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Stage 4 Neuroblastoma

MedGen UID:
78866
Concept ID:
C0278694
Neoplastic Process
Synonyms: Disseminated Neuroblastoma; Metastatic neuroblastoma; Stage IV Neuroblastoma
SNOMED CT: Metastatic neuroblastoma (704152002)

Definition

Any primary tumor with dissemination to distant lymph nodes, bone, bone marrow, liver, skin, and/or other organs, except as defined for stage 4S. (cancer.gov) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Berthold F, Hero B
Drugs 2000 Jun;59(6):1261-77. doi: 10.2165/00003495-200059060-00006. PMID: 10882162
Klingebiel T, Bader P, Bares R, Beck J, Hero B, Jürgens H, Lang P, Niethammer D, Rath B, Handgretinger R
Eur J Cancer 1998 Aug;34(9):1398-402. doi: 10.1016/s0959-8049(98)00130-0. PMID: 9849423

Recent clinical studies

Etiology

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Zhu J, Wang J, Zhen ZJ, Lu SY, Zhang F, Sun FF, Li PF, Huang JT, Cai RQ, Sun XF
Chin J Cancer 2015 Sep 14;34(11):531-7. doi: 10.1186/s40880-015-0038-2. PMID: 26370236Free PMC Article
Valteau-Couanet D, Benhamou E, Vassal G, Stambouli F, Lapierre V, Couanet D, Lumbroso J, Hartmann O
Bone Marrow Transplant 2000 May;25(9):937-42. doi: 10.1038/sj.bmt.1702376. PMID: 10800060

Diagnosis

Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Zhu J, Wang J, Zhen ZJ, Lu SY, Zhang F, Sun FF, Li PF, Huang JT, Cai RQ, Sun XF
Chin J Cancer 2015 Sep 14;34(11):531-7. doi: 10.1186/s40880-015-0038-2. PMID: 26370236Free PMC Article
Kounami S, Nakayama K, Yoshiyama M, Rikoh M, Watanabe T, Takifuji K, Yoshikawa N
Pediatr Hematol Oncol 2012 Feb;29(1):99-103. doi: 10.3109/08880018.2011.643529. PMID: 22304016
Trobaugh-Lotrario AD, Greffe B, Deterding R, Deutsch G, Quinones R
J Pediatr Hematol Oncol 2003 May;25(5):405-9. doi: 10.1097/00043426-200305000-00011. PMID: 12759629

Therapy

Garaventa A, Poetschger U, Valteau-Couanet D, Luksch R, Castel V, Elliott M, Ash S, Chan GCF, Laureys G, Beck-Popovic M, Vettenranta K, Balwierz W, Schroeder H, Owens C, Cesen M, Papadakis V, Trahair T, Schleiermacher G, Ambros P, Sorrentino S, Pearson ADJ, Ladenstein RL
J Clin Oncol 2021 Aug 10;39(23):2552-2563. Epub 2021 Jun 21 doi: 10.1200/JCO.20.03144. PMID: 34152804
Laino ME, Monti S, Klimstra DS, Tang LH, Mannelli L
J Pediatr Hematol Oncol 2019 Mar;41(2):138-139. doi: 10.1097/MPH.0000000000001362. PMID: 30499907Free PMC Article
Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN
Lancet Oncol 2018 Dec;19(12):1617-1629. Epub 2018 Nov 12 doi: 10.1016/S1470-2045(18)30578-3. PMID: 30442501
Modak S, Asante-Korang A, Steinherz LJ, Grana N
J Pediatr Hematol Oncol 2015 Aug;37(6):e381-3. doi: 10.1097/MPH.0000000000000364. PMID: 26181424
Trobaugh-Lotrario AD, Greffe B, Deterding R, Deutsch G, Quinones R
J Pediatr Hematol Oncol 2003 May;25(5):405-9. doi: 10.1097/00043426-200305000-00011. PMID: 12759629

Prognosis

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R
Eur J Cancer 2021 Feb;144:1-8. Epub 2020 Dec 11 doi: 10.1016/j.ejca.2020.10.020. PMID: 33316634
Suzuki M, Kushner BH, Kramer K, Basu EM, Roberts SS, Hammond WJ, LaQuaglia MP, Wolden SL, Cheung NV, Modak S
Int J Cancer 2018 Sep 1;143(5):1249-1258. Epub 2018 Apr 6 doi: 10.1002/ijc.31399. PMID: 29574715Free PMC Article
Zhu J, Wang J, Zhen ZJ, Lu SY, Zhang F, Sun FF, Li PF, Huang JT, Cai RQ, Sun XF
Chin J Cancer 2015 Sep 14;34(11):531-7. doi: 10.1186/s40880-015-0038-2. PMID: 26370236Free PMC Article
Modak S, Asante-Korang A, Steinherz LJ, Grana N
J Pediatr Hematol Oncol 2015 Aug;37(6):e381-3. doi: 10.1097/MPH.0000000000000364. PMID: 26181424
Kounami S, Nakayama K, Yoshiyama M, Rikoh M, Watanabe T, Takifuji K, Yoshikawa N
Pediatr Hematol Oncol 2012 Feb;29(1):99-103. doi: 10.3109/08880018.2011.643529. PMID: 22304016

Clinical prediction guides

Lu X, Li C, Wang S, Yin Y, Fu H, Wang H, Cheng W, Chen S
Eur Radiol 2024 Nov;34(11):7125-7135. Epub 2024 May 17 doi: 10.1007/s00330-024-10781-w. PMID: 38758254
Edwards CM, Elefant D, Isakoff MS, Gaffar MA
J AAPOS 2024 Apr;28(2):103852. Epub 2024 Feb 17 doi: 10.1016/j.jaapos.2024.103852. PMID: 38368925
Garaventa A, Poetschger U, Valteau-Couanet D, Luksch R, Castel V, Elliott M, Ash S, Chan GCF, Laureys G, Beck-Popovic M, Vettenranta K, Balwierz W, Schroeder H, Owens C, Cesen M, Papadakis V, Trahair T, Schleiermacher G, Ambros P, Sorrentino S, Pearson ADJ, Ladenstein RL
J Clin Oncol 2021 Aug 10;39(23):2552-2563. Epub 2021 Jun 21 doi: 10.1200/JCO.20.03144. PMID: 34152804
Banelli B, Merlo DF, Allemanni G, Forlani A, Romani M
PLoS One 2013;8(5):e63253. Epub 2013 May 22 doi: 10.1371/journal.pone.0063253. PMID: 23717404Free PMC Article
Cheung IY, Feng Y, Cheung NK
Pediatr Blood Cancer 2013 Jul;60(7):E32-4. Epub 2013 Jan 17 doi: 10.1002/pbc.24469. PMID: 23335404

Recent systematic reviews

Mullassery D, Farrelly P, Losty PD
Pediatr Hematol Oncol 2014 Nov;31(8):703-16. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.947009. PMID: 25247398

Supplemental Content

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