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Diabetic retinopathy

MedGen UID:
3786
•Concept ID:
C0011884
•
Disease or Syndrome
Synonyms: Diabetic Retinopathies; Diabetic Retinopathy; Retinopathies, Diabetic; Retinopathy, Diabetic
SNOMED CT: Retinal abnormality - diabetes-related (4855003); DR - Diabetic retinopathy (4855003); Retinopathy due to diabetes mellitus (4855003); Diabetic retinopathy (4855003)
 
Monarch Initiative: MONDO:0005266

Definition

A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness. [from NCI]

Professional guidelines

PubMed

Diabetic retinopathy: Screening, prevention, and treatment.
Chong DD, Das N, Singh RP
Cleve Clin J Med 2024 Aug 1;91(8):503-510. doi: 10.3949/ccjm.91a.24028. PMID: 39089852
American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.
Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, Chandrasekaran S, DeFronzo RA, Einhorn D, Galindo RJ, Gardner TW, Garg R, Garvey WT, Hirsch IB, Hurley DL, Izuora K, Kosiborod M, Olson D, Patel SB, Pop-Busui R, Sadhu AR, Samson SL, Stec C, Tamborlane WV Jr, Tuttle KR, Twining C, Vella A, Vellanki P, Weber SL
Endocr Pract 2022 Oct;28(10):923-1049. Epub 2022 Aug 11 doi: 10.1016/j.eprac.2022.08.002. PMID: 35963508Free PMC Article
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Recent clinical studies

Etiology

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy.
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Diabetic Retinopathy Preferred Practice Pattern®.
Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA, Ying GS
Ophthalmology 2020 Jan;127(1):P66-P145. Epub 2019 Sep 25 doi: 10.1016/j.ophtha.2019.09.025. PMID: 31757498
Diabetic retinopathy.
Cheung N, Mitchell P, Wong TY
Lancet 2010 Jul 10;376(9735):124-36. Epub 2010 Jun 26 doi: 10.1016/S0140-6736(09)62124-3. PMID: 20580421
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article
Diabetic retinopathy.
Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R; American Diabetes Association
Diabetes Care 2003 Jan;26(1):226-9. doi: 10.2337/diacare.26.1.226. PMID: 12502685

Diagnosis

Diabetic retinopathy for the non-ophthalmologist.
Fung TH, Patel B, Wilmot EG, Amoaku WM
Clin Med (Lond) 2022 Mar;22(2):112-116. doi: 10.7861/clinmed.2021-0792. PMID: 35304370Free PMC Article
Proliferative diabetic retinopathy (PDR).
Chaudhary S, Zaveri J, Becker N
Dis Mon 2021 May;67(5):101140. Epub 2021 Feb 3 doi: 10.1016/j.disamonth.2021.101140. PMID: 33546872
Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy.
Lin KY, Hsih WH, Lin YB, Wen CY, Chang TJ
J Diabetes Investig 2021 Aug;12(8):1322-1325. Epub 2021 Jan 14 doi: 10.1111/jdi.13480. PMID: 33316144Free PMC Article
Diabetic retinopathy.
Cheung N, Mitchell P, Wong TY
Lancet 2010 Jul 10;376(9735):124-36. Epub 2010 Jun 26 doi: 10.1016/S0140-6736(09)62124-3. PMID: 20580421
Diabetic retinopathy: Early diagnosis and effective treatment.
Kollias AN, Ulbig MW
Dtsch Arztebl Int 2010 Feb;107(5):75-83; quiz 84. Epub 2010 Feb 5 doi: 10.3238/arztebl.2010.0075. PMID: 20186318Free PMC Article

Therapy

GLP-1 receptor agonists and diabetic retinopathy: A meta-analysis of randomized clinical trials.
Kapoor I, Sarvepalli SM, D'Alessio D, Grewal DS, Hadziahmetovic M
Surv Ophthalmol 2023 Nov-Dec;68(6):1071-1083. Epub 2023 Jul 16 doi: 10.1016/j.survophthal.2023.07.002. PMID: 37454782
Semaglutide and Diabetic Retinopathy Risk in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials.
Wang F, Mao Y, Wang H, Liu Y, Huang P
Clin Drug Investig 2022 Jan;42(1):17-28. Epub 2021 Dec 11 doi: 10.1007/s40261-021-01110-w. PMID: 34894326
Safety of Semaglutide.
Smits MM, Van Raalte DH
Front Endocrinol (Lausanne) 2021;12:645563. Epub 2021 Jul 7 doi: 10.3389/fendo.2021.645563. PMID: 34305810Free PMC Article
Metformin.
Bloomgarden ZT
Diabetes Care 1995 Jul;18(7):1078-80. doi: 10.2337/diacare.18.7.1078. PMID: 7555549
Diabetes Control and Complications Trial (DCCT): results of feasibility study. The DCCT Research Group.
Diabetes Care 1987 Jan-Feb;10(1):1-19. doi: 10.2337/diacare.10.1.1. PMID: 2882967

