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Celiac disease, susceptibility to, 6(CELIAC6)

MedGen UID:
369397
•Concept ID:
C1969030
•
Finding
Synonyms: Celiac disease 6; CELIAC6; GLUTEN-SENSITIVE ENTEROPATHY, SUSCEPTIBILITY TO, 6
 
Monarch Initiative: MONDO:0012702
OMIM®: 611598

Definition

Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). For additional information and a discussion of genetic heterogeneity of celiac disease, see 212750. For a discussion of autoimmunity, see 109100. [from OMIM]

Professional guidelines

PubMed

Interaction between Gut Microbiota and Celiac Disease: From Pathogenesis to Treatment.
Rossi RE, Dispinzieri G, Elvevi A, Massironi S
Cells 2023 Mar 7;12(6) doi: 10.3390/cells12060823. PMID: 36980164Free PMC Article
Iron Deficiency in Women's Health: New Insights into Diagnosis and Treatment.
Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Advances in diagnosis and management of celiac disease.
Kelly CP, Bai JC, Liu E, Leffler DA
Gastroenterology 2015 May;148(6):1175-86. Epub 2015 Feb 3 doi: 10.1053/j.gastro.2015.01.044. PMID: 25662623Free PMC Article

Recent clinical studies

Etiology

Coeliac Disease High-Risk Human Leukocyte Antigen Alleles in a South African Type One Diabetic Population.
Gandini A, Wyk NV, Maayer T, Gededzha MP, Mayne E
Clin Lab 2023 Aug 1;69(8) doi: 10.7754/Clin.Lab.2023.220819. PMID: 37560854
Is the evidence of breast feeding protection against coeliac disease real?
Girbovan A, Sur G, Samasca G, Lupan I
Allergol Immunopathol (Madr) 2017 Nov-Dec;45(6):616-618. Epub 2017 Apr 12 doi: 10.1016/j.aller.2017.01.005. PMID: 28410871
Gluten in infants and celiac disease risk.
Andrén Aronsson C, Kurppa K, Agardh D
Expert Rev Gastroenterol Hepatol 2016 Jun;10(6):669-70. Epub 2016 Apr 8 doi: 10.1586/17474124.2016.1169922. PMID: 27027529
Celiac disease.
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Celiac disease.
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Diagnosis

Iron Deficiency in Women's Health: New Insights into Diagnosis and Treatment.
Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Celiac Disease in Children.
Jimenez J, Loveridge-Lenza B, Horvath K
Pediatr Clin North Am 2021 Dec;68(6):1205-1219. doi: 10.1016/j.pcl.2021.07.007. PMID: 34736585
Non-Celiac Gluten Sensitivity: An Update.
Cárdenas-Torres FI, Cabrera-Chávez F, Figueroa-Salcido OG, Ontiveros N
Medicina (Kaunas) 2021 May 24;57(6) doi: 10.3390/medicina57060526. PMID: 34073654Free PMC Article
Celiac Disease: Fallacies and Facts.
Silvester JA, Therrien A, Kelly CP
Am J Gastroenterol 2021 Jun 1;116(6):1148-1155. doi: 10.14309/ajg.0000000000001218. PMID: 33767109Free PMC Article
Celiac disease.
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Therapy

Iron Deficiency in Women's Health: New Insights into Diagnosis and Treatment.
Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Non-Celiac Gluten Sensitivity: An Update.
Cárdenas-Torres FI, Cabrera-Chávez F, Figueroa-Salcido OG, Ontiveros N
Medicina (Kaunas) 2021 May 24;57(6) doi: 10.3390/medicina57060526. PMID: 34073654Free PMC Article
Celiac Disease: Fallacies and Facts.
Silvester JA, Therrien A, Kelly CP
Am J Gastroenterol 2021 Jun 1;116(6):1148-1155. doi: 10.14309/ajg.0000000000001218. PMID: 33767109Free PMC Article
Celiac disease.
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Celiac disease.
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Prognosis

