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Supraventricular tachycardia

MedGen UID:
52635
Concept ID:
C0039240
Disease or Syndrome
Synonyms: Supraventricular Tachycardia; Supraventricular Tachycardias; Tachycardia, Supraventricular; Tachycardias, Supraventricular
SNOMED CT: Supraventricular tachycardia (6456007); SVT - Supraventricular tachycardia (6456007)
 
HPO: HP:0004755

Definition

Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles. [from HPO]

Term Hierarchy

Conditions with this feature

Dilated cardiomyopathy 1E
MedGen UID:
331341
Concept ID:
C1832680
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the SCN5A gene.
Hypertrophic cardiomyopathy 10
MedGen UID:
331754
Concept ID:
C1834460
Disease or Syndrome
Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the MYL2 gene.
Scalp-ear-nipple syndrome
MedGen UID:
357183
Concept ID:
C1867020
Disease or Syndrome
Scalp-ear-nipple syndrome is characterized by aplasia cutis congenita of the scalp, breast anomalies that range from hypothelia or athelia to amastia, and minor anomalies of the external ears. Less frequent clinical characteristics include nail dystrophy, dental anomalies, cutaneous syndactyly of the digits, and renal malformations. Penetrance appears to be high, although there is substantial variable expressivity within families (Marneros et al., 2013).
Dilated cardiomyopathy 1AA
MedGen UID:
393713
Concept ID:
C2677338
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the ACTN2 gene.
Ogden syndrome
MedGen UID:
477078
Concept ID:
C3275447
Disease or Syndrome
Ogden syndrome (OGDNS) is an X-linked neurodevelopmental disorder characterized by postnatal growth failure, severely delayed psychomotor development, variable dysmorphic features, and hypotonia. Many patients also have cardiac malformations or arrhythmias (summary by Popp et al., 2015).
Mitochondrial DNA depletion syndrome 13
MedGen UID:
815922
Concept ID:
C3809592
Disease or Syndrome
FBXL4-related encephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome is a multi-system disorder characterized primarily by congenital or early-onset lactic acidosis and growth failure, feeding difficulty, hypotonia, and developmental delay. Other neurologic manifestations can include seizures, movement disorders, ataxia, autonomic dysfunction, and stroke-like episodes. All affected individuals alive at the time they were reported (median age: 3.5 years) demonstrated significant developmental delay. Other findings can involve the heart (hypertrophic cardiomyopathy, congenital heart malformations, arrhythmias), liver (mildly elevated transaminases), eyes (cataract, strabismus, nystagmus, optic atrophy), hearing (sensorineural hearing loss), and bone marrow (neutropenia, lymphopenia). Survival varies; the median age of reported deaths was two years (range 2 days – 75 months), although surviving individuals as old as 36 years have been reported. To date FBXL4-related mtDNA depletion syndrome has been reported in 50 individuals.
Atrial fibrillation, familial, 15
MedGen UID:
862706
Concept ID:
C4014269
Disease or Syndrome
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function. It is the most common sustained cardiac rhythm disturbance, and its prevalence increases as the population ages. An estimated 70,000 strokes each year are caused by atrial fibrillation (summary by Oberti et al., 2004). For a discussion of genetic heterogeneity of atrial fibrillation, see 608583.
Myopathy with abnormal lipid metabolism
MedGen UID:
934789
Concept ID:
C4310822
Disease or Syndrome
Lipid storage myopathy due to FLAD1 deficiency is an autosomal recessive inborn error of metabolism that includes variable mitochondrial dysfunction. The phenotype is extremely heterogeneous: some patients have a severe disorder with onset in infancy and cardiac and respiratory insufficiency resulting in early death, whereas others have a milder course with onset of muscle weakness in adulthood. Some patients show significant improvement with riboflavin treatment (summary by Olsen et al., 2016).
Cardiomyopathy, dilated, 2I
MedGen UID:
1841321
Concept ID:
C5830685
Disease or Syndrome
Dilated cardiomyopathy-2I (CMD2I) is characterized by early-onset severe congestive heart failure. Some patients experience supraventricular tachycardia. Structural heart defects and nemaline bodies in cardiac and skeletal muscle have been observed (Aspit et al., 2019; Cheema et al., 2020; Gurunathan et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of dilated cardiomyopathy, see 115200.

Professional guidelines

PubMed

Peng G, Zei PC
JAMA 2024 Feb 20;331(7):601-610. doi: 10.1001/jama.2024.0076. PMID: 38497695
Kotadia ID, Williams SE, O'Neill M
Clin Med (Lond) 2020 Jan;20(1):43-47. doi: 10.7861/clinmed.cme.20.1.3. PMID: 31941731Free PMC Article
Link MS
N Engl J Med 2012 Oct 11;367(15):1438-48. doi: 10.1056/NEJMcp1111259. PMID: 23050527

Recent clinical studies

Etiology

Aljohani OA, Herrick NL, Borquez AA, Shepard S, Wieler ME, Perry JC, Williams MR
Pediatr Cardiol 2021 Mar;42(3):716-720. Epub 2021 Jan 8 doi: 10.1007/s00246-020-02534-5. PMID: 33416921
Kotadia ID, Williams SE, O'Neill M
Clin Med (Lond) 2020 Jan;20(1):43-47. doi: 10.7861/clinmed.cme.20.1.3. PMID: 31941731Free PMC Article
Mahtani AU, Nair DG
Med Clin North Am 2019 Sep;103(5):863-879. doi: 10.1016/j.mcna.2019.05.007. PMID: 31378331
Medi C, Kalman JM, Freedman SB
Med J Aust 2009 Mar 2;190(5):255-60. doi: 10.5694/j.1326-5377.2009.tb02388.x. PMID: 19296791
Rahimtoola SH
Curr Probl Cardiol 2008 Sep;33(9):463. doi: 10.1016/j.cpcardiol.2008.06.001. PMID: 18707989

