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Childhood kidney Wilms tumor

MedGen UID:
232073
•Concept ID:
C1333015
•
Neoplastic Process
Synonyms: Childhood Kidney Nephroblastoma; Childhood Kidney Wilms Tumor; childhood kidney Wilms tumor; Childhood Renal Wilms Tumor; childhood renal Wilms tumor; childhood renal Wilms tumour; Childhood Renal Wilms' Tumor; childhood renal Wilms' tumor; childhood renal Wilms' tumour; childhood Wilms tumor; childhood Wilms tumour
 
Monarch Initiative: MONDO:0024676

Definition

A Wilms tumor of the kidney which occurs in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood kidney Wilms tumor

Professional guidelines

PubMed

Leveraging Circulating Tumor DNA to Optimize the Initial Management of Childhood Renal Tumors.
Ortiz MV
J Clin Oncol 2022 Sep 10;40(26):3006-3010. Epub 2022 Jul 5 doi: 10.1200/JCO.22.00820. PMID: 35786967
Cardiomyopathy in Children: Classification and Diagnosis: A Scientific Statement From the American Heart Association.
Lipshultz SE, Law YM, Asante-Korang A, Austin ED, Dipchand AI, Everitt MD, Hsu DT, Lin KY, Price JF, Wilkinson JD, Colan SD
Circulation 2019 Jul 2;140(1):e9-e68. Epub 2019 May 28 doi: 10.1161/CIR.0000000000000682. PMID: 31132865
Management of Wilms Tumor: ICMR Consensus Document.
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S
Indian J Pediatr 2017 Jun;84(6):437-445. Epub 2017 Apr 3 doi: 10.1007/s12098-017-2305-5. PMID: 28367612

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Wilms Tumor (Nephroblastoma), 2023

Recent clinical studies

Etiology

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
From Wilms to kidney tumors: which ones require a biopsy?
Brisse HJ, de la Monneraye Y, Cardoen L, Schleiermacher G
Pediatr Radiol 2020 Jul;50(8):1049-1051. Epub 2020 Apr 5 doi: 10.1007/s00247-020-04660-x. PMID: 32248272
Wilms tumor.
Green DM, D'Angio GJ, Beckwith JB, Breslow NE, Grundy PE, Ritchey ML, Thomas PR
CA Cancer J Clin 1996 Jan-Feb;46(1):46-63. doi: 10.3322/canjclin.46.1.46. PMID: 8548525
Radiation-induced osteochondromas.
Libshitz HI, Cohen MA
Radiology 1982 Mar;142(3):643-7. doi: 10.1148/radiology.142.3.6278535. PMID: 6278535

Diagnosis

Wilms Tumor.
Saltzman AF, Cost NG, Romao RLP
Urol Clin North Am 2023 Aug;50(3):455-464. Epub 2023 May 18 doi: 10.1016/j.ucl.2023.04.008. PMID: 37385707
Abdominal Tumors: Wilms, Neuroblastoma, Rhabdomyosarcoma, and Hepatoblastoma.
Castle JT, Levy BE, Rodeberg DA
Surg Clin North Am 2022 Oct;102(5):715-737. Epub 2022 Sep 7 doi: 10.1016/j.suc.2022.07.006. PMID: 36209742
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nat Commun 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. PMID: 32161258Free PMC Article
Renal dysplasia.
Chen RY, Chang H
Arch Pathol Lab Med 2015 Apr;139(4):547-51. doi: 10.5858/arpa.2013-0660-RS. PMID: 25822765

Therapy

Clinical Care for People Who Survive Childhood Cancer: A Review.
Bhatia S, Tonorezos ES, Landier W
JAMA 2023 Sep 26;330(12):1175-1186. doi: 10.1001/jama.2023.16875. PMID: 37750876
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Kendsersky NM, Lindsay J, Kolb EA, Smith MA, Teicher BA, Erickson SW, Earley EJ, Mosse YP, Martinez D, Pogoriler J, Krytska K, Patel K, Groff D, Tsang M, Ghilu S, Wang Y, Seaman S, Feng Y, Croix BS, Gorlick R, Kurmasheva R, Houghton PJ, Maris JM
Clin Cancer Res 2021 May 15;27(10):2938-2946. Epub 2021 Feb 22 doi: 10.1158/1078-0432.CCR-20-4221. PMID: 33619171Free PMC Article
Fifteen-minute consultation: Assessment, surveillance and management of hemihypertrophy.
Mark C, Hart C, McCarthy A, Thompson A
Arch Dis Child Educ Pract Ed 2018 Jun;103(3):114-117. Epub 2017 Aug 26 doi: 10.1136/archdischild-2017-312645. PMID: 28844056
Genetic and hereditary aspects of childhood obesity.
Farooqi IS
Best Pract Res Clin Endocrinol Metab 2005 Sep;19(3):359-74. doi: 10.1016/j.beem.2005.04.004. PMID: 16150380
Radiation-induced osteochondromas.
Libshitz HI, Cohen MA
Radiology 1982 Mar;142(3):643-7. doi: 10.1148/radiology.142.3.6278535. PMID: 6278535