Prognosis

The Impact of COVID-19 on Diabetic Retinopathy Monitoring and Treatment.
Ahmed I, Liu TYA
Curr Diab Rep 2021 Sep 8;21(10):40. doi: 10.1007/s11892-021-01411-6. PMID: 34495377Free PMC Article
Diabetic Macular Edema.
Bandello F, Battaglia Parodi M, Lanzetta P, Loewenstein A, Massin P, Menchini F, Veritti D
Dev Ophthalmol 2017;58:102-138. Epub 2017 Mar 28 doi: 10.1159/000455277. PMID: 28351052
Blood Pressure Control for Diabetic Retinopathy.
Anger WH Jr
Am J Nurs 2016 Jan;116(1):56. doi: 10.1097/01.NAJ.0000476171.74165.c7. PMID: 26710151
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Diabetic retinopathy.
Klein R
Annu Rev Public Health 1996;17:137-58. doi: 10.1146/annurev.pu.17.050196.001033. PMID: 8724221

Clinical prediction guides

Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.
Nayak SS, Kuriyakose D, Polisetty LD, Patil AA, Ameen D, Bonu R, Shetty SP, Biswas P, Ulrich MT, Letafatkar N, Habibi A, Keivanlou MH, Nobakht S, Alotaibi A, Hassanipour S, Amini-Salehi E
Cardiovasc Diabetol 2024 Aug 23;23(1):310. doi: 10.1186/s12933-024-02392-y. PMID: 39180024Free PMC Article
Association Between Cardiovascular Health and Retinopathy in US Adults: From NHANES 2005-2008.
Liu X, Chang Y, Li Y, Liu Y, Chen N, Cui J
Am J Ophthalmol 2024 Oct;266:56-67. Epub 2024 May 17 doi: 10.1016/j.ajo.2024.05.019. PMID: 38762091
Prevalence and risk factors of diabetic peripheral neuropathy: A population-based cross-sectional study in China.
Wang W, Ji Q, Ran X, Li C, Kuang H, Yu X, Fang H, Yang J, Liu J, Xue Y, Feng B, Lei M, Zhu D
Diabetes Metab Res Rev 2023 Nov;39(8):e3702. Epub 2023 Jul 25 doi: 10.1002/dmrr.3702. PMID: 37490047
Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference.
Wan H, Wang Y, Xiang Q, Fang S, Chen Y, Chen C, Zhang W, Zhang H, Xia F, Wang N, Lu Y
Cardiovasc Diabetol 2020 Jul 31;19(1):118. doi: 10.1186/s12933-020-01095-4. PMID: 32736628Free PMC Article
Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR
JAMA 2016 Dec 13;316(22):2402-2410. doi: 10.1001/jama.2016.17216. PMID: 27898976

Recent systematic reviews

Vitamin D and Ocular Diseases: A Systematic Review.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045: Systematic Review and Meta-analysis.
Teo ZL, Tham YC, Yu M, Chee ML, Rim TH, Cheung N, Bikbov MM, Wang YX, Tang Y, Lu Y, Wong IY, Ting DSW, Tan GSW, Jonas JB, Sabanayagam C, Wong TY, Cheng CY
Ophthalmology 2021 Nov;128(11):1580-1591. Epub 2021 May 1 doi: 10.1016/j.ophtha.2021.04.027. PMID: 33940045
Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.
Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E
Ann Intern Med 2020 Aug 18;173(4):278-286. Epub 2020 Jun 30 doi: 10.7326/M20-0864. PMID: 32598218
Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis (†).
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y
Ann Med 2017 Mar;49(2):106-116. Epub 2016 Nov 3 doi: 10.1080/07853890.2016.1231932. PMID: 27585063
Global prevalence and major risk factors of diabetic retinopathy.
Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY; Meta-Analysis for Eye Disease (META-EYE) Study Group
Diabetes Care 2012 Mar;35(3):556-64. Epub 2012 Feb 1 doi: 10.2337/dc11-1909. PMID: 22301125Free PMC Article

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