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Lobular neoplasia

MedGen UID:
167824
•Concept ID:
C0861352
•
Neoplastic Process
Synonyms: Breast LN; Breast Lobular Neoplasia; LIN; LN; Lobular Intraepithelial Neoplasia; lobular intraepithelial neoplasia; Lobular Neoplasia; lobular neoplasia
 
Monarch Initiative: MONDO:0002486

Definition

A spectrum of non-invasive neoplastic lesions that arise from the terminal ductal lobular units of the breast. There is atypical small epithelial cell proliferation. Pagetoid involvement of the terminal ducts may or may not be present. In the minority of cases, there is a risk for subsequent development of invasive ductal or invasive lobular carcinoma. [from NCI]

Professional guidelines

PubMed

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas.
Calle C, Kuba MG, Brogi E
Breast J 2020 Jun;26(6):1148-1155. Epub 2020 Jun 4 doi: 10.1111/tbj.13857. PMID: 32500575
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Preneoplasia of the Breast and Molecular Landscape.
Alvarado-Cabrero I, Valencia-Cedillo R, Estevez-Castro R
Arch Med Res 2020 Nov;51(8):845-850. Epub 2020 Sep 21 doi: 10.1016/j.arcmed.2020.09.011. PMID: 32972772
Lobular neoplasia.
King TA, Reis-Filho JS
Surg Oncol Clin N Am 2014 Jul;23(3):487-503. Epub 2014 Apr 16 doi: 10.1016/j.soc.2014.03.002. PMID: 24882347

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR
Breast Cancer Res 2021 Jan 7;23(1):6. doi: 10.1186/s13058-020-01384-6. PMID: 33413533Free PMC Article
Core Needle Biopsy of the Breast: An Evaluation of Contemporary Data.
Calhoun BC
Surg Pathol Clin 2018 Mar;11(1):1-16. Epub 2017 Dec 6 doi: 10.1016/j.path.2017.09.001. PMID: 29413652

Therapy

Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956
Risk for Upgrade to Malignancy After Breast Core Needle Biopsy Diagnosis of Lobular Neoplasia: A Systematic Review and Meta-Analysis.
Shehata MN, Rahbar H, Flanagan MR, Kilgore MR, Lee CI, Ryser MD, Lowry KP
J Am Coll Radiol 2020 Oct;17(10):1207-1219. Epub 2020 Aug 27 doi: 10.1016/j.jacr.2020.07.036. PMID: 32861602
Evolving concepts in the management of lobular neoplasia.
Anderson BO, Calhoun KE, Rosen EL
J Natl Compr Canc Netw 2006 May;4(5):511-22. doi: 10.6004/jnccn.2006.0041. PMID: 16687097
Image-guided breast biopsy and management of high-risk lesions.
Berg WA
Radiol Clin North Am 2004 Sep;42(5):935-46, vii. doi: 10.1016/j.rcl.2004.04.002. PMID: 15337426
The clinical significance of minimal breast cancer: a pathologist's viewpoint.
Wirman JA
Crit Rev Oncol Hematol 1985;3(1):35-74. doi: 10.1016/s1040-8428(85)80039-1. PMID: 2990747

Prognosis

The lobular neoplasia enigma: management and prognosis in a long follow-up case series.
Metovic J, Abate SO, Borella F, Vissio E, Bertero L, Mariscotti G, Durando M, Senetta R, Ala A, Benedetto C, Sapino A, Cassoni P, Castellano I
World J Surg Oncol 2021 Mar 18;19(1):80. doi: 10.1186/s12957-021-02182-w. PMID: 33736652Free PMC Article
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR
Breast Cancer Res 2021 Jan 7;23(1):6. doi: 10.1186/s13058-020-01384-6. PMID: 33413533Free PMC Article
The role of magnetic resonance imaging in screening women at high risk of breast cancer.
Warner E
Top Magn Reson Imaging 2008 Jun;19(3):163-9. doi: 10.1097/RMR.0b013e31818bc994. PMID: 18941396
Flat epithelial atypia of the breast.
Lerwill MF
Arch Pathol Lab Med 2008 Apr;132(4):615-21. doi: 10.5858/2008-132-615-FEAOTB. PMID: 18384213
The evaluation of high risk and pre-invasive breast lesions and the decision process for follow up and surgical intervention.
Simmons RM, Osborne MP
Surg Oncol 1999 Aug;8(2):55-65. doi: 10.1016/s0960-7404(99)00030-4. PMID: 10732957

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Lobular neoplasia detected at MRI-guided biopsy: imaging findings and outcomes.
Chikarmane SA, Harrison BT, Giess CS, Pinkney DM, Gombos EC
Clin Imaging 2021 Oct;78:171-178. Epub 2021 Mar 31 doi: 10.1016/j.clinimag.2021.03.026. PMID: 33838434
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
The role of magnetic resonance imaging in screening women at high risk of breast cancer.
Warner E
Top Magn Reson Imaging 2008 Jun;19(3):163-9. doi: 10.1097/RMR.0b013e31818bc994. PMID: 18941396

Recent systematic reviews

Atypical ductal or lobular hyperplasia, lobular carcinoma in-situ, flat epithelial atypia, and future risk of developing breast cancer: Systematic review and meta-analysis.
Baker J, Noguchi N, Marinovich ML, Sprague BL, Salisbury E, Houssami N
Breast 2024 Dec;78:103807. Epub 2024 Sep 11 doi: 10.1016/j.breast.2024.103807. PMID: 39270543Free PMC Article
The positive predictive value of vacuum assisted biopsy (VAB) in predicting final histological diagnosis for breast lesions of uncertain malignancy (B3 lesions): A systematic review & meta-analysis.
Cullinane C, Byrne J, Kelly L, O Sullivan M, Antony Corrigan M, Paul Redmond H
Eur J Surg Oncol 2022 Jul;48(7):1464-1474. Epub 2022 Apr 15 doi: 10.1016/j.ejso.2022.04.005. PMID: 35491362
Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956
Risk for Upgrade to Malignancy After Breast Core Needle Biopsy Diagnosis of Lobular Neoplasia: A Systematic Review and Meta-Analysis.
Shehata MN, Rahbar H, Flanagan MR, Kilgore MR, Lee CI, Ryser MD, Lowry KP
J Am Coll Radiol 2020 Oct;17(10):1207-1219. Epub 2020 Aug 27 doi: 10.1016/j.jacr.2020.07.036. PMID: 32861602

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