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Breast malignant eccrine spiradenoma

MedGen UID:
277329
•Concept ID:
C1334565
•
Neoplastic Process
Synonyms: breast malignant eccrine spiradenoma; breast malignant spiradenoma; Malignant Breast Eccrine Spiradenoma; malignant breast eccrine spiradenoma; Malignant Breast Spiradenoma; Malignant Eccrine Spiradenoma of Breast; malignant eccrine spiradenoma of breast; Malignant Eccrine Spiradenoma of the Breast; malignant eccrine spiradenoma of the breast; malignant spiradenoma of breast
 
Monarch Initiative: MONDO:0004420

Definition

A rare tumor characterized by malignant transformation of an eccrine spiradenoma of the breast. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast malignant eccrine spiradenoma

Recent clinical studies

Etiology

Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review.
Metovic J, Gallino C, Zanon E, Bussone R, Russo R, Vissio E, Annaratone L, Conti L, Papotti M, Cassoni P, Castellano I
Histol Histopathol 2019 Aug;34(8):909-915. Epub 2019 Feb 26 doi: 10.14670/HH-18-094. PMID: 30806477
Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up.
Rooper LM, Iding JS, Cuda JD, Ali SZ
Acta Cytol 2016;60(2):173-8. Epub 2016 Mar 25 doi: 10.1159/000445095. PMID: 27010690
Benign hidradenoma masquerading as ductal breast cancer-a rare case of false-positive recurrence in cancer follow-up.
Ives CL, Donnelly PK, Ryley N, Green R, Bliss P, Ellis I
Breast J 2013 Nov-Dec;19(6):670-1. Epub 2013 Sep 19 doi: 10.1111/tbj.12187. PMID: 24102904
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522
Fine-needle cytology of an eccrine spiradenoma of the breast: diagnosis made by a holistic approach.
Bosch MM, Boon ME
Diagn Cytopathol 1992;8(4):366-8. doi: 10.1002/dc.2840080412. PMID: 1322262

Diagnosis

Challenging diagnosis of male intraductal papilloma masquerading as eccrine hidradenoma in the breast: Case report.
Liu X, Du J, Zhao L
Medicine (Baltimore) 2024 Mar 29;103(13):e37607. doi: 10.1097/MD.0000000000037607. PMID: 38552084Free PMC Article
Association of HPV42 with digital papillary adenocarcinoma and the use of in situ hybridization for its distinction from acral hidradenoma and diagnosis at non-acral sites.
Vanderbilt C, Brenn T, Moy AP, Harloe G, Ariyan C, Athanasian E, Busam KJ
Mod Pathol 2022 Oct;35(10):1405-1410. Epub 2022 May 10 doi: 10.1038/s41379-022-01094-8. PMID: 35538210
Hidradenoma of the Breast: A Source of Diagnostic Confusion.
Vasconcelos I, Radke C, Tellechea Ó, Schoenegg W
Breast J 2015 Nov-Dec;21(6):681-2. Epub 2015 Sep 22 doi: 10.1111/tbj.12507. PMID: 26391316
Pseudoxanthoma elasticum-like change adjacent to a benign adnexal neoplasm: a histopathologic reaction pattern.
Aung PP, Mahalingam M
Am J Dermatopathol 2015 Feb;37(2):157-9. doi: 10.1097/DAD.0000000000000215. PMID: 25365498
An unusual tumor of the breast resembling eccrine spiradenoma.
DRAHEIM JH, NEUBECKER RD, SPRINZ H
Am J Clin Pathol 1959 Jun;31(6):511-6. doi: 10.1093/ajcp/31.6.511. PMID: 13661107

Therapy

Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy.
Plunkett TA, Hanby AM, Miles DW, Rubens RD
Ann Oncol 2001 Mar;12(3):411-4. doi: 10.1023/a:1011196615177. PMID: 11332156

Prognosis

Distant metastasis from morphologically low-grade spiradenocarcinoma: A report of two cases.
Lach K, Gharpuray-Pandit D, Franko A, Brenn T
J Cutan Pathol 2023 Jul;50(7):642-646. Epub 2023 Jan 25 doi: 10.1111/cup.14388. PMID: 36617528
Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population.
Matsumoto H, Takamatsu R, Abe N, Unesoko M, Zaha H, Ishii A, Nakada N, Nishihara H, Tan PH, Yoshimi N
Virchows Arch 2021 Aug;479(2):401-405. Epub 2020 Nov 5 doi: 10.1007/s00428-020-02958-7. PMID: 33150535
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations.
Konstantinova AM, Michal M, Kacerovska D, Spagnolo DV, Stewart CJ, Kutzner H, Zelger B, Plaza JA, Denisjuk N, Hejda V, Shelekhova K, Bisceglia M, Danis D, Zamecnik M, Kerl K, Guenova E, Kazakov DV
Am J Dermatopathol 2016 Aug;38(8):598-607. doi: 10.1097/DAD.0000000000000495. PMID: 26863059
Benign hidradenoma masquerading as ductal breast cancer-a rare case of false-positive recurrence in cancer follow-up.
Ives CL, Donnelly PK, Ryley N, Green R, Bliss P, Ellis I
Breast J 2013 Nov-Dec;19(6):670-1. Epub 2013 Sep 19 doi: 10.1111/tbj.12187. PMID: 24102904
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Clinical prediction guides

Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population.
Matsumoto H, Takamatsu R, Abe N, Unesoko M, Zaha H, Ishii A, Nakada N, Nishihara H, Tan PH, Yoshimi N
Virchows Arch 2021 Aug;479(2):401-405. Epub 2020 Nov 5 doi: 10.1007/s00428-020-02958-7. PMID: 33150535
Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies.
Tran TAN, Bridge JA, Deharvengt SJ, Green DC, Linos K
Int J Surg Pathol 2020 Jun;28(4):427-435. Epub 2019 Dec 9 doi: 10.1177/1066896919888579. PMID: 31813296
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology.
Lin XY, Zhang H, Tang N, Zhang XP, Zhang W, Wang EH, Han YC
Histopathology 2015 Apr;66(5):685-94. Epub 2015 Jan 22 doi: 10.1111/his.12536. PMID: 25431204
Pseudoxanthoma elasticum-like change adjacent to a benign adnexal neoplasm: a histopathologic reaction pattern.
Aung PP, Mahalingam M
Am J Dermatopathol 2015 Feb;37(2):157-9. doi: 10.1097/DAD.0000000000000215. PMID: 25365498
An unusual, recurring breast tumor with features of eccrine spiradenoma: a case report.
Panico L, D'Antonio A, Chiacchio R, Delrio P, Petrella G, Pettinato G
Am J Clin Pathol 1996 Nov;106(5):665-9. doi: 10.1093/ajcp/106.5.665. PMID: 8929479

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