U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG1827 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35989, updated on 8-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
CG1827provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033431
Locus tag
Dmel_CG1827
See related
AllianceGenome:FB:FBgn0033431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg1827; Dmel\CG1827
Summary
Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be involved in protein deglycosylation. Predicted to be active in lysosome. Is expressed in adult head; adult heart; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG1827 in Genome Data Viewer
Location:
45F5-45F5; 2-61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9589050..9590443)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5476555..5477948)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene closca Neighboring gene Microtubule-associated protein 60 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human BOULE gene rescues meiotic defects in infertile flies. Xu EY, et al. Hum Mol Genet, 2003 Jan 15. PMID 12499397
  2. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article
  3. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
  4. Endogenously imprinted genes in Drosophila melanogaster. McEachern LA, et al. Mol Genet Genomics, 2014 Aug. PMID 24658702
  5. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons. Xie Q, et al. Elife, 2021 Jan 11. PMID 33427646, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deglycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG1827-PD
NP_610504.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9589050..9590443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136660.3 → NP_610504.4  uncharacterized protein Dmel_CG1827 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610504.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7W5, A1Z7W6, Q6NN89, Q8MR45
    Conserved Domains (1) summary
    cd04513
    Location:58 → 366
    Glycosylasparaginase; Glycosylasparaginase and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR45.1 Q8MR45

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous