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Decreased level of 1,5 anhydroglucitol in serum

MedGen UID:
1635089
Concept ID:
C4703616
Finding
Synonyms: Decreased level of 1,5-AG in serum; Decreased level of 1,5-anhydro-D-glucitol in serum; Decreased level of 1,5-anhydroglucitol in serum
 
HPO: HP:0410050

Definition

A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased level of 1,5 anhydroglucitol in serum

Conditions with this feature

Diabetes mellitus type 1
MedGen UID:
41522
Concept ID:
C0011854
Disease or Syndrome
Type 1 diabetes mellitus (T1D), also designated insulin-dependent diabetes mellitus (IDDM), is a disorder of glucose homeostasis characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of T1D have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classic phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Recent clinical studies

Etiology

Zhou Z, Yao Y, Sun Y, Wang X, Huang S, Hou J, Wang L, Wei F
Endocrine 2024 Aug;85(2):649-659. Epub 2024 Mar 6 doi: 10.1007/s12020-024-03732-4. PMID: 38448678
Migała M, Chałubińska-Fendler J, Zielińska M
Rev Diabet Stud 2022 Jun 30;18(2):68-75. doi: 10.1900/RDS.2022.18.68. PMID: 35831937Free PMC Article
Ying L, Ma X, Shen Y, Lu J, Lu W, Zhu W, Wang Y, Bao Y, Zhou J
J Diabetes Res 2020;2020:1243630. Epub 2020 Mar 20 doi: 10.1155/2020/1243630. PMID: 32280712Free PMC Article
Zekavat SM, Butkovich S, Young GJ, Nathan DM, Petrasek D
Physiol Rep 2017 Aug;5(16) doi: 10.14814/phy2.13375. PMID: 28821595Free PMC Article
Su H, Ma X, Yin J, Wang Y, He X, Bao Y, Zhou J, Jia W
Acta Diabetol 2017 May;54(5):463-470. Epub 2017 Feb 16 doi: 10.1007/s00592-017-0968-z. PMID: 28210869

Diagnosis

Xu H, Chen R, Hou X, Li N, Han Y, Ji S
Front Endocrinol (Lausanne) 2024;15:1471577. Epub 2024 Oct 31 doi: 10.3389/fendo.2024.1471577. PMID: 39544236Free PMC Article
Zhou Z, Yao Y, Sun Y, Wang X, Huang S, Hou J, Wang L, Wei F
Endocrine 2024 Aug;85(2):649-659. Epub 2024 Mar 6 doi: 10.1007/s12020-024-03732-4. PMID: 38448678
Migała M, Chałubińska-Fendler J, Zielińska M
Rev Diabet Stud 2022 Jun 30;18(2):68-75. doi: 10.1900/RDS.2022.18.68. PMID: 35831937Free PMC Article
Ying L, Ma X, Shen Y, Lu J, Lu W, Zhu W, Wang Y, Bao Y, Zhou J
J Diabetes Res 2020;2020:1243630. Epub 2020 Mar 20 doi: 10.1155/2020/1243630. PMID: 32280712Free PMC Article
Kiniwa N, Okumiya T, Tokuhiro S, Matsumura Y, Matsui H, Koga M
Scand J Clin Lab Invest 2019 Oct;79(6):377-380. Epub 2019 Jun 17 doi: 10.1080/00365513.2019.1627577. PMID: 31204512

Therapy

Kaczor M, Malicki S, Folkert J, Dobosz E, Bryzek D, Chruscicka-Smaga B, Greczan M, Wesół-Kucharska D, Piątosa B, Samborowska E, Madzio J, Książyk J, Ehmke Vel Emczyńska E, Hajdacka M, Potempa J, Młynarski W, Rokicki D, Veillard F
Blood Adv 2024 Jun 11;8(11):2790-2802. doi: 10.1182/bloodadvances.2023012403. PMID: 38531056Free PMC Article
Nakamura S, Tanabe K, Yoshinaga K, Shimura F, Oku T
Br J Nutr 2017 Jul;118(2):81-91. doi: 10.1017/S0007114517001866. PMID: 28820081
Su H, Ma X, Yin J, Wang Y, He X, Bao Y, Zhou J, Jia W
Acta Diabetol 2017 May;54(5):463-470. Epub 2017 Feb 16 doi: 10.1007/s00592-017-0968-z. PMID: 28210869
Kim MK, Kwon HS, Baek KH, Lee JH, Park WC, Sohn HS, Lee KW, Song KH
Diabetes Care 2010 Dec;33(12):2546-8. Epub 2010 Sep 7 doi: 10.2337/dc10-0988. PMID: 20823345Free PMC Article
Yamanouchi T, Akanuma Y, Toyota T, Kuzuya T, Kawai T, Kawazu S, Yoshioka S, Kanazawa Y, Ohta M, Baba S
Diabetes 1991 Jan;40(1):52-7. doi: 10.2337/diab.40.1.52. PMID: 2015974

Prognosis

Xu H, Chen R, Hou X, Li N, Han Y, Ji S
Front Endocrinol (Lausanne) 2024;15:1471577. Epub 2024 Oct 31 doi: 10.3389/fendo.2024.1471577. PMID: 39544236Free PMC Article
Migała M, Chałubińska-Fendler J, Zielińska M
Rev Diabet Stud 2022 Jun 30;18(2):68-75. doi: 10.1900/RDS.2022.18.68. PMID: 35831937Free PMC Article
Ikeda N, Hara H, Hiroi Y, Nakamura M
Atherosclerosis 2016 Oct;253:1-6. Epub 2016 Aug 20 doi: 10.1016/j.atherosclerosis.2016.08.016. PMID: 27569457
Won JC, Park CY, Park HS, Kim JH, Choi ES, Rhee EJ, Lee WY, Oh KW, Kim SW, Park SW
Diabetes Res Clin Pract 2009 Apr;84(1):51-7. Epub 2009 Feb 1 doi: 10.1016/j.diabres.2009.01.002. PMID: 19187997
Sone H, Okuda Y, Yamaoka T, Kawakami Y, Odawara M, Matsushima T, Kawai K, Yamashita K
Diabetes Res Clin Pract 1996 Oct;34(2):83-8. doi: 10.1016/s0168-8227(96)01340-x. PMID: 9031810

Clinical prediction guides

Xu H, Chen R, Hou X, Li N, Han Y, Ji S
Front Endocrinol (Lausanne) 2024;15:1471577. Epub 2024 Oct 31 doi: 10.3389/fendo.2024.1471577. PMID: 39544236Free PMC Article
Migała M, Chałubińska-Fendler J, Zielińska M
Rev Diabet Stud 2022 Jun 30;18(2):68-75. doi: 10.1900/RDS.2022.18.68. PMID: 35831937Free PMC Article
Kiniwa N, Okumiya T, Tokuhiro S, Matsumura Y, Matsui H, Koga M
Scand J Clin Lab Invest 2019 Oct;79(6):377-380. Epub 2019 Jun 17 doi: 10.1080/00365513.2019.1627577. PMID: 31204512
Ikeda N, Hara H, Hiroi Y, Nakamura M
Atherosclerosis 2016 Oct;253:1-6. Epub 2016 Aug 20 doi: 10.1016/j.atherosclerosis.2016.08.016. PMID: 27569457
Yamagishi S, Ohta M
Acta Diabetol 1998 Apr;35(1):65-6. doi: 10.1007/s005920050104. PMID: 9625293

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