Prognosis

Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Wilms tumour.
Spreafico F, Fernandez CV, Brok J, Nakata K, Vujanic G, Geller JI, Gessler M, Maschietto M, Behjati S, Polanco A, Paintsil V, Luna-Fineman S, Pritchard-Jones K
Nat Rev Dis Primers 2021 Oct 14;7(1):75. doi: 10.1038/s41572-021-00308-8. PMID: 34650095
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Lung tumours in children.
McCahon E
Paediatr Respir Rev 2006 Sep;7(3):191-6. Epub 2006 Aug 4 doi: 10.1016/j.prrv.2006.05.002. PMID: 16938641
Wilms tumor.
Green DM, D'Angio GJ, Beckwith JB, Breslow NE, Grundy PE, Ritchey ML, Thomas PR
CA Cancer J Clin 1996 Jan-Feb;46(1):46-63. doi: 10.3322/canjclin.46.1.46. PMID: 8548525

Clinical prediction guides

Clinical Care for People Who Survive Childhood Cancer: A Review.
Bhatia S, Tonorezos ES, Landier W
JAMA 2023 Sep 26;330(12):1175-1186. doi: 10.1001/jama.2023.16875. PMID: 37750876
Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities.
Venkataramany AS, Schieffer KM, Lee K, Cottrell CE, Wang PY, Mardis ER, Cripe TP, Chandler DS
Ann Oncol 2022 Jun;33(6):578-592. Epub 2022 Mar 23 doi: 10.1016/j.annonc.2022.03.011. PMID: 35339647
Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1.
Potluri S, Assi SA, Chin PS, Coleman DJL, Pickin A, Moriya S, Seki N, Heidenreich O, Cockerill PN, Bonifer C
Cell Rep 2021 Apr 20;35(3):109010. doi: 10.1016/j.celrep.2021.109010. PMID: 33882316
The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models.
Kendsersky NM, Lindsay J, Kolb EA, Smith MA, Teicher BA, Erickson SW, Earley EJ, Mosse YP, Martinez D, Pogoriler J, Krytska K, Patel K, Groff D, Tsang M, Ghilu S, Wang Y, Seaman S, Feng Y, Croix BS, Gorlick R, Kurmasheva R, Houghton PJ, Maris JM
Clin Cancer Res 2021 May 15;27(10):2938-2946. Epub 2021 Feb 22 doi: 10.1158/1078-0432.CCR-20-4221. PMID: 33619171Free PMC Article
Wilms tumor genetics.
Huff V
Am J Med Genet 1998 Oct 2;79(4):260-7. doi: 10.1002/(sici)1096-8628(19981002)79:4<260::aid-ajmg6>3.0.co;2-q. PMID: 9781905

Recent systematic reviews

Association between birth weight and risk of nonneurological childhood cancers: a systematic review and meta-analysis.
Rashti R, Ghasemi F, Poorolajal J
Eur J Cancer Prev 2025 Jan 1;34(1):40-52. Epub 2024 May 20 doi: 10.1097/CEJ.0000000000000894. PMID: 38837193
Evidence-based surgical guidelines for treating children with Wilms tumor in low-resource settings.
Abdelhafeez AH, Reljic T, Kumar A, Banu T, Cox S, Davidoff AM, Elgendy A, Ghandour K, Gerstle JT, Karpelowsky J, Kaste SC, Kechiche N, Esiashvili N, Nasir A, Ngongola A, Marollano J, Moreno AA, Muzira A, Parkes J, Saldaña LJ, Shalkow J, Vujanić GM, Velasquez T, Lakhoo K, Mukkada S, Abib S
Pediatr Blood Cancer 2022 Dec;69(12):e29906. Epub 2022 Aug 5 doi: 10.1002/pbc.29906. PMID: 35929184
Maternal lifestyle characteristics and Wilms tumor risk in the offspring: A systematic review and meta-analysis.
Doganis D, Katsimpris A, Panagopoulou P, Bouka P, Bouka E, Moschovi M, Polychronopoulou S, Papakonstantinou E, Tragiannidis A, Katzilakis N, Dana H, Antoniadi K, Stefanaki K, Strantzia K, Dessypris N, Schüz J, Petridou ET
Cancer Epidemiol 2020 Aug;67:101769. Epub 2020 Jul 10 doi: 10.1016/j.canep.2020.101769. PMID: 32659726
Clinical features, treatment, and outcomes of bilateral Wilms' tumor: A systematic review and meta-analysis.
Han Q, Li K, Dong K, Xiao X, Yao W, Liu G
J Pediatr Surg 2018 Dec;53(12):2465-2469. Epub 2018 Sep 1 doi: 10.1016/j.jpedsurg.2018.08.022. PMID: 30274708
Biomarkers for Wilms Tumor: A Systematic Review.
Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC
J Urol 2016 Nov;196(5):1530-1535. Epub 2016 May 31 doi: 10.1016/j.juro.2016.05.100. PMID: 27259655Free PMC Article

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Wilms Tumor (Nephroblastoma), 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
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