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Abnormal homeostasis

MedGen UID:
868551
•Concept ID:
C4022950
•
Finding
HPO: HP:0012337

Definition

An anomaly in the processes involved in the maintenance of an internal equilibrium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal homeostasis

Professional guidelines

PubMed

Increasing numbers of CD19 + CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.
Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M
Int J Hematol 2021 Nov;114(5):580-590. Epub 2021 Jul 26 doi: 10.1007/s12185-021-03192-w. PMID: 34309815
Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia.
Drezner MK, Lyles KW, Haussler MR, Harrelson JM
J Clin Invest 1980 Nov;66(5):1020-32. doi: 10.1172/JCI109930. PMID: 6253520Free PMC Article

Recent clinical studies

Etiology

Porphyromonas gingivalis-induced autophagy exacerbates abnormal lung homeostasis: An in vivo and in vitro study.
Zhao Q, Li W, Li W, Yang H, Wang X, Ding Z, Liu Z, Wang Z
Arch Oral Biol 2025 Jan;169:106122. Epub 2024 Oct 29 doi: 10.1016/j.archoralbio.2024.106122. PMID: 39486274
Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.
Matsuoka M, Inoue T, Shinjo T, Miiji A, Tamashiro M, Oba K, Arima H, Arasaki O
Hypertens Res 2020 Aug;43(8):817-823. Epub 2020 Mar 17 doi: 10.1038/s41440-020-0427-z. PMID: 32203449
Blood metals concentration in type 1 and type 2 diabetics.
Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R
Biol Trace Elem Res 2013 Dec;156(1-3):79-90. Epub 2013 Nov 14 doi: 10.1007/s12011-013-9858-6. PMID: 24222606
The role of cytokines in skin aging.
Borg M, Brincat S, Camilleri G, Schembri-Wismayer P, Brincat M, Calleja-Agius J
Climacteric 2013 Oct;16(5):514-21. Epub 2013 May 31 doi: 10.3109/13697137.2013.802303. PMID: 23659624
Smoking and aortic diseases.
Kakafika AI, Mikhailidis DP
Circ J 2007 Aug;71(8):1173-80. doi: 10.1253/circj.71.1173. PMID: 17652877

Diagnosis

An Autocatalytic DNA Circuit Based on Hybridization Chain Assembly for Intracellular Imaging of Polynucleotide Kinase.
Wang Y, Chen Y, Wan Y, Hong C, Shang J, Li F, Liu X, Wang F
ACS Appl Mater Interfaces 2022 Jul 20;14(28):31727-31736. Epub 2022 Jul 5 doi: 10.1021/acsami.2c08523. PMID: 35786848
Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.
Matsuoka M, Inoue T, Shinjo T, Miiji A, Tamashiro M, Oba K, Arima H, Arasaki O
Hypertens Res 2020 Aug;43(8):817-823. Epub 2020 Mar 17 doi: 10.1038/s41440-020-0427-z. PMID: 32203449
Fluorescence imaging of metal ions implicated in diseases.
Qian X, Xu Z
Chem Soc Rev 2015 Jul 21;44(14):4487-93. doi: 10.1039/c4cs00292j. PMID: 25556818
Endothelial dysfunction and cardiovascular risk profile in long-term withdrawing alcoholics.
Di Gennaro C, Biggi A, Barilli AL, Fasoli E, Carra N, Novarini A, Delsignore R, Montanari A
J Hypertens 2007 Feb;25(2):367-73. doi: 10.1097/HJH.0b013e328010929c. PMID: 17211243
Can we distinguish anxiety from depression?
Baldwin DS, Evans DL, Hirschfeld RM, Kasper S
Psychopharmacol Bull 2002 Summer;36 Suppl 2:158-65. PMID: 12490832

Therapy

Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer's Disease.
Singh R, Panghal A, Jadhav K, Thakur A, Verma RK, Singh C, Goyal M, Kumar J, Namdeo AG
Mol Neurobiol 2024 Dec;61(12):10916-10940. Epub 2024 May 29 doi: 10.1007/s12035-024-04256-8. PMID: 38809370
Blood metals concentration in type 1 and type 2 diabetics.
Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R
Biol Trace Elem Res 2013 Dec;156(1-3):79-90. Epub 2013 Nov 14 doi: 10.1007/s12011-013-9858-6. PMID: 24222606
The role of cytokines in skin aging.
Borg M, Brincat S, Camilleri G, Schembri-Wismayer P, Brincat M, Calleja-Agius J
Climacteric 2013 Oct;16(5):514-21. Epub 2013 May 31 doi: 10.3109/13697137.2013.802303. PMID: 23659624
Smoking and aortic diseases.
Kakafika AI, Mikhailidis DP
Circ J 2007 Aug;71(8):1173-80. doi: 10.1253/circj.71.1173. PMID: 17652877
Mucus clearance and lung function in cystic fibrosis with hypertonic saline.
Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC
N Engl J Med 2006 Jan 19;354(3):241-50. doi: 10.1056/NEJMoa043891. PMID: 16421365

Prognosis

Increasing numbers of CD19 + CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.
Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M
Int J Hematol 2021 Nov;114(5):580-590. Epub 2021 Jul 26 doi: 10.1007/s12185-021-03192-w. PMID: 34309815
The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease.
Mayer O Jr, Seidlerová J, Vaněk J, Karnosová P, Bruthans J, Filipovský J, Wohlfahrt P, Cífková R, Windrichová J, Knapen MH, Drummen NE, Vermeer C
Int J Cardiol 2016 Jan 15;203:916-22. Epub 2015 Oct 31 doi: 10.1016/j.ijcard.2015.10.226. PMID: 26618253
Can we distinguish anxiety from depression?
Baldwin DS, Evans DL, Hirschfeld RM, Kasper S
Psychopharmacol Bull 2002 Summer;36 Suppl 2:158-65. PMID: 12490832

Clinical prediction guides

Porphyromonas gingivalis-induced autophagy exacerbates abnormal lung homeostasis: An in vivo and in vitro study.
Zhao Q, Li W, Li W, Yang H, Wang X, Ding Z, Liu Z, Wang Z
Arch Oral Biol 2025 Jan;169:106122. Epub 2024 Oct 29 doi: 10.1016/j.archoralbio.2024.106122. PMID: 39486274
Toxoplasma gondii UBL-UBA shuttle proteins regulate several important cellular processes.
Zhang H, Xue Y, Yang X, Liu J, Liu Q
FASEB J 2021 Dec;35(12):e21898. doi: 10.1096/fj.202100662RR. PMID: 34727385
Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.
Matsuoka M, Inoue T, Shinjo T, Miiji A, Tamashiro M, Oba K, Arima H, Arasaki O
Hypertens Res 2020 Aug;43(8):817-823. Epub 2020 Mar 17 doi: 10.1038/s41440-020-0427-z. PMID: 32203449
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.
Wang CY, Xu Y, Wang X, Guo C, Wang T, Wang ZY
Antioxid Redox Signal 2019 Apr 10;30(11):1411-1431. Epub 2018 Apr 25 doi: 10.1089/ars.2017.7440. PMID: 29634349
Mucus clearance and lung function in cystic fibrosis with hypertonic saline.
Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC
N Engl J Med 2006 Jan 19;354(3):241-50. doi: 10.1056/NEJMoa043891. PMID: 16421365

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