Interplay between Type 1 Diabetes Mellitus and Celiac Disease: Implications in Treatment.
Kaur N, Bhadada SK, Minz RW, Dayal D, Kochhar R
Dig Dis 2018;36(6):399-408. Epub 2018 Jul 25 doi: 10.1159/000488670. PMID: 30045024
Recent advances in pediatric celiac disease.
Lee GJ, Kao JY
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):583-592. Epub 2017 Mar 28 doi: 10.1080/17474124.2017.1309288. PMID: 28317399
Advances in diagnosis and management of celiac disease.
Kelly CP, Bai JC, Liu E, Leffler DA
Gastroenterology 2015 May;148(6):1175-86. Epub 2015 Feb 3 doi: 10.1053/j.gastro.2015.01.044. PMID: 25662623Free PMC Article
Celiac disease.
Guandalini S, Setty M
Curr Opin Gastroenterol 2008 Nov;24(6):707-12. doi: 10.1097/MOG.0b013e32830f4527. PMID: 19122520
Celiac disease.
Catassi C, Fasano A
Curr Opin Gastroenterol 2008 Nov;24(6):687-91. doi: 10.1097/MOG.0b013e32830edc1e. PMID: 19122516

Clinical prediction guides

The causal relationship between sarcoidosis and autoimmune diseases: a bidirectional Mendelian randomization study in FinnGen.
Sun D, Ma R, Wang J, Wang Y, Ye Q
Front Immunol 2024;15:1325127. Epub 2024 Apr 22 doi: 10.3389/fimmu.2024.1325127. PMID: 38711527Free PMC Article
Genotypes predisposing for celiac disease and autoimmune diabetes and risk of infections in early childhood.
Størdal K, Tapia G, Lund-Blix NA, Stene LC
J Pediatr Gastroenterol Nutr 2024 Feb;78(2):295-303. Epub 2023 Dec 11 doi: 10.1002/jpn3.12078. PMID: 38374560
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene.
Hernangomez-Laderas A, Cilleros-Portet A, Martínez Velasco S, Marí S, Legarda M, González-García BP, Tutau C, García-Santisteban I, Irastorza I, Fernandez-Jimenez N, Bilbao JR
Biol Sex Differ 2023 Dec 11;14(1):86. doi: 10.1186/s13293-023-00572-1. PMID: 38072919Free PMC Article
Recent advances in pediatric celiac disease.
Lee GJ, Kao JY
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):583-592. Epub 2017 Mar 28 doi: 10.1080/17474124.2017.1309288. PMID: 28317399
Advances in diagnosis and management of celiac disease.
Kelly CP, Bai JC, Liu E, Leffler DA
Gastroenterology 2015 May;148(6):1175-86. Epub 2015 Feb 3 doi: 10.1053/j.gastro.2015.01.044. PMID: 25662623Free PMC Article

Recent systematic reviews

Celiac disease: Hope for new treatments beyond a gluten-free diet.
D'heedene M, Vanuytsel T, Wauters L
Clin Nutr 2024 Jun;43(6):1240-1249. Epub 2024 Apr 15 doi: 10.1016/j.clnu.2024.04.014. PMID: 38648685
Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks.
Yang G, Zhang B, Huang W, Zhang N, Dong F, Jing L, Wang M, Liu Y, Guo C, Pan H, Wei X, Jing C
Expert Rev Gastroenterol Hepatol 2015;9(10):1327-38. Epub 2015 Aug 8 doi: 10.1586/17474124.2015.1075880. PMID: 26289103
Prevalence of celiac disease in latin america: a systematic review and meta-regression.
Parra-Medina R, Molano-Gonzalez N, Rojas-Villarraga A, Agmon-Levin N, Arango MT, Shoenfeld Y, Anaya JM
PLoS One 2015;10(5):e0124040. Epub 2015 May 5 doi: 10.1371/journal.pone.0124040. PMID: 25942408Free PMC Article

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