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Abnormality of urine calcium concentration

MedGen UID:
869017
•Concept ID:
C4023434
•
Finding
Synonyms: Abnormality of urine Ca concentration; Abnormality of urine Ca2+ concentration
 
HPO: HP:0011280

Definition

An abnormality of calcium concentration in the urine. [from HPO]

Conditions with this feature

Primary hyperoxaluria, type II
MedGen UID:
120616
•Concept ID:
C0268165
•
Disease or Syndrome
Primary hyperoxaluria type 2 (PH2), caused by deficiency of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GR/HPR), is characterized by recurrent nephrolithiasis (deposition of calcium oxalate in the renal pelvis / urinary tract), nephrocalcinosis (deposition of calcium oxalate in the renal parenchyma), and end-stage kidney disease (ESKD). After ESKD, oxalosis (widespread tissue deposition of calcium oxalate) usually develops. Symptom onset is typically in childhood.
See: Condition Record
Primary hyperoxaluria, type II

Professional guidelines

PubMed

Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Renal stone disease: Causes, evaluation and medical treatment.
Heilberg IP, Schor N
Arq Bras Endocrinol Metabol 2006 Aug;50(4):823-31. doi: 10.1590/s0004-27302006000400027. PMID: 17117307
Lopinavir/ritonavir: a review of its use in the management of HIV infection.
Cvetkovic RS, Goa KL
Drugs 2003;63(8):769-802. doi: 10.2165/00003495-200363080-00004. PMID: 12662125

Recent clinical studies

Etiology

Incomplete Distal Renal Tubular Acidosis and Kidney Stones.
Fuster DG, Moe OW
Adv Chronic Kidney Dis 2018 Jul;25(4):366-374. doi: 10.1053/j.ackd.2018.05.007. PMID: 30139463Free PMC Article
Bacteria, Bones, and Stones: Managing Complications of Short Bowel Syndrome.
Johnson E, Vu L, Matarese LE
Nutr Clin Pract 2018 Aug;33(4):454-466. Epub 2018 Jun 21 doi: 10.1002/ncp.10113. PMID: 29926935
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism.
Chattopadhyay N, Mithal A, Brown EM
Endocr Rev 1996 Aug;17(4):289-307. doi: 10.1210/edrv-17-4-289. PMID: 8854047
Idiopathic calcium oxalate urolithiasis.
Smith LH
Endocrinol Metab Clin North Am 1990 Dec;19(4):937-47. PMID: 2081520

Diagnosis

Incomplete Distal Renal Tubular Acidosis and Kidney Stones.
Fuster DG, Moe OW
Adv Chronic Kidney Dis 2018 Jul;25(4):366-374. doi: 10.1053/j.ackd.2018.05.007. PMID: 30139463Free PMC Article
Fahr's syndrome: literature review of current evidence.
Saleem S, Aslam HM, Anwar M, Anwar S, Saleem M, Saleem A, Rehmani MA
Orphanet J Rare Dis 2013 Oct 8;8:156. doi: 10.1186/1750-1172-8-156. PMID: 24098952Free PMC Article
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Medullary sponge kidney associated with congenital hemihypertrophy.
Indridason OS, Thomas L, Berkoben M
J Am Soc Nephrol 1996 Aug;7(8):1123-30. doi: 10.1681/ASN.V781123. PMID: 8866402
Idiopathic calcium oxalate urolithiasis.
Smith LH
Endocrinol Metab Clin North Am 1990 Dec;19(4):937-47. PMID: 2081520

Therapy

Incomplete Distal Renal Tubular Acidosis and Kidney Stones.
Fuster DG, Moe OW
Adv Chronic Kidney Dis 2018 Jul;25(4):366-374. doi: 10.1053/j.ackd.2018.05.007. PMID: 30139463Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Effects of water balance, diet and antidiuretic-hormone administration on the renal excretion of water.
de Rouffignac C
Scand J Urol Nephrol Suppl 1999;202:31-5. doi: 10.1080/003655999750169411. PMID: 10573789
Lithium: a review of its pharmacokinetics, health effects, and toxicology.
Marcus WL
J Environ Pathol Toxicol Oncol 1994;13(2):73-9. PMID: 7884646

Prognosis

Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels.
Bersani I, Gasparroni G, Bashir M, Aboulgar H, Mufeed H, Iskander I, Kornacka M, Gruzfeld D, Dotta A, Campi F, Longo D, Savarese I, Braguglia A, Tina LG, Nigro F, Serpero L, Strozzi MC, Maconi A, Ianniello P, Di Battista C, D'Adamo E, Gavilanes D, Gazzolo D
Clin Chem Lab Med 2022 Oct 26;60(11):1745-1752. Epub 2022 Aug 18 doi: 10.1515/cclm-2022-0559. PMID: 35977430
Urinary minerals excretion among primary schoolchildren in Dubai-United Arab Emirates.
Al Ghali R, El-Mallah C, Obeid O, El-Saleh O, Smail L, Haroun D
PLoS One 2021;16(8):e0255195. Epub 2021 Aug 5 doi: 10.1371/journal.pone.0255195. PMID: 34351961Free PMC Article
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501

Clinical prediction guides

Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels.
Bersani I, Gasparroni G, Bashir M, Aboulgar H, Mufeed H, Iskander I, Kornacka M, Gruzfeld D, Dotta A, Campi F, Longo D, Savarese I, Braguglia A, Tina LG, Nigro F, Serpero L, Strozzi MC, Maconi A, Ianniello P, Di Battista C, D'Adamo E, Gavilanes D, Gazzolo D
Clin Chem Lab Med 2022 Oct 26;60(11):1745-1752. Epub 2022 Aug 18 doi: 10.1515/cclm-2022-0559. PMID: 35977430
Rhabdomyolysis.
Zimmerman JL, Shen MC
Chest 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016. PMID: 24008958
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
The role of Tamm-Horsfall glycoprotein and Nephrocalcin in calcium oxalate monohydrate crystallization processes.
Hess B
Scanning Microsc 1991 Sep;5(3):689-95; discussion 696. PMID: 1808706

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