U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ectopic tissue

MedGen UID:
40280
•Concept ID:
C0008519
•
Pathologic Function
Synonym: Heterotopia
SNOMED CT: Heterotopic tissue (128490007); Heterotopia (128490007); Choristoma (417338002); Heterotopic structure, either congenital or acquired (128490007); Ectopic tissue (719446000); Aberrant tissue (719446000); Ectopia (719446000)

Definition

Proliferation of normal tissue in an anatomic site in which this particular type of tissue is not normally present. [from NCI]

Professional guidelines

PubMed

Drug repurposing for targeting fibronectin in treatment of endometriosis and cancers.
Mahdian S, Moini A, Esfandiari F, Shahhoseini M
J Biomol Struct Dyn 2025 Jan;43(1):144-160. Epub 2023 Nov 10 doi: 10.1080/07391102.2023.2280677. PMID: 37948310
Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages.
Ringden O, Le Blanc K
Best Pract Res Clin Haematol 2011 Mar;24(1):65-72. Epub 2011 Feb 25 doi: 10.1016/j.beha.2011.01.003. PMID: 21396594

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature.
Grisdale M, Alghamdi S, Boutross-Tadross O, Luketic L
J Obstet Gynaecol Can 2021 Jan;43(1):85-87. Epub 2020 Jun 4 doi: 10.1016/j.jogc.2020.04.018. PMID: 32739356
Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis.
Parkin KL, Fazleabas AT
Am J Reprod Immunol 2016 Mar;75(3):411-7. Epub 2016 Jan 19 doi: 10.1111/aji.12487. PMID: 26782366Free PMC Article
Heterotopic ossification after total hip replacement.
Warren SB
Orthop Rev 1990 Jul;19(7):603-11. PMID: 2116617
Meckel's diverticulum in adults.
Murali VP, Divakar D, Thachil MV, Raghu CG, Jacob MG
J Indian Med Assoc 1989 May;87(5):116-8. PMID: 2600435

Diagnosis

Neuropathology Entities Involving the Sinonasal Tract.
Roberts KF, Dahiya SM
Surg Pathol Clin 2024 Dec;17(4):733-748. Epub 2024 Aug 17 doi: 10.1016/j.path.2024.07.011. PMID: 39489560
Biomarkers of endometriosis.
Pant A, Moar K, K Arora T, Maurya PK
Clin Chim Acta 2023 Sep 1;549:117563. Epub 2023 Sep 20 doi: 10.1016/j.cca.2023.117563. PMID: 37739024
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
The Origin and Pathogenesis of Endometriosis.
Wang Y, Nicholes K, Shih IM
Annu Rev Pathol 2020 Jan 24;15:71-95. Epub 2019 Sep 3 doi: 10.1146/annurev-pathmechdis-012419-032654. PMID: 31479615Free PMC Article
Benign vulvar tumors.
Hood AF, Lumadue J
Dermatol Clin 1992 Apr;10(2):371-85. PMID: 1318812

Therapy

Ciliated respiratory epithelium encapsulating Pseudomonas brain abscess due to prior trauma.
Jena NK, Khine J, Khosrodad N, Krishnamoorthy G
BMJ Case Rep 2021 Jan 15;14(1) doi: 10.1136/bcr-2020-238836. PMID: 33452072Free PMC Article
Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature.
Grisdale M, Alghamdi S, Boutross-Tadross O, Luketic L
J Obstet Gynaecol Can 2021 Jan;43(1):85-87. Epub 2020 Jun 4 doi: 10.1016/j.jogc.2020.04.018. PMID: 32739356
Differentiated thyroid carcinoma in lingual thyroid.
Sturniolo G, Violi MA, Galletti B, Baldari S, Campennì A, Vermiglio F, Moleti M
Endocrine 2016 Jan;51(1):189-98. Epub 2015 May 19 doi: 10.1007/s12020-015-0593-y. PMID: 25987346
Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms.
Basu J, Assaf BT, Bertram TA, Rao M
Toxicol Pathol 2015 Jan;43(1):115-25. Epub 2014 Dec 4 doi: 10.1177/0192623314559104. PMID: 25476796
Medical treatments for endometriosis.
Kappou D, Matalliotakis M, Matalliotakis I
Minerva Ginecol 2010 Oct;62(5):415-32. PMID: 20938427

Prognosis

Tertiary lymphoid structures in endometriosis.
Zutautas KB, Yolmo P, Xu M, Childs T, Koti M, Tayade C
F S Sci 2024 Nov;5(4):335-341. Epub 2024 Oct 5 doi: 10.1016/j.xfss.2024.10.001. PMID: 39370108
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature.
Grisdale M, Alghamdi S, Boutross-Tadross O, Luketic L
J Obstet Gynaecol Can 2021 Jan;43(1):85-87. Epub 2020 Jun 4 doi: 10.1016/j.jogc.2020.04.018. PMID: 32739356
Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat?
Gaborit B, Sengenes C, Ancel P, Jacquier A, Dutour A
Compr Physiol 2017 Jun 18;7(3):1051-1082. doi: 10.1002/cphy.c160034. PMID: 28640452
Meckel's diverticulum in adults.
Murali VP, Divakar D, Thachil MV, Raghu CG, Jacob MG
J Indian Med Assoc 1989 May;87(5):116-8. PMID: 2600435

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1-Deficient Mice.
Cheng Z, O'Brien K, Howe J, Sullivan C, Schrier D, Lynch A, Jungles S, Sabbagh Y, Thompson D
J Bone Miner Res 2021 Aug;36(8):1594-1604. Epub 2021 May 5 doi: 10.1002/jbmr.4315. PMID: 33900645
Complications Following Stem Cell Therapy in Inflammatory Bowel Disease.
Wei H, Liu X, Ouyang C, Zhang J, Chen S, Lu F, Chen L
Curr Stem Cell Res Ther 2017;12(6):471-475. doi: 10.2174/1574888X12666170315105556. PMID: 28302045
Differentiated thyroid carcinoma in lingual thyroid.
Sturniolo G, Violi MA, Galletti B, Baldari S, Campennì A, Vermiglio F, Moleti M
Endocrine 2016 Jan;51(1):189-98. Epub 2015 May 19 doi: 10.1007/s12020-015-0593-y. PMID: 25987346
The endometrium in adenomyosis.
Benagiano G, Brosens I
Womens Health (Lond) 2012 May;8(3):301-12. doi: 10.2217/whe.12.8. PMID: 22554177

Recent systematic reviews

Ectopic mammary tissue in vulva: case report and systematic literature review.
Buitrago-Flechas SM, Barrera-Latorre SJ, Morante-Caicedo C
Rev Colomb Obstet Ginecol 2021 Sep 30;72(3):271-290. doi: 10.18597/rcog.3593. PMID: 34851570Free PMC Article
Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition.
Fisher SA, Cutler A, Doree C, Brunskill SJ, Stanworth SJ, Navarrete C, Girdlestone J
Cochrane Database Syst Rev 2019 Jan 30;1(1):CD009768. doi: 10.1002/14651858.CD009768.pub2. PMID: 30697701Free PMC Article
Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.
Hansen CC, Søreide K
Medicine (Baltimore) 2018 Aug;97(35):e12154. doi: 10.1097/MD.0000000000012154. PMID: 30170459Free PMC Article
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z
Am J Reprod Immunol 2017 Apr;77(4) Epub 2017 Jan 25 doi: 10.1111/aji.12622. PMID: 28120482

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...