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Hereditary Female Breast Carcinoma

MedGen UID:
272712
•Concept ID:
C1333986
•
Neoplastic Process
Synonym: Familial Female Breast Carcinoma

Definition

Breast carcinoma that has developed in female relatives of patients with history of breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary Female Breast Carcinoma

Professional guidelines

PubMed

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.
Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S, Giri V, Goggins M, Hagemann A, Hendrix A, Hutton ML, Karlan BY, Kassem N, Khan S, Khoury K, Kurian AW, Laronga C, Mak JS, Mansour J, McDonnell K, Menendez CS, Merajver SD, Norquist BS, Offit K, Rash D, Reiser G, Senter-Jamieson L, Shannon KM, Visvanathan K, Welborn J, Wick MJ, Wood M, Yurgelun MB, Dwyer MA, Darlow SD
J Natl Compr Canc Netw 2023 Oct;21(10):1000-1010. doi: 10.6004/jnccn.2023.0051. PMID: 37856201
Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831

Recent clinical studies

Etiology

Male Breast Cancer: a Review on Diagnosis, Treatment, and Survivorship.
Bhardwaj PV, Gupta S, Elyash A, Teplinsky E
Curr Oncol Rep 2024 Jan;26(1):34-45. Epub 2024 Jan 2 doi: 10.1007/s11912-023-01489-z. PMID: 38224426
Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.
Yoshimura A, Imoto I, Iwata H
Int J Mol Sci 2022 Jul 5;23(13) doi: 10.3390/ijms23137481. PMID: 35806485Free PMC Article
Young Women With Breast Cancer: Treatment, Care, and Nursing Implications.
Corey B, Smania MA, Spotts H, Andersen M
Clin J Oncol Nurs 2020 Apr 1;24(2):139-147. doi: 10.1188/20.CJON.139-147. PMID: 32196004
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article

Diagnosis

Male Breast Cancer: a Review on Diagnosis, Treatment, and Survivorship.
Bhardwaj PV, Gupta S, Elyash A, Teplinsky E
Curr Oncol Rep 2024 Jan;26(1):34-45. Epub 2024 Jan 2 doi: 10.1007/s11912-023-01489-z. PMID: 38224426
Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.
Ponti G, De Angelis C, Ponti R, Pongetti L, Losi L, Sticchi A, Tomasi A, Ozben T
Crit Rev Clin Lab Sci 2023 Dec;60(8):640-650. Epub 2023 Jul 16 doi: 10.1080/10408363.2023.2234488. PMID: 37455374
Hereditary Diffuse Gastric Cancer.
Decourtye-Espiard L, Guilford P
Gastroenterology 2023 Apr;164(5):719-735. Epub 2023 Feb 4 doi: 10.1053/j.gastro.2023.01.038. PMID: 36740198
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Health and Racial Disparity in Breast Cancer.
Yedjou CG, Sims JN, Miele L, Noubissi F, Lowe L, Fonseca DD, Alo RA, Payton M, Tchounwou PB
Adv Exp Med Biol 2019;1152:31-49. doi: 10.1007/978-3-030-20301-6_3. PMID: 31456178Free PMC Article

Therapy

PARP Inhibitors for Breast Cancer Treatment: A Review.
Morganti S, Marra A, De Angelis C, Toss A, Licata L, Giugliano F, Taurelli Salimbeni B, Berton Giachetti PPM, Esposito A, Giordano A, Bianchini G, Garber JE, Curigliano G, Lynce F, Criscitiello C
JAMA Oncol 2024 May 1;10(5):658-670. doi: 10.1001/jamaoncol.2023.7322. PMID: 38512229
Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study.
Lång K, Josefsson V, Larsson AM, Larsson S, Högberg C, Sartor H, Hofvind S, Andersson I, Rosso A
Lancet Oncol 2023 Aug;24(8):936-944. doi: 10.1016/S1470-2045(23)00298-X. PMID: 37541274
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer.
Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Breastfeeding and maternal and infant health outcomes in developed countries.
Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J
Evid Rep Technol Assess (Full Rep) 2007 Apr;(153):1-186. PMID: 17764214Free PMC Article

Prognosis

Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.
Ponti G, De Angelis C, Ponti R, Pongetti L, Losi L, Sticchi A, Tomasi A, Ozben T
Crit Rev Clin Lab Sci 2023 Dec;60(8):640-650. Epub 2023 Jul 16 doi: 10.1080/10408363.2023.2234488. PMID: 37455374
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Molecular Testing in Breast Cancer.
Litton JK, Burstein HJ, Turner NC
Am Soc Clin Oncol Educ Book 2019 Jan;39:e1-e7. Epub 2019 May 17 doi: 10.1200/EDBK_237715. PMID: 31099622
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article

Clinical prediction guides

PARP Inhibitors for Breast Cancer Treatment: A Review.
Morganti S, Marra A, De Angelis C, Toss A, Licata L, Giugliano F, Taurelli Salimbeni B, Berton Giachetti PPM, Esposito A, Giordano A, Bianchini G, Garber JE, Curigliano G, Lynce F, Criscitiello C
JAMA Oncol 2024 May 1;10(5):658-670. doi: 10.1001/jamaoncol.2023.7322. PMID: 38512229
Hereditary breast and ovarian cancer: from genes to molecular targeted therapies.
Ponti G, De Angelis C, Ponti R, Pongetti L, Losi L, Sticchi A, Tomasi A, Ozben T
Crit Rev Clin Lab Sci 2023 Dec;60(8):640-650. Epub 2023 Jul 16 doi: 10.1080/10408363.2023.2234488. PMID: 37455374
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article
Genetics of breast cancer: a topic in evolution.
Shiovitz S, Korde LA
Ann Oncol 2015 Jul;26(7):1291-9. Epub 2015 Jan 20 doi: 10.1093/annonc/mdv022. PMID: 25605744Free PMC Article

Recent systematic reviews

Germline Testing in Patients With Breast Cancer: ASCO-Society of Surgical Oncology Guideline.
Bedrosian I, Somerfield MR, Achatz MI, Boughey JC, Curigliano G, Friedman S, Kohlmann WK, Kurian AW, Laronga C, Lynce F, Norquist BS, Plichta JK, Rodriguez P, Shah PD, Tischkowitz M, Wood M, Yadav S, Yao K, Robson ME
J Clin Oncol 2024 Feb 10;42(5):584-604. Epub 2024 Jan 4 doi: 10.1200/JCO.23.02225. PMID: 38175972
Germline CDH1 variants in hereditary diffuse gastric cancer syndrome with focus on younger women.
Corso G, Comelli G, Veronesi P, Bianchi B, Petitto S, Polizzi A, Girardi A, Cioffi A, La Vecchia C, Bagnardi V, Magnoni F
J Cancer Res Clin Oncol 2023 Nov;149(17):16147-16155. Epub 2023 Aug 28 doi: 10.1007/s00432-023-05318-5. PMID: 37639007
BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828Free PMC Article
Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review.
Huber D, Seitz S, Kast K, Emons G, Ortmann O
J Cancer Res Clin Oncol 2021 Jul;147(7):2035-2045. Epub 2021 Apr 22 doi: 10.1007/s00432-021-03629-z. PMID: 33885953Free PMC Article
BRCA1 and BRCA2 Gene Mutations and Lung Cancer Sisk: A Meta-Analysis.
Lee YC, Lee YC, Li CY, Lee YL, Chen BL
Medicina (Kaunas) 2020 Apr 27;56(5) doi: 10.3390/medicina56050212. PMID: 32349445Free PMC Article

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