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LOC129661503 ReSE screen-validated silencer GRCh37_chr5:122861667-122861854 [ Homo sapiens (human) ]

Gene ID: 129661503, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129661503
Gene description
ReSE screen-validated silencer GRCh37_chr5:122861667-122861854
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129661503 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (123525973..123526160)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (124042205..124042392)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122861667..122861854)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:122758363-122759308 Neighboring gene centrosomal protein 120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16274 Neighboring gene keratin 8 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23005 Neighboring gene high mobility group box 3 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23006 Neighboring gene casein kinase 1 gamma 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:122964549-122965050 Neighboring gene keratin 18 pseudogene 16 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210028-123210778 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123210779-123211528 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123211529-123212279 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123360854-123361427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23008 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123423241-123423991 Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC101927397

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_158539.1 

    Range
    101..288
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    123525973..123526160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    124042205..124042392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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