Apr 26 doi: 10.1111/ped.12926. PMID: 27117717
Hamartomatous small intestinal polyp from tuberous sclerosis.
Goldberg E
J Pediatr Gastroenterol Nutr 2011 Dec;53(6):585. doi: 10.1097/MPG.0b013e318225f56e. PMID: 21637129

Therapy

Artificial intelligence in intestinal polyp and colorectal cancer prediction.
Sharma A, Kumar R, Yadav G, Garg P
Cancer Lett 2023 Jul 1;565:216238. Epub 2023 May 19 doi: 10.1016/j.canlet.2023.216238. PMID: 37211068
Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling.
Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M
Carcinogenesis 2021 Feb 11;42(1):148-158. doi: 10.1093/carcin/bgaa084. PMID: 32710739
Surveillance using capsule endoscopy is safe in post-colectomy patients with familial adenomatous polyposis: a prospective Japanese study.
Matsumoto M, Nakajima T, Kakugawa Y, Sakamoto T, Kuribayashi S, Otake Y, Matsuda T, Kanemitsu Y, Taniguchi H, Saito Y
Fam Cancer 2016 Jan;15(1):75-83. doi: 10.1007/s10689-015-9844-6. PMID: 26450841
Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice.
Mutoh M, Niho N, Wakabayashi K
Biol Chem 2006 Apr;387(4):381-5. doi: 10.1515/BC.2006.051. PMID: 16606335
COX selectivity and animal models for colon cancer.
Oshima M, Taketo MM
Curr Pharm Des 2002;8(12):1021-34. doi: 10.2174/1381612023394953. PMID: 11945149

Prognosis

β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of Apc(Min/+) Mice.
Velasco-Sampedro EA, Sánchez-Vicente C, Caloca MJ
Molecules 2025 Feb 11;30(4) doi: 10.3390/molecules30040824. PMID: 40005135Free PMC Article
Artificial intelligence in intestinal polyp and colorectal cancer prediction.
Sharma A, Kumar R, Yadav G, Garg P
Cancer Lett 2023 Jul 1;565:216238. Epub 2023 May 19 doi: 10.1016/j.canlet.2023.216238. PMID: 37211068
Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer.
Liu W, Rodgers GP
Cancer Metastasis Rev 2016 Jun;35(2):201-12. doi: 10.1007/s10555-016-9624-2. PMID: 27178440
Safe and efficient colorectal endoscopic submucosal dissection in European settings: is successful implementation of the procedure possible?
Spychalski M, Dziki A
Dig Endosc 2015 Mar;27(3):368-73. Epub 2014 Oct 28 doi: 10.1111/den.12353. PMID: 25181427
Alu-based cell-free DNA: a potential complementary biomarker for diagnosis of colorectal cancer.
Qi J, Qian C, Shi W, Wu X, Jing R, Zhang L, Wang Z, Ju S
Clin Biochem 2013 Jan;46(1-2):64-9. Epub 2012 Sep 10 doi: 10.1016/j.clinbiochem.2012.08.026. PMID: 22975639

Clinical prediction guides

Yogurt Prevents Colorectal Tumorigenesis in Apc(Min/+) Mice.
Li X, Qian J, Liu Q, Guo M, Zhang H, Li H, Chen W
Mol Nutr Food Res 2024 May;68(10):e2300737. Epub 2024 May 3 doi: 10.1002/mnfr.202300737. PMID: 38700077
Factors Associated with Intestinal Polyp Recurrence after Electroresection.
Jin J, Yan B, Yang S, du M
J Coll Physicians Surg Pak 2023 Jun;33(6):633-637. doi: 10.29271/jcpsp.2023.06.633. PMID: 37300257
Artificial intelligence in intestinal polyp and colorectal cancer prediction.
Sharma A, Kumar R, Yadav G, Garg P
Cancer Lett 2023 Jul 1;565:216238. Epub 2023 May 19 doi: 10.1016/j.canlet.2023.216238. PMID: 37211068
Extending the phenotypes associated with DICER1 mutations.
Foulkes WD, Bahubeshi A, Hamel N, Pasini B, Asioli S, Baynam G, Choong CS, Charles A, Frieder RP, Dishop MK, Graf N, Ekim M, Bouron-Dal Soglio D, Arseneau J, Young RH, Sabbaghian N, Srivastava A, Tischkowitz MD, Priest JR
Hum Mutat 2011 Dec;32(12):1381-4. Epub 2011 Oct 11 doi: 10.1002/humu.21600. PMID: 21882293
Prevention of colorectal cancer through the use of COX-2 selective inhibitors.
Peek RM Jr
Cancer Chemother Pharmacol 2004 Sep;54 Suppl 1:S50-6. doi: 10.1007/s00280-004-0887-x. PMID: 15309515

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