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Neurological symptom

MedGen UID:
66714
•Concept ID:
C0235031
•
Sign or Symptom
Synonyms: Neurologic Symptom; Neurologic Symptoms; Symptom, Neurologic; Symptoms, Neurologic
SNOMED CT: Neurological symptom (308921004); Symptom of nervous system (308921004)

Definition

A term that refers to the clinical manifestations resulting from pathologic processes that affect the central and peripheral nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurological symptom

Professional guidelines

PubMed

Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Consensus clinical management guidelines for Niemann-Pick disease type C.
Geberhiwot T, Moro A, Dardis A, Ramaswami U, Sirrs S, Marfa MP, Vanier MT, Walterfang M, Bolton S, Dawson C, Héron B, Stampfer M, Imrie J, Hendriksz C, Gissen P, Crushell E, Coll MJ, Nadjar Y, Klünemann H, Mengel E, Hrebicek M, Jones SA, Ory D, Bembi B, Patterson M; International Niemann-Pick Disease Registry (INPDR)
Orphanet J Rare Dis 2018 Apr 6;13(1):50. doi: 10.1186/s13023-018-0785-7. PMID: 29625568Free PMC Article

Recent clinical studies

Etiology

Functional Neurological Disorder in Pediatrics: Diagnostic Considerations.
Moulton H, DerMarderosian D, Chapman HA
R I Med J (2013) 2024 Nov 1;107(11):10-13. PMID: 39467190
Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures.
Tolchin B, Dworetzky BA, Baslet G
Epilepsia 2018 Jan;59(1):e18-e22. Epub 2017 Dec 7 doi: 10.1111/epi.13969. PMID: 29218816
The numb chin in breast cancer.
Horton J, Means ED, Cunningham TJ, Olson KB
J Neurol Neurosurg Psychiatry 1973 Apr;36(2):211-6. doi: 10.1136/jnnp.36.2.211. PMID: 4708456Free PMC Article

Diagnosis

Headache in Behçet's Disease.
Vinokur M, Burkett JG
Curr Pain Headache Rep 2020 Jul 15;24(9):50. doi: 10.1007/s11916-020-00882-8. PMID: 32671593
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Conversion, Factitious Disorder and Malingering: A Distinct Pattern or a Continuum?
Galli S, Tatu L, Bogousslavsky J, Aybek S
Front Neurol Neurosci 2018;42:72-80. Epub 2017 Nov 17 doi: 10.1159/000475699. PMID: 29151092
Psychogenic non-epileptic seizures in the older adult.
Yates E
J Psychosoc Nurs Ment Health Serv 2014 May;52(5):17-20. doi: 10.3928/02793695-20140423-01. PMID: 24815758
Dissociative disorders in DSM-5.
Spiegel D, Lewis-Fernández R, Lanius R, Vermetten E, Simeon D, Friedman M
Annu Rev Clin Psychol 2013;9:299-326. Epub 2013 Feb 1 doi: 10.1146/annurev-clinpsy-050212-185531. PMID: 23394228

Therapy

Cavernous Sinus Swelling and Abducens Nerve Paresis Due to Intracranial Hypotension.
Kobayashi Y, Kamijima S, Okumura G, Morizumi T, Nagamatsu K, Shimizu Y, Sasaki T, Sato A
Intern Med 2022 Oct 15;61(20):3111-3113. Epub 2022 Mar 26 doi: 10.2169/internalmedicine.8488-21. PMID: 35342130Free PMC Article
Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
New and potential strategies for the treatment of PMM2-CDG.
Gámez A, Serrano M, Gallego D, Vilas A, Pérez B
Biochim Biophys Acta Gen Subj 2020 Nov;1864(11):129686. Epub 2020 Jul 23 doi: 10.1016/j.bbagen.2020.129686. PMID: 32712172
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article

Prognosis

Functional Neurological Disorder in Pediatrics: Diagnostic Considerations.
Moulton H, DerMarderosian D, Chapman HA
R I Med J (2013) 2024 Nov 1;107(11):10-13. PMID: 39467190
CNS lymphoma masquerading as stroke: Cases report and literature review.
Liang X, Wang C, Liu Y
J Cell Mol Med 2023 Dec;27(23):3939-3947. Epub 2023 Nov 23 doi: 10.1111/jcmm.17995. PMID: 37997520Free PMC Article
Bridging the gap between patient-specific and patient-independent seizure prediction via knowledge distillation.
Wu D, Yang J, Sawan M
J Neural Eng 2022 Jun 10;19(3) doi: 10.1088/1741-2552/ac73b3. PMID: 35617933
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Atlantoaxial facet locking: treatment by facet manipulation and fixation. Experience in 14 cases.
Goel A, Shah A
J Neurosurg Spine 2011 Jan;14(1):3-9. Epub 2010 Dec 17 doi: 10.3171/2010.9.SPINE1010. PMID: 21166490

Clinical prediction guides

Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures.
Tolchin B, Dworetzky BA, Baslet G
Epilepsia 2018 Jan;59(1):e18-e22. Epub 2017 Dec 7 doi: 10.1111/epi.13969. PMID: 29218816
The numb chin in breast cancer.
Horton J, Means ED, Cunningham TJ, Olson KB
J Neurol Neurosurg Psychiatry 1973 Apr;36(2):211-6. doi: 10.1136/jnnp.36.2.211. PMID: 4708456Free PMC Article

Recent systematic reviews

Multi-organ clinical manifestations of Mpox: an umbrella review of systematic reviews.
Satapathy P, Khatib MN, Gaidhane S, Zahiruddin QS, Alrasheed HA, Al-Subaie MF, Al Kaabi NA, Garout M, Alfaresi M, Sulaiman T, Rabaan AA, Krsak M, Henao-Martinez AF, Franco-Paredes C, Serhan HA, Sah R
BMC Infect Dis 2024 Sep 17;24(1):992. doi: 10.1186/s12879-024-09884-y. PMID: 39289659Free PMC Article
Clinical characteristics, diagnosis, and treatment of central nervous system sporotrichosis: Systematic review and meta-analysis.
de Oliveira VF, Petrucci JF, Taborda M, Brener PZ, Kremer PGBB, Randi BA, Magri ASGK, Magri MMC, Levin AS, Silva GD
Mycoses 2024 Feb;67(2):e13697. doi: 10.1111/myc.13697. PMID: 38374494
Structural neuroimaging of somatoform disorders: A systematic review.
Rossetti MG, Delvecchio G, Calati R, Perlini C, Bellani M, Brambilla P
Neurosci Biobehav Rev 2021 Mar;122:66-78. Epub 2020 Dec 20 doi: 10.1016/j.neubiorev.2020.12.017. PMID: 33359097
Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Collantes MEV, Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG
Can J Neurol Sci 2021 Jan;48(1):66-76. Epub 2020 Jul 15 doi: 10.1017/cjn.2020.146. PMID: 32665054Free PMC Article
Risk factors for the onset and progression of Huntington disease.
Chao TK, Hu J, Pringsheim T
Neurotoxicology 2017 Jul;61:79-99. Epub 2017 Jan 20 doi: 10.1016/j.neuro.2017.01.005. PMID: 28111121

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