Diagnosis

Morady F
Heart Rhythm 2021 Apr;18(4):651-652. doi: 10.1016/j.hrthm.2020.11.010. PMID: 33795072
Kotadia ID, Williams SE, O'Neill M
Clin Med (Lond) 2020 Jan;20(1):43-47. doi: 10.7861/clinmed.cme.20.1.3. PMID: 31941731Free PMC Article
Mahtani AU, Nair DG
Med Clin North Am 2019 Sep;103(5):863-879. doi: 10.1016/j.mcna.2019.05.007. PMID: 31378331
Link MS
N Engl J Med 2012 Oct 11;367(15):1438-48. doi: 10.1056/NEJMcp1111259. PMID: 23050527
Veenhuyzen GD, Quinn FR, Wilton SB, Clegg R, Mitchell LB
Pacing Clin Electrophysiol 2011 Jun;34(6):767-82. Epub 2011 Mar 25 doi: 10.1111/j.1540-8159.2011.03076.x. PMID: 21438892

Therapy

Abbasi E, Vijayashankar SS, Goldman RD
Can Fam Physician 2023 Dec;69(12):839-841. doi: 10.46747/cfp.6912839. PMID: 38092445Free PMC Article
Mahtani AU, Nair DG
Med Clin North Am 2019 Sep;103(5):863-879. doi: 10.1016/j.mcna.2019.05.007. PMID: 31378331
Al-Khatib SM, Page RL
JAMA Cardiol 2017 Mar 1;2(3):332-333. doi: 10.1001/jamacardio.2016.5085. PMID: 28030653
Link MS
N Engl J Med 2012 Oct 11;367(15):1438-48. doi: 10.1056/NEJMcp1111259. PMID: 23050527
Delacrétaz E
N Engl J Med 2006 Mar 9;354(10):1039-51. doi: 10.1056/NEJMcp051145. PMID: 16525141

Prognosis

Kim EJ, Hoffmann TJ, Nah G, Vittinghoff E, Delling F, Marcus GM
JAMA Intern Med 2021 Sep 1;181(9):1185-1193. doi: 10.1001/jamainternmed.2021.3616. PMID: 34279564Free PMC Article
Sorgente A, Cappato R
Herzschrittmacherther Elektrophysiol 2019 Dec;30(4):363-370. Epub 2019 Nov 21 doi: 10.1007/s00399-019-00652-z. PMID: 31754784
Chiengthong K, Lertjitbanjong P, Thongprayoon C, Bathini T, Sharma K, Prasitlumkum N, Mao MA, Cheungpasitporn W, Chokesuwattanaskul R
Eur J Haematol 2019 Dec;103(6):564-572. Epub 2019 Oct 6 doi: 10.1111/ejh.13322. PMID: 31478231
Walsh EP
Card Electrophysiol Rev 2002 Dec;6(4):422-30. doi: 10.1023/a:1021192526642. PMID: 12438823
Perry JC
Pacing Clin Electrophysiol 1997 Aug;20(8 Pt 2):2061-4. doi: 10.1111/j.1540-8159.1997.tb03628.x. PMID: 9272509

Clinical prediction guides

Luani B, Braun-Dullaeus RC
Int J Cardiovasc Imaging 2025 Mar;41(3):397-407. Epub 2024 Nov 11 doi: 10.1007/s10554-024-03275-9. PMID: 39527380
Hoevelmann J, Viljoen C, Chin A
Cardiovasc J Afr 2018 May/Jun;29(3):195-198. PMID: 30067274Free PMC Article
Lau YR, Kay GN
Circulation 2018 May 8;137(19):2076-2079. doi: 10.1161/CIRCULATIONAHA.118.034773. PMID: 29735593
Noheria A
Circ Arrhythm Electrophysiol 2018 Apr;11(4):e006444. doi: 10.1161/CIRCEP.118.006444. PMID: 29632020
Pollet M, Saeed M
Tex Heart Inst J 2016 Dec;43(6):507-508. Epub 2016 Dec 1 doi: 10.14503/THIJ-16-6088. PMID: 28100969Free PMC Article

Recent systematic reviews

Feng X, Liu J
BMC Cardiovasc Disord 2025 Mar 7;25(1):158. doi: 10.1186/s12872-025-04595-x. PMID: 40055614Free PMC Article
Miyawaki IA, Gomes C, Caporal S Moreira V, R Marques I, A F de Souza I, H A Silva C, Riceto Loyola Júnior JE, Huh K, McDowell M, Padrao EMH, Tichauer MB, Gibson CM
Am J Cardiovasc Drugs 2023 Jul;23(4):341-353. Epub 2023 May 10 doi: 10.1007/s40256-023-00581-w. PMID: 37162718
Kumari S, Pal B, Sahu SK, Prabhakar PK, Tewari D
Int J Legal Med 2023 Jul;137(4):1023-1037. Epub 2023 Apr 17 doi: 10.1007/s00414-023-02996-1. PMID: 37062796
Yuyun MF, Bonny A, Ng GA, Sliwa K, Kengne AP, Chin A, Mocumbi AO, Ngantcha M, Ajijola OA, Bukhman G
Glob Heart 2020 May 8;15(1):37. doi: 10.5334/gh.808. PMID: 32923331Free PMC Article
Chiengthong K, Lertjitbanjong P, Thongprayoon C, Bathini T, Sharma K, Prasitlumkum N, Mao MA, Cheungpasitporn W, Chokesuwattanaskul R
Eur J Haematol 2019 Dec;103(6):564-572. Epub 2019 Oct 6 doi: 10.1111/ejh.13322. PMID: 31478